Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats

Lahlou, Sanaa; Tahraoui, Adel; Israili, Zafar H.; Lyoussi, Badiaâ

doi:10.1016/j.jep.2006.10.005

Cited by 125 publications

(102 citation statements)

References 20 publications

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“…In addition, Cs perfusion incresaed urinary sodium, chloride and potassium levels suggesting a probable inhibition of Na+/K+/2Cl-commonly named as Furosemide like effect. Previous studies have been reported similar diuretic mechanism of plants extract [2,[20][21][22] . We have previously demonstrated that the increase of diuresis was accompanied by a similar qualitative increase of electrolytes after Spergularia purpurea and Retama reatam water extract treatment [9,23] .…”

Section: Discussionmentioning

confidence: 53%

“…Our recent work demonstrated that Cs perfusion reduced mean arterial blood pressure in anaesthetized normal rats (data not shown), this effect may be partially be due to the observed diuretic effect. However, the increase in the creatinine levels must be taken with care since it may be due the a probable renal toxicity [20] . In addition, Cs perfusion incresaed urinary sodium, chloride and potassium levels suggesting a probable inhibition of Na+/K+/2Cl-commonly named as Furosemide like effect.…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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Abstract:The purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg −1 h −1 in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cl-and K + were significantly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg −1 h −1 had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Cl-urinary excretion in normal rat. This effect may be mediated via a Furosemide like effect.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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“…The diuretic capability of plants has been described in previous studies with other medicinal plants (Benjumea et al, 2005;Lahlou et al, 2007;Martín-Herrera et al, 2007;Adam et al, 2009;Amuthan et al, 2012). However, the mechanism of action of these has not been elucidated because of aqueous or organic extracts with biological activity, are a mixture of compounds may be working by synergism and some hypotheses have been formulated in order to explain medical properties of plants.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the presence of polar organic compounds as flavonoid glycosides and saponosids in plants can produce diuresis because they are more likely to have contact with renal tissues (Lahlou et al, 2007;Adam et al, 2009;Amuthan et al, 2012;Meléndez-Camargo et al, 2014). Natural compounds in medicinal plants might stimulate the regional blood flow and/or promote an initial vasodilatation as do the osmotic diuretics and xanthenes (Osswald and Schnermann, 2011;Saleem et al, 2015), but might also produce inhibition of renal tubular reabsorption of water and anions (Abdala et al, 2012;Gasparotto et al, 2011); the result in these cases is diuresis.…”

Section: Discussionmentioning

confidence: 99%

Diuretic activity of the bark of Eysenhardtia polystachya

Pablo-Pérez

Estévez-Carmona

Meléndez-Camargo

2016

Bangladesh J Pharmacol

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The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle were administered per os to female rats (n=6 animals per group). After 6 hours in metabolic cages, the effect on urinary flow, glomerular ﬁltration rate and electrolyte balance of sodium and potassium were assessed in all animals. E. polystachya at the doses of 500 and 750 mg/kg induced diuretic activity, since markedly increased (p<0.05) the urinary flow rate, similar to that of furosemide treated group. Only the dose of 750 mg/kg produced an increment in urinary excretion of sodium but not of potassium compared with control group. These findings indicate that E. polystachya bark-induced diuretic activity, providing evidence for its folkloric use.

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“…Estudos químicos e farmacológicos de extratos obtidos de T. vulgare tem demonstrado seu potencial biológico antiinflamatório (Schinella et al, 1998;William, 1999), antibacteriano e antifúngico (Pessini et al, 2003), antimalárico (Jansen, 2006), antiviral (Álvarez et al, 2011), com atividade diurética (Lahlou et al, 2007) e também demonstrou ótimos valores de inibição do crescimento in vitro para L. amazonensis e Trypanosoma cruzi (Luize et al, 2005).…”

Section: Introductionunclassified

Avaliação da atividade antileishmania in vitro de Tanacetum vulgare (Asteraceae)

et al. 2017

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ResumoA Leishmaniose é considerada uma doença negligenciada. Nos últimos anos estudos tem demonstrado que várias plantas possuem atividade contra esses patógenos, servindo de base para a formulação de fitoterápicos ou como alvo para a obtenção de princípios ativos contra a doença. Esta pesquisa teve como objetivo avaliar a atividade biológica in vitro antileishmania dos extratos hexânicos e metanólicos das flores e folhas de Tanacetum vulgare contra Leishmania amazonensis e Leishmania guyanensis. Foi realizada a extração das flores e folhas do material vegetal a partir dos solventes hexânico e metanólico. The results showed that the extract metanolic of the flower showed activity against L. amazonensis (IC50 = 31.5 μg mL -1 ) and L. guyanensis (IC50 < 100 μg mL -1 ) in 72 h of incubation. Therefore, it is verified that the methanolic extract of the T. vulgare flower performed better in relation to antileishmania activity, allowing the possibility of future studies to determine its therapeutic efficacy.

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Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats

Cited by 125 publications

References 20 publications

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Diuretic activity of the bark of <i>Eysenhardtia polystachya</i>

Avaliação da atividade antileishmania in vitro de Tanacetum vulgare (Asteraceae)

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