Polymorphisms of 5’-UTR of rad51 gene in prostate cancer

Abstract

Background. Notwithstanding that prostate cancer is largely studied all over the world for many decades, its etiology is not known and there is an intensive work to elucidate the cause and molecular markers for the development of this male cancer. Polymorphisms in DNA repairing genes may affect the DNA repairing capacity that in turn contributes to cancer development. This study aims to explore the polymorphisms of homologous recombination (HR) RAD51 gene (rs1801320 and rs1801321) as a possible risk factor for developing prostate cancer. Sequencing of 5'-UTR of RAD51 gene (rs1801320 and rs1801321) was studied in 80 DNA samples of prostate cancer and 50 DNA samples from a control group. Our results revealed a significant correlation between rs1801320 G>C polymorphism and the presence of prostate cancer in the Jordanian population (p = 0.041, X2 = 6.377). On the other hand, the rs1801321 G>T polymorphism was not associated with the presence of prostate cancer in the study population (p = 0.27, X2 = 2.6). In conclusion, our results shed a light on the possible role of RAD51 gene polymorphisms in the development of prostate cancer; however, a larger representative study is needed to elucidate a possible role of RAD51 gene polymorphisms in development and prognosis of prostate cancer.

Association of XRCC1 Arg399Gln and RAD51 135 G>C Polymorphisms and Epidemiologic Risk Factors with Colorectal Cancer Among Selected Filipinos

“…Besides being associated with CRC, RAD51 135G>C has also been linked with breast cancer development among Saudi females 28 and prostate cancer among Jordanians. 21 In the study of Ragudo et al (2020) 36 , the more common RAD51 G/C genotype was not associated with breast cancer development among Filipinos, while the less common recessive C/C genotype was observed to potentially increase the risk. XRCC1 Arg399Gln has been associated with breast cancer among Serbian women 22 and lung cancer among Chinese.…”

Comparative Studies on the Corrosion Inhibition of Three Different Organic Heterocyclic Compounds as Corrosion Inhibitors for Mild Steel in Hydrochloric Acid

“…They inhibit corrosion by adsorbing at metal/electrolyte interface. [28] The diameter of capacitive loop increased with increase in inhibitor concentration, suggesting the improved inhibition efficiency of these molecules TZACI, TZCDI and TZCOI at higher inhibitor concentrations. Table 4 showed the electrochemical impedance spectroscopy (EIS) parameters in the absence and the presence of the three corrosion inhibitors of mild steel in 1.0 M HCl.…”

Benefícios da aplicação do método de avaliação de plataformas digitais Delone & McLean para o e-learning: uma revisão sistemática

“…A expansão das redes de internet possibilita diversos benefícios, como a democratização do acesso à informação (AL ZOUBI;ALZOUBI,2019). O conteúdo presente no mundo virtual rompe as fronteiras geográficas e concede aos usuários informações, entretenimento e conhecimento de acordo com interesses específicos (MONDINI; RODRIGUES, 2018).A classe trabalhadora, que apresenta históricas restrições de horários para realização de cursos nas instituições de ensino além de dificuldades logísticas para acesso à sala de aula física, tornou-se um dos principais usuários das plataformas de ensino (MOHAMOODI et al, 2017).…”