DNA interaction with dipolar ruthenium(II) ammine complexes containing 4,4′-bipyridinium as photochemotherapeutic agents

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

“…When photoactivated, surface-grafted ruthenium complexes on mesoporous silica nanoparticles undergo photoexpulsion and subsequent release as cytotoxic entities toward cancer cells [120]. Nowadays, numerous accounts on photoactivatable Ru(II) complexes that exhibit different types of biologically relevant activities have been published [121,122,123,124,125]. Of real consequence for therapeutic purposes, catalytic reactions induced in cells by certain metallodrugs pertaining to the class of redox modulators or photosensitizers may ensure low-dose therapy protocols [126].…”

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

“…Metal complexes of ruthenium have been for more than twenty years in the focus of many researches in chemistry [1][2][3][4] as well as in medicine [5,6]. Their properties can be altered by the choice of ligands, which means that complexes potentially have multiple applications.…”

“…Ruthenium complexes show an antimicrobial activity [5,7] but their most interesting activity is on tumor cells [8][9][10] with developed resistance to the usual medicinal treatment, including cisplatin. The advantage of ruthenium complexes is their relatively low toxicity [6,11], lower than cisplatin, which can partly be explained by its reduced reactivity to DNA in intact cells. Many biological properties have been attributed to ruthenium complexes including antioxidant activity [12,13] and cytotoxicity [3,9,10].…”