Diuretic effects of selected Thai indigenous medicinal plants in rats

Sripanidkulchai, Bungorn; Wongpanich, Varima; Laupattarakasem, Pisamai; Suwansaksri, Jamsai; Jirakulsomchok, Dusit

doi:10.1016/s0378-8741(01)00173-8

Cited by 75 publications

(34 citation statements)

References 1 publication

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“…Besides agricultural utilities such as being a fruit with nutritional value, some folk medicinal uses have been found. In Thailand, A. comosus was used as an indigenous medicinal plant (4,5) for the treatment of dysuria. In China, A. comosus cortexes served as alexipharmic, antitussive, and antidiarrheal agents; and A. comosus leaves were usually used as an antidyspepsia or antidiarrheal agent in Chinese Traditional Medicine (6).…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Xie

Wang

et al. 2007

J Pharmacol Sci

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Abstract. In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. leaves (AC) in mice and then determined its activities in related enzymes. The results showed that AC (0.40 g / kg) significantly inhibited the increase in serum triglycerides by 40% in fructose-fed mice. In mice induced by alloxan and high-fat diets, serum total cholesterol remained at a high level (180 -220 mg / dl) within 7 days of removing high-fat diets but reached normal level (120 -140 mg / dl) after AC (0.40 g / kg per day) treatment. Also, AC (0.40 and 0.80 g / kg) significantly inhibited serum lipids from the increase in Triton WR-1339-induced hyperlipidemic mice. AC (0.01 -100 µg / ml) selectively activated lipoprotein lipase (LPL) activity by 200% -400% and significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity by 20% -49% in vitro. Furthermore, 2 months of fenofibrate (0.20 g / kg) administration particularly increased mice liver weights (0.0760 ± 0.0110 g / g) while AC (0.40 g / kg) had no effect (0.0403 ± 0.0047). Taken together, these results suggest that AC will be a new potential natural product for the treatment of hyperlipidemia that exerts its actions through mechanisms of inhibiting HMGCoA reductase and activating LPL activities. Its action mechanisms differentiate from those with fibrates but may be partly similar to those with statins. It is hopeful that AC may serve as the adjuvant for fibrates.

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Section: Introductionmentioning

confidence: 99%

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Xie

Wang

et al. 2007

J Pharmacol Sci

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“…Adult male SpragueDawley rats were given an oral dose of 10 mg/kg of Carica papaya root extracts. The demonstrated increased urine output (p < 0.01) was similar to receiving hydrochlorothiazide 10 mg/kg [25].…”

Section: Diuretic Activitymentioning

confidence: 69%

Invitro Study of Thrombolytic Activity by Using Aqueous Preparation of Different Parts of Carica Papaya Plant Extract

Kalaiyarasi¹,

sultana.D²

2014

IOSRJPBS

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“…It is well known that hydrochlorothiazide acts on the distal convoluted tubule and inhibits the sodium-chloride symporter leading to the retention of water in the urine (Sripanidkulchai et al, 2001) as water normally follows penetrating solutes. In our experiments, both HCTZ and RIEA fraction promoted water excretion from experimental rats.…”

Section: Discussionmentioning

confidence: 99%

Diuretic Activity of Methanol Extracts of Rubus idaeus L.

Zhang¹,

Zhang²,

Yang³

et al. 2011

IJB

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The purpose of this article is to evaluate the diuretic potential of Rubus idaeus L. fruits. By measuring the urine volume of experimental animals, we find that methanol extract of Rubus idaeus L. fruits significantly increased the urine volume of experimental animals suggesting its diuretic effect. This is the first formal report on the diuretic activity of Rubus idaeus L. fruits. Moreover, four fractions isolated from the methanol extract were further studied and the results showed that ethyl acetate fraction (RIEA) has a direct relationship with the diuretic activity of Rubus idaeus L. fruits. The urinary electrolyte patterns of experimental animals were also analyzed, we find that Rubus idaeus L. fruits have an effect on the conservation of potassium, which is an interesting property in a phyto-diuretic.www.ccsenet.org/ijb

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Diuretic effects of selected Thai indigenous medicinal plants in rats

Cited by 75 publications

References 1 publication

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Invitro Study of Thrombolytic Activity by Using Aqueous Preparation of Different Parts of Carica Papaya Plant Extract

Diuretic Activity of Methanol Extracts of Rubus idaeus L.

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