Diuretic, anti-inflammatory, and analgesic activities of the ethanol extract from Cynoglossum lanceolatum

Yu, Chenghao; Tang, Weizhong; Peng, Cheng; Sun, Tao; Liu, Bin; Li, Min; Xie, Xiao-Fang; Zhang, Hong

doi:10.1016/j.jep.2011.10.031

Cited by 22 publications

(15 citation statements)

References 15 publications

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“…The second animal model was egg-white-induced nonspecific inflammation, which is fit for evaluation of anti-inflammatory agents and is used frequently to assess the antiedematous effect of natural products [25]. Injection of egg white caused the foot edema, redness, and the increase in skin temperature of the affected paw.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of Orally Administrated Denatured Naja Naja Atra Venom on Murine Rheumatoid Arthritis Models

Zhu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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To investigate the antinociceptive and anti-inflammatory activities of the denatured Naja Naja atra venom (NNAV) in rheumatoid arthritis-associated models, the denatured NNAV (heat treated; 30, 90, 270 μg/kg), the native NNAV (untreated with heat; 90 μg/kg), and Tripterygium wilfordii polyglycoside (TWP, 15 mg/kg) were administrated orally either prophylactically or therapeutically. We measured time of licking the affected paw in formaldehyde-induced inflammatory model, paw volume in egg-white-induced inflammation, and granuloma weight in formalin-soaked filter paper-induced granuloma. For adjuvant-induced arthritis (AIA) rats, paw edema, mechanical withdrawal threshold, serum levels of TNF-α and IL-10, and histopathological changes of the affected paw were assessed. We found that the denatured NNAV (90, 270 μg/kg) significantly reduced time of licking paw, paw volume, and granuloma weight in above inflammatory models and also attenuated paw edema, mechanical hyperalgesia, and histopathology changes in AIA rats. Additionally, the increase in serum TNF-α and the decrease in serum IL-10 in AIA rats were reversed by the denatured NNAV. Although the native NNAV and TWP rendered the similar pharmacological actions on the above four models with less potency than that of the denatured NNAV, these findings demonstrate that oral administration of the denatured NNAV produces antinociceptive and anti-inflammatory activities on rheumatoid arthritis.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of Orally Administrated Denatured Naja Naja Atra Venom on Murine Rheumatoid Arthritis Models

Zhu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Nonetheless, the control groups were given distilled water of the same volume. On day 15, the mice were killed and the pellets and surrounding granulation tissues were dried at 58°C for 24 h. Granuloma weight equal to the weight of the dry subtracted from cotton weight and the weight of granuloma was determined (Yu et al, 2012).…”

Section: Cotton Pellet Granuloma In Micementioning

confidence: 99%

Anti-bacterial and anti-inflammatory effects of Tanshinone breast filler in mice

Ye¹,

Yun²,

Fuwei³

et al. 2015

Afr. J. Pharm. Pharmacol.

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The purpose of this study was to investigate the antibacterial and anti-inflammatory activities of Tanshinone breast filler (TBF) against cow mastitis. TBF on bacterial activity in vitro by the method of Oxford cup and the mice were treated by TBF before given the mixed bacterial by intraperitoneal injection in vivo. The effect of TBF against acute inflammation was studied by xylene-induced ear edema and egg white-induced paw edema in mice. The activity of TBF against chronic inflammation was assessed by the cotton pellet. TBF significantly inhibited staphylococcus aureus, staphylococcus epidermidis, streptococcus dysgalactiae and escherichia coli in vitro and vivo. TBF showed significant activity against acute inflammation on ear edema induced by xylene and paw swelling induced by egg white in mice. In chronic inflammation, TBF inhibited significant effects on cotton-induced mice granuloma. In conclusion, TBF had obvious effect against acute inflammation and chronic inflammation in mice and suppressed pathogenic bacteria in vitro and vivo.

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“…A variety of drugs are commonly found like nonsteroidal anti-inflammatory drugs (NSAIDs), opioids etc. for removal of pain but these are not completely free from side effects (Su et al, 2012;Yu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

2018

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The hexane (HE), dichloromethane (DCME), ethyl acetate (EAE) and methanol (ME) extracts of seed and stem of Anethum sowa were subjected to screenings for analgesic, anti-diarrheal and anti-depressant activities. The peripheral and central analgesic actions were determined by using formalin-induced writhing test and tail immersion method. The DCME extract of stem, at a dose of 200 mg/kg body weight, significantly reduced the number of writhing movements whereas the methanol extract of seed at the same dose exhibited remarkable analgesic activity in tail immersion method. In castor oil induced anti-diarrheal assay, the ethyl acetate extract of stem, at 400 mg/kg body weight, exhibited significant anti-diarrheal effect. In addition, significant anti-depressant activity was observed at a dose of 400 mg/kg body weight as compared to the standard drug in case of HE extract of stem.

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Diuretic, anti-inflammatory, and analgesic activities of the ethanol extract from Cynoglossum lanceolatum

Cited by 22 publications

References 15 publications

Antinociceptive and Anti-Inflammatory Effects of Orally Administrated Denatured Naja Naja Atra Venom on Murine Rheumatoid Arthritis Models

Antinociceptive and Anti-Inflammatory Effects of Orally Administrated Denatured Naja Naja Atra Venom on Murine Rheumatoid Arthritis Models

Anti-bacterial and anti-inflammatory effects of Tanshinone breast filler in mice

Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

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