Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Abstract

A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, 1 H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gramnegative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.

Antibacterial and antileishmanial activity of 1,4-dihydropyridine derivatives

“…28 A 2-aminobenzophenone derived from compound 22 has been reported to be weakly active against S. aureus and E. coli. 26 Nevertheless, to the best of our knowledge, the antibacterial activity of 1,4-DHPs against cariogenic bacteria has not been reported yet.…”

“…In addition, several compounds of this class are active against bacteria [14][15][16][17] and parasites. [18][19][20] As part of our interest in exploring the antimicrobial and antiparasitic activities of natural [21][22][23] and synthetic 8,24,25 compounds, and on the basis of the previous reports on the antibacterial 17,[26][27][28] and antileishmanial [18][19][20]29 activities of 1,4-DHP derivatives (1,, in this study we have evaluated the antibacterial action of 23 synthetic 1,4-DHPs against a representative panel of cariogenic bacteria and their antileishmanial activity against L. amazonensis promastigotes.…”

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

“…In addition to this benzophenone also has antimicrobial potential, so the synthesized derivatives given in Table were tested for antibacterial activity against E. coli and S. aureus at various concentrations. However none of the derivative exhibited any significant activity in comparison to the standard Amoxicillin …”

ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity

“…In the field of catalysis, one optimization factor is the development of the use of nanocatalysts . The high yields and good selectivity of some organic reactions occur with nanocatalysts compared with the normal‐sized forms . This is due to enhanced catalytic activity of nanocatalysts, resulting from increased surface area .…”

“…[17] The high yields and good selectivity of some organic reactions occur with nanocatalysts compared with the normalsized forms. [18][19][20][21][22][23][24][25][26][27][28] This is due to enhanced catalytic activity of nanocatalysts, resulting from increased surface area. [29,30] In recent years, metal oxides, because of their acid-base and redox properties, are the chief kinds of heterogeneous catalysts.…”