DNA-graphene interactions during translocation through nanogaps

Patel, Hiral N.; Carroll, Ian; Lopez, Rodolfo; Sankararaman, Sandeep; Etienne, C. Petit; Kodigala, Subba Ramaiah; Paul, Mark; Postma, Henk W. Ch.

doi:10.1371/journal.pone.0171505

Cited by 12 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, graphene nanopores have been widely explored both theoretically and experimentally for sequencing DNA. Recently, Patel and his co-workers have also experimentally realized the graphene nanogap device for single-molecule detection . To this end, we investigate the graphene electrodes as a field-effect transistor-based nanogap device for the sequencing of labeled DNA nucleotides.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Patel and his co-workers have also experimentally realized the graphene nanogap device for singlemolecule detection. 24 To this end, we investigate the graphene electrodes as a field-effect transistor-based nanogap device for the sequencing of labeled DNA nucleotides. Graphene has several major advantages like its single-atom thickness, which is more promising to achieve single-nucleotide resolution, excellent conductivity, and stability up to high temperature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amplifying Quantum Tunneling Current Sensitivity through Labeling Nucleotides Using Graphene Nanogap Electrodes

Mittal

Jena

Pathak

2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Recent advances in cost-effective, ultra-rapid, and efficient DNA sequencing are in the saddle of the advancement of the personalization of medicines for understanding and early-stage detection of several killer diseases. Paying attention to a timely need for the development of solid-state nanodevices for rapid and controlled identification of DNA nucleotides, in this report, we theoretically explored the potential of labeling techniques in the sequencing of DNA nucleotides through solid-state graphene nanogap electrodes using the quantum tunneling current approach. Our study boasts the idea that labeling of DNA nucleotides can solve major hurdles of DNA sequencing, such as improving the signal-to-noise ratio, slowing down translocation velocity, and controlling orientational variations. Employing the first-principle density functional theory study, we identify unique interaction energy values for each labeled nucleotide having remarkable differences in the range of 0.10–0.74 eV. The zero-bias transmission spectra of the proposed setup suggest that the detection of the nucleotides is possible by applying very low gate voltages. Moreover, the labeling of nucleotides amplifies the conductance sensitivity considerably. I–V characteristics suggest that electrical recognition of each labeled nucleotide can be carried out at both lower (0.3 V) and higher (0.8 V) bias voltages with single-molecule resolution, although the maximum current sensitivity is observed at a higher bias voltage. The proposed sequencing device possesses high sensitivity and selectivity characteristics that are crucial for experimental purposes. We find that our results are rich compared to unlabeled nucleotides-based graphene nanopore/nanogap devices. Hence, the study will certainly motivate the experimentalists toward the application of a labeled DNA nucleotide system for ultra-rapid DNA sequencing by using the tunneling current approach.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amplifying Quantum Tunneling Current Sensitivity through Labeling Nucleotides Using Graphene Nanogap Electrodes

Mittal

Jena

Pathak

2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…The reported resolution of GFETs, often conjugated with metal nanoparticles (e.g., Au) can be lowered down to the pM range [40,41]. Despite the interesting sensing applications, continuous investigations are still required to improve the reduced DNA translocation dynamics and the low-frequency noise levels [32,42,43]. Other applications are concerned with protein detection, living cell and bacteria monitoring [33,44].…”

Section: Fin Field-effect Transistor (Finfet) Tunnel Fetmentioning

confidence: 99%

Emerging Designs of Electronic Devices in Biomedicine

et al. 2020

View full text Add to dashboard Cite

A long-standing goal of nanoelectronics is the development of integrated systems to be used in medicine as sensor, therapeutic, or theranostic devices. In this review, we examine the phenomena of transport and the interaction between electro-active charges and the material at the nanoscale. We then demonstrate how these mechanisms can be exploited to design and fabricate devices for applications in biomedicine and bioengineering. Specifically, we present and discuss electrochemical devices based on the interaction between ions and conductive polymers, such as organic electrochemical transistors (OFETs), electrolyte gated field-effect transistors (FETs), fin field-effect transistor (FinFETs), tunnelling field-effect transistors (TFETs), electrochemical lab-on-chips (LOCs). For these systems, we comment on their use in medicine.

show abstract

“…The experiment realization of the DNA sequencing based on tunneling current through graphene nanogaps is challenging. So far, no sequencing test has been conducted though, Postma’s group [ 83 ] experimentally studies the translocation of DNA molecules through graphene nanogap, which could open up new advancement for the construction of DNA sequencing devices. In view of the theoretical studies and successes in fabricating tunneling electrodes, interesting experimental data on this area can be expected in near future.…”

Section: Gnps Gnrs and Graphene Nanogaps Based Dna Sequencingmentioning

confidence: 99%

Graphene and Graphene-Based Nanomaterials for DNA Detection: A Review

Wang

et al. 2018

Molecules

View full text Add to dashboard Cite

DNA detection with high sensitivity and specificity has tremendous potential as molecular diagnostic agents. Graphene and graphene-based nanomaterials, such as graphene nanopore, graphene nanoribbon, graphene oxide, and reduced graphene oxide, graphene-nanoparticle composites, were demonstrated to have unique properties, which have attracted increasing interest towards the application of DNA detection with improved performance. This article comprehensively reviews the most recent trends in DNA detection based on graphene and graphene-related nanomaterials. Based on the current understanding, this review attempts to identify the future directions in which the field is likely to thrive, and stimulate more significant research in this subject.

show abstract

DNA-graphene interactions during translocation through nanogaps

Cited by 12 publications

References 34 publications

Amplifying Quantum Tunneling Current Sensitivity through Labeling Nucleotides Using Graphene Nanogap Electrodes

Amplifying Quantum Tunneling Current Sensitivity through Labeling Nucleotides Using Graphene Nanogap Electrodes

Emerging Designs of Electronic Devices in Biomedicine

Graphene and Graphene-Based Nanomaterials for DNA Detection: A Review

Contact Info

Product

Resources

About