Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer

Zhang, X.J.; Liu, P.; Fu, Zhu

doi:10.4238/2014.january.24.20

Cited by 12 publications

(13 citation statements)

References 14 publications

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“…Steck et al (2014) did not find significant association between XPG gene polymorphisms and colon cancer risk. Zhang et al (2014) reported that the XPG rs2296147 polymorphism was significantly correlated with prostate cancer susceptibility in a Chinese population. Zhu et al (2012) suggested that XPG rs2296147 C variant genotypes were associated with a significantly lower ESCC risk in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that XPG gene polymorphisms are associated with several kinds of cancers in different ethnicities, such as head and neck cancer, gastric cancer, bladder cancer, colon cancer, prostate cancer (Ma et al, 2012;He et al, 2012;Zhu et al, 2012;Liu et al, 2014;Steck et al, 2014;Zhang et al, 2014). Ma et al (2012) conducted a casecontrol study of 1059 patients with head and neck cancer and 1066 control subjects, and they reported that XPG gene polymorphisms may not affect the risk of head and neck cancer in an American population.…”

Section: Discussionmentioning

confidence: 99%

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Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

Sun

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using polymerase chain reaction-restriction fragment length polymorphism. Using the chisquare test, we did not find any significant differences in the genotype distributions of XPG rs2094258 (χ 2 = 1.48, P = 0.48), rs751402 (χ 2 = 0.65, P = 0.72), and rs17655 (χ 2 = 0.01, P = 0.92) genes between breast cancer patients and control subjects. The genotype distributions of XPG rs2094258, rs751402, and rs17655 did not deviate from the HardyWeinberg equilibrium in control subjects, and the P values were 0.58, 0.97, and 0.26, respectively. Using unconditional logistic regression analysis, we found that XPG rs2094258, rs751402 and rs17655 gene polymorphisms are not associated with the development of breast cancer after adjusting for potential confounding factors. In conclusion, we found that XPG rs2094258, rs751402, and rs17655 do not influence the development of breast cancer in a Chinese population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

Sun

et al. 2016

Genet. Mol. Res.

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“…However, there are vague conclusions about the relationship between XPC rs2228001 A/C polymorphism and PCa susceptibility in different case‐controlled studies. Hence, a systematic analysis based on all eligible studies was conducted to further investigate the correlation between the XPC rs2228001 A/C polymorphism and PCa risk 17‐28 …”

Section: Introductionmentioning

confidence: 99%

Effects of Xeroderma pigmentosum group C polymorphism on the likelihood of prostate cancer

Yan

Wen

et al. 2020

Clinical Laboratory Analysis

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Background Numerous studies have assessed the association between xeroderma pigmentosum complementation group C (XPC) polymorphisms and susceptibility of prostate cancer (PCa); however, the findings remain inconsistent. Methods We performed an updated analysis utilizing data from electronic databases to obtain a more accurate estimation of the relationship between XPC rs2228001 A/C polymorphism and PCa risk. We further used in silico tools to investigate this correlation. Results Totally, 5,305 PCa cases and 6,499 control subjects were evaluated. When all studies pooled together, we detected no positive result (recessive genetic model: OR = 1.14, 95% CI = 0.93‐1.40, Pheterogeneity = 0.001, P = .212); nevertheless, the XPC rs2228001 A/C variant was associated with PCa risk in Asian descendants in the subgroup analysis (OR = 1.21, 95% CI = 1.01‐1.43, Pheterogeneity = 0.008, P = .034). In silico tools showed that more than 20 proteins can participate in the protein crosstalk with XPC. The expression of XPC was down‐regulated in all Gleason scores of prostate cancer. Conclusions The present study indicated that the XPC rs2228001 A/C variant may be associated with elevated PCa risk in Asian patients.

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“…Nevertheless, low penetrance of those genes was demonstrated in prostate cancer [5][6][7]. Therefore, many studies have investigated the possible association between the mutations or polymorphisms in DNA repair genes and the development of prostatic carcinoma [8].…”

Section: Genetic Toxicology Introductionmentioning

confidence: 99%

Polymorphisms of 5’-UTR of rad51 gene in prostate cancer

Zoubi

Al‐Batayneh

Trad

et al. 2018

Ecological genetics

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Background. Notwithstanding that prostate cancer is largely studied all over the world for many decades, its etiology is not known and there is an intensive work to elucidate the cause and molecular markers for the development of this male cancer. Polymorphisms in DNA repairing genes may affect the DNA repairing capacity that in turn contributes to cancer development. This study aims to explore the polymorphisms of homologous recombination (HR) RAD51 gene (rs1801320 and rs1801321) as a possible risk factor for developing prostate cancer. Sequencing of 5'-UTR of RAD51 gene (rs1801320 and rs1801321) was studied in 80 DNA samples of prostate cancer and 50 DNA samples from a control group. Our results revealed a significant correlation between rs1801320 G>C polymorphism and the presence of prostate cancer in the Jordanian population (p = 0.041, X2 = 6.377). On the other hand, the rs1801321 G>T polymorphism was not associated with the presence of prostate cancer in the study population (p = 0.27, X2 = 2.6). In conclusion, our results shed a light on the possible role of RAD51 gene polymorphisms in the development of prostate cancer; however, a larger representative study is needed to elucidate a possible role of RAD51 gene polymorphisms in development and prognosis of prostate cancer.

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Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer

Cited by 12 publications

References 14 publications

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

Effects of Xeroderma pigmentosum group C polymorphism on the likelihood of prostate cancer

Polymorphisms of 5’-UTR of rad51 gene in prostate cancer

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