DNA methylation contributes to natural human variation

Heyn, Holger; Morán, Sebastian; Hernando-Herraez, Irene; Sayols, Sergi; Gómez, Antonio; Sandoval, Juan; Monk, Dave; Hata, Kenichiro; Marquès‐Bonet, Tomàs; Wang, Liewei; Esteller, Manel

doi:10.1101/gr.154187.112

Cited by 353 publications

(353 citation statements)

References 57 publications

Supporting

Mentioning

338

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that the stable epigenetic marks represent those determined by genetics, while the variable marks are more likely to be influenced by the environment 64 . A comparison of methylation profiles between populations of different ethnic backgrounds showed that about two-thirds of population-specific CpGs are associated with genetic background 104 , while one-third might be influenced by other factors.…”

Section: Stability and Inter-individual Variation In Dna Methylationmentioning

confidence: 99%

Epigenetics and human obesity

Molloy

Varinli³

et al. 2014

Int J Obes

293

214

View full text Add to dashboard Cite

show abstract

Section: Stability and Inter-individual Variation In Dna Methylationmentioning

confidence: 99%

Epigenetics and human obesity

Molloy

Varinli³

et al. 2014

Int J Obes

293

214

View full text Add to dashboard Cite

show abstract

“…Studies of methylation differences using Illumina InfiniumHumanMethylation450 BeadChip array data from 133 lymphoblastoid cell lines from European and African HapMap samples found that 13% of analyzed CpGs showed significant methylation differences between the populations, >50% of which were in methQTLs with local SNPs (Moen et al 2013). CpGs showing differential methylation levels across ethnicities are more likely to be driven by genotype than other CpGs (Heyn et al 2013). Nevertheless, these studies also found that some methQTLs are specific to one population with no correlation between genotype and methylation in other populations, suggesting possible gene 3 environment interactions.…”

mentioning

confidence: 99%

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

et al. 2014

View full text Add to dashboard Cite

Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as a mechanism for the enduring effects of the prenatal environment. Accordingly, neonate methylomes contain molecular memory of the individual in utero experience. However, interindividual variation in methylation can also be a consequence of DNA sequence polymorphisms that result in methylation quantitative trait loci (methQTLs) and, potentially, the interaction between fixed genetic variation and environmental influences. We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctuate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. MethQTLs were readily detected in neonatal methylomes, and genotype alone best explained~25% of the VMRs. We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression, maternal BMI, infant birth weight, gestational age, and birth order. Our study sheds new light on the complex relationship between biological inheritance as represented by genotype and individual prenatal experience and suggests the importance of considering both fixed genetic variation and environmental factors in interpreting epigenetic variation.

show abstract

“…DNA methylation particularly 5mC (5-methylcytosine) methylation at the CpG sites, the major epigenetic and chemical change in the DNA [41] which without altering the DNA sequence leads to phenotypic variation among the various tissues, monozygotic twins or among humans has provided a new vista to distinguish cell types or tissues [42,43], monozygotic twins [44][45][46], age of humans [47][48][49], human bio-geographic types [44,50] or even can be used to predict certain criminal behaviors [51][52][53]. This 15-dalton mark of methylation in the bases of DNA sequence can help to solve an array of critical cases in forensic biology which when stands gloomy with current polymorphic STR technology.…”

Section: Dna Methylationmentioning

confidence: 99%

The Future of Forensic Biology

Rana¹

2018

J. Biomed

View full text Add to dashboard Cite

The recent technological and scientific development in the field of forensic biology is certainly stamping a huge impact in capturing and convicting the criminals without any doubt. This review enlists forthcoming emerging technologies in forensic biology which would become inevitable and routine tasks in laboratories for solving extremely challenging and critical cases. These include touch DNA profiling, forensic phenotyping, 3D facial reconstruction and morphometrics, microbial forensics, virtual autopsy, DNA methylation and next-generation sequencing methods which would prove boon sooner or later for the crime investigators in finding missing persons, nabbing murderers and sexual assaulters and solving an array of cold cases.

show abstract

DNA methylation contributes to natural human variation

Cited by 353 publications

References 57 publications

Epigenetics and human obesity

Epigenetics and human obesity

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

The Future of Forensic Biology

Contact Info

Product

Resources

About