Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

Mansur, Muhammad; Siddiqi, M Mahboob Ali; Saha, Koushik

doi:10.3329/bpj.v21i1.37899

Cited by 3 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoglycemic activity was evaluated by oral glucose tolerance test (OGTT). 20 In this assay, the experimental animals were also divided into negative control, standard and test groups containing three mice in each group. At zero-hour, test samples (HFLS, CFLS, AFLS at 500 mg/kg body weight), control and standard glibenclamide (10 mg/kg body weight) were administered orally.…”

Section: Peripheral Analgesic Activitymentioning

confidence: 99%

In vitro and in vivo Evaluation of Pharmacological Potential of Lasia spinosa Linn.

Chowdhury

Ibrahim

Shahadat

et al. 2021

Dhaka Univ. J. Pharm. Sci

View full text Add to dashboard Cite

Lasia spinosa Linn. (Family: Araceae) is an important medicinal plant, which is traditionally used for treatment of different human ailments. The present study was undertaken to evaluate the in vitro thrombolytic, antiinflammatory and in vivo analgesic and hypoglycemic potentials of n-hexane, chloroform and aqueous soluble fractions of methanol extract of L. spinosa whole plant. Additionally, phytochemical screening was carried out by qualitative tests, which confirmed the presence of alkaloids, glycosides, steroids, tannins, saponin in this plant. During in vitro thrombolytic assay, the aqueous fraction at a dose of 500 μg/100 μl showed the maximum 33.15% lysis of the blood clot, as compared to the standard streptokinase (80.10%). The in vitro anti-inflammatory test was performed by inhibition of egg albumin denaturation assay and RBC membrane stabilization method. The chloroform fraction exhibited maximum anti-inflammatory potential by inhibiting 51.53% denaturation of albumin and by inhibiting 54.8% hemolysis of RBC membrane against hypotonic solution. Analgesic activity was evaluated by tail immersion method for central mechanism and by formalin-induced lick test for peripheral mechanism in mice. In tail immersion method, all the solvent fractions of L. spinosa at a dose of 500 mg/kg body weight exhibited a significant (p<0.05) elongation in pain reaction time. In peripheral analgesic activity test, the chloroform fraction at a dose of 500 mg/kg body weight inhibited a maximum of 35.44% licking response induced by formalin, as compared to the standard aspirin (53.22%). In the hypoglycemic activity test, all the fractions showed a moderate effect in reducing the blood glucose level in mice treated with 10% glucose. In conclusion, the plant L. spinosa can be considered as a promising source of bioactive compounds for the development of new phytomedicine. Dhaka Univ. J. Pharm. Sci. 20(1): 111-119, 2021 (June)

show abstract

Section: Peripheral Analgesic Activitymentioning

confidence: 99%

In vitro and in vivo Evaluation of Pharmacological Potential of Lasia spinosa Linn.

Chowdhury

Ibrahim

Shahadat

et al. 2021

Dhaka Univ. J. Pharm. Sci

View full text Add to dashboard Cite

show abstract

“…It is extensively planted in the northern part of Bangladesh and all over India, Pakistan and Myanmar. It is frequently grown with the weed and even in the canal escapes of irrigated agricultural area in cold season (12). The ripe dried seed of A. sowa is longer.…”

Section: Introductionmentioning

confidence: 99%

“…Dill-apiol and essential oil derived from seed have insecticidal, ovicidal and synergistic activity against flour beetles (13,14,15). Moreover essential oils have antioxidant and antimicrobial activities (12). Ethanol extract of the stem has antioxidant, antifungal and insecticidal activities (16,17,18).…”

Section: Introductionmentioning

confidence: 99%

Four bioactive compounds isolated from the stem of Anethum sowa L. and their bioactivities

2023

View full text Add to dashboard Cite

Anethum sowa Roxb., (a well-known herb in folk medicine, has a greater medicinal significance due to its diversified activities such as antioxidant, antimicrobial and antispasmodic activity. Very few bioactive compounds have been reported from this species. Our study focused on the isolation, structure elucidation and bioactivity assay of the compounds. In the present work, 6-hydroxy-1, 3-dimethoxy-7-methyl-xanthen-9-one (AS-1) from dichloromethane extract and scopoletin (AS-2), 1, 3, 4-trimethoxy-xanthen-9-one (AS-3), graveolone (AS-4) from ethyl acetate extract of stem of A. sowa were isolated from the stem as well as the plant for the first time. All the characterizations and chemical structures of the compounds were determined by extensive modern spectroscopic techniques such as ultraviolet (UV), infrared (IR), mass, Nuclear Magnetic Resonance (NMR) spectrophotometer. Moreover, the cytotoxic, antimicrobial and antioxidant activity of AS-2, AS-3 and AS-4 were assessed. AS-2 exhibited significant activity against Salmonella typhi while mild antifungal activity against Aspergillus niger. Furthermore AS-3 revealed significant antifungal activity against Sacharomyces cerevacae as well as antibacterial activity against Salmonella typhi. Besides AS-4 exhibited moderate antibacterial activity against Bacillus megaterium. In addition AS-2, AS-3 and AS-4 presented mild cytotoxic with respect to positive control (Vincristine sulphate) while AS-3 exhibited moderate antioxidant activity as compared to positive control (Ascorbic acid).

show abstract

“…The transmission of pain impulses to the brain, where they can be modified by a variety of variables, is mediated by certain nerve fibers. By working on the sensory nerve system, analgesic drugs delay or eliminate analgesia or pain without appreciably affecting awareness [3].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Studies, GC-MS Analysis and In vivo Analgesic, Anti-inflammatory and Antidiarrheal Activity of Chaerophyllum villosum Wall. ex Dc. and Achillia millefolium L

Adil,

Dastagir,

Filimban

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Chaerophyllum villosum (Ganjari) and Achillea millefolium L. (Yarrow) are highly medicinal plants widely used in both folk and official medicine. Materials and Methods: The analgesic activities of C. villosum and A. millefolium were evaluated by hot plate method and acetic acid-induced writhing test, the anti-inflammatory activities were evaluated by carrageenan-induced paw oedema method and antidiarrheal activity was carried out by charcoal meal test. Results: The quantitative phytochemical analysis and gas chromatography-mass spectrometry analysis of both plants showed several phytoconstituents including alkaloids, phenols, tannins, flavonoids, saponin, terpenoids with highest concentration of Tri tetracontane (7.52%) and methyl stearate (8.5%) in methanolic and chloroformic extract of C. Villosum respectively. Octadecanal (6.21%) and n-hexadecanoic acid (10.6%) were showing maximum concentration in methanolic and chloroformic extract of A. millefolium respectively. The chloroformic extract of A. millefolium showed higher (25.33 ± 4.72) peripheral analgesic activities at 300 mg/kg. The chloroformic extract of Chaerophyllum villosum exhibited higher (11.56 ± 0.15) central analgesic activities at 300 mg/kg. In antidiarrheal activity the methanolic extract of Chaerophyllum villosum highly (17.06 ± 1.5) inhibited charcoal movement at 300 mg/kg. In anti-inflammatory activities the chloroformic extract of Chaerophyllum villosum at 300 mg/kg showed high inhibition in the paw volume (1.09 ± 0.04) after 5 hours of induction of carrageenan. Conclusion: The results suggested that Chaerophyllum villosum and Acheilia millefolium exhibited significant peripheral and central analgesic activity, anti-inflammatory and antidiarrheal activity which elucidated its use in the treatment of pain, inflammation and gastrointestinal disorders.

show abstract

Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

Cited by 3 publications

References 12 publications

In vitro and in vivo Evaluation of Pharmacological Potential of Lasia spinosa Linn.

In vitro and in vivo Evaluation of Pharmacological Potential of Lasia spinosa Linn.

Four bioactive compounds isolated from the stem of Anethum sowa L. and their bioactivities

Phytochemical Studies, GC-MS Analysis and In vivo Analgesic, Anti-inflammatory and Antidiarrheal Activity of Chaerophyllum villosum Wall. ex Dc. and Achillia millefolium L

Contact Info

Product

Resources

About