Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Abstract

(Z,Z’)-1,1′-(4-ortho-Caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) intermediate 3 was synthesized by a three-step reaction with a final treatment with base to give a new series of ortho-carboranyl biphenyloxime derivatives (4–8). Compounds 7 and 8 showed high solubility and the in vitro study results revealed high levels of accumulation in HeLa cells with higher cytotoxicity and boron uptake compared to l-boronphenylalanine. Electronic supplementary materialThe online version of this article (10.1186/s13065-018-0444-z) contains supplementary material, which is available to authorized users.

Synthesis and Characterization of Boron Carbide Nanoparticles as Potential Boron-Rich Therapeutic Carriers

“…As expected, BPA showed no cytotoxic activity in the range of the tested concentrations, similarly to the other report [37]. After 72 h of cell exposure to the boron carbides, the different cell sensitivity was observed depending on the cell types.…”

“…This B 4 C property can also facilitate its wide spreading in the biological environment and increase the effective delivery into the tumor site. As expected, BPA showed no cytotoxic activity in the range of the tested concentrations, similarly to the other report [37]. After 72 h of cell exposure to the boron carbides, the different cell sensitivity was observed depending on the cell types.…”