Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

Sun, Lixin; Wu, Jie; Luo, Min; Wang, Xiaoli; Man, Pan; Gou, Zhaopin; Sun, Dequn

doi:10.3390/molecules16119739

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…Finally, ortho -carboranyl hydrophilic ether compounds were generated from ( Z,Z ′)-1,1′-(4- ortho -Caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) and side hydrophilic alkyl or aromatic halide reagents, followed by a treatment with potassium carbonate to result in the target compounds 4 – 8 (Scheme 2 ) [ 22 , 23 ]. A treatment of ortho -carborane (C 2 H 2 B 10 H 10 ) with aromatic halide as a base in tetrahydrofuran produced the target compounds 1 – 3 in moderate yields (1 93, 2 97, and 3 92%).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Jin

Xiao

Liu

2018

Chemistry Central Journal

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(Z,Z’)-1,1′-(4-ortho-Caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) intermediate 3 was synthesized by a three-step reaction with a final treatment with base to give a new series of ortho-carboranyl biphenyloxime derivatives (4–8). Compounds 7 and 8 showed high solubility and the in vitro study results revealed high levels of accumulation in HeLa cells with higher cytotoxicity and boron uptake compared to l-boronphenylalanine. Electronic supplementary materialThe online version of this article (10.1186/s13065-018-0444-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Jin

Xiao

Liu

2018

Chemistry Central Journal

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“…26, No. 16 (2014), 5291-5294 research workers identified the antimicrobial potential of benzophenone nucleus and much research has been focused on the synthesis of its various derivatives for antibacterial and antifungal activities 20,21 .…”

Section: Synthesis and Antimicrobial Evaluation Of 2-aminobenzophenonmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Li¹,

Sahore²,

Li³

et al. 2014

Asian J. Chem.

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A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, 1 H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gramnegative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.

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“…[21] Likewise, 1,2,3-triazole serves as an attractive heterocyclic group to connect two pharmacophores and biologically active fragments into one molecule to get progressive multifunctional compounds. [22][23][24][25][26][27] Moreover, the binding ability of 1,2,3-triazole framework with molecular targets due to their rigidity, high dipole moment, stability and capability to form hydrogen bonding under in vivo conditions has resulted in highly potent bioactive agents. [28,29] In view of the aforementioned biological significance, we decided to fuse coumarin, β-lactam, and 1,2,3-triazole pharmacophoric units into a single architecture using the concept of molecular hybridization.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin‐Tagged β‐Lactam Triazole Hybrid

Dhawan

Awolade

Kisten

et al. 2020

Chemistry & Biodiversity

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A series of coumarin-tagged β-lactam triazole hybrids (10a -10o) were synthesized and tested for their cytotoxic activity against MDA-MB-231 (triple negative breast cancer), MCF-7 (estrogen receptor positive breast cancer (ER +)) and A549 (human lung carcinoma) cancer cell lines including one normal cell line, HEK-293 (human embryonic kidney). Two compounds 10b and 10d exhibited substantial cytotoxic effect against MCF-7 cancer cell lines with IC 50 values of 53.55 and 58.62 μM, respectively. More importantly, compounds 10b and 10d were non-cytotoxic against HEK-293 cell lines. Structure-activity relationship (SAR) studies suggested that the nitro and chloro group at the C-3 position of phenyl ring are favorable for anticancer activity, particularly against MCF-7 cell lines. Furthermore, antimicrobial evaluation of these compounds revealed modest inhibition of examined pathogenic strains with compounds 10c and 10i being the most promising antimicrobial agents against Pseudomonas aeruginosa and Candida albicans, respectively.

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Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

Cited by 15 publications

References 16 publications

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin‐Tagged β‐Lactam Triazole Hybrid

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