Divergent risk of multiple sclerosis in two anabaptist communities in America

Lauer, Klaus

doi:10.1016/j.mehy.2006.03.044

“…The occurrence of MS in some religious groups gave also support to the present hypothesis [64]. These Anabaptist groups have their background in the haunting German history of the late 16th century.…”

Section: Further Epidemiological Findings In Support Of the Hypothesissupporting

confidence: 81%

Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits

Lauer¹

2014

IJMS

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A hypothesis, based primarily on the occurrence of multiple sclerosis (MS) in the Faroe Islands and supported by numerous analytical epidemiological studies, is described. It proposes that MS is caused by the interaction of a virus disease with intestinal pathology, e.g., infectious mononucleosis, and application of smoked and nitrate/nitrite-cured meat products in the diet during circumscribed time intervals. The biological mechanisms might involve a break of tolerance by an alteration of self within the central nervous system, by nitrophenylated compounds conjugated to animal tissue, in particular to proteins occurring in the central nervous system. Further research is needed.

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“…After selecting studies according to the inclusion criteria, 47 articles considered for further review. Six of these 47 articles could not provide outcome information ( Brosseau et al, 1993 ; Guimond et al, 2014 ; Lauer, 2006 ; Nortvedt, Riise & Maeland, 2005 ; Senecal-Quevillon, Duquette & Richer, 1986 ; Turner et al, 2007 ). We could not obtain the full article for 5 of the 47 articles ( Dobosz, Tyrpien & Pierzchala, 2012 ; Frutos Alegria et al, 2002a ; Frutos Alegria et al, 2002b ; Ragonese et al, 2007 ; Rodriguez Regal et al, 2009 ).…”

Section: Resultsmentioning

confidence: 99%

The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies

Zhang

¹

,

Wang

²

,

Li

³

et al. 2016

PeerJ

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Background. Multiple sclerosis (MS) has become a disease that represents a tremendous burden on patients, families, and societies. The exact etiology of MS is still unclear, but it is believed that a combination of genetic and environmental factors contribute to this disease. Although some meta-analyses on the association between smoking and MS have been previously published, a number of new studies with larger population data have published since then. Consequently, these additional critical articles need to be taken into consideration.Method. We reviewed articles by searching in PubMed and EMBASE. Both conservative and non-conservative models were used to investigate the association between smoking and the susceptibility to MS. We also explored the effect of smoking on the susceptibility to MS in strata of different genders and smoking habits. The association between passive smoking and MS was also explored.Results.The results of this study suggest that smoking is a risk factor for MS (conservative model: odds ratio (OR) 1.55, 95% CI [1.48–1.62], p < 0.001; non-conservative model: 1.57, 95% CI [1.50–1.64], p < 0.001). Smoking appears to increase the risk of MS more in men than in women and in current smokers more than in past smokers. People who exposed to passive smoking have higher risk of MS than those unexposed.Conclusion.This study demonstrated that exposure to smoking is an important risk factor for MS. People will benefit from smoking cessation, and policymakers should pay attention to the association between smoking and MS.

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“…After selecting studies according to the inclusion criteria, articles considered for further review. Six of these 47 articles could not provide outcome information (Brosseau et al 1993;Guimond et al 2014;Lauer 2006;Nortvedt et al 2005;Senecal-Quevillon et al 1986;Turner et al 2007). We could not obtain the full article for 5 of the 47 articles (Dobosz et al 2012;Frutos-Alegria et al 2002;Ragonese P et al 2007;Rodriguez Regal et al 2009).…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Peer Review #1 of "The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies (v0.1)"

Dehnavi¹

2016

0

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Background. Multiple sclerosis (MS) has become a disease that represents a tremendous burden on patients, families, and societies. The exact etiology of MS is still unclear, but it is believed that a combination of genetic and environmental factors contribute to this disease. Although some meta-analyses on the association between smoking and MS have been previously published, a number of new studies with larger population data have published since then. Consequently, these additional critical articles need to be taken into consideration. Method. We reviewed articles by searching in PubMed and EMBASE. Both conservative and non-conservative models were used to investigate the association between smoking and the susceptibility to MS. We also explored the effect of smoking on the susceptibility to MS in strata of different genders and smoking habits. The association between passive smoking and MS was also explored. Results. The results of this study suggest that smoking is a risk factor for MS (conservative model: odds ratio (OR) 1.55,

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Divergent risk of multiple sclerosis in two anabaptist communities in America

Cited by 7 publications

References 47 publications

Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits

Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits

The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies

Peer Review #1 of "The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies (v0.1)"

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