DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS

Purwidyaningrum, Ika; Sukandar, Elin Yulinah; Fidrianny, Irda

doi:10.22159/ajpcr.2017.v10s2.19481

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…gave the highest sodium levels which were not significantly different compared to furosemide, while the other groups had a significant difference with furosemide (p<0.05). The potassium levels in all of extracts sample had no significant difference with furosemide [10]. Therefore, this is big opportunity to find a new antihypertensive medicine which safe, effective, and high quality.…”

Section: Introductionmentioning

confidence: 84%

ANTIHYPERTENSIVE ACTIVITY OF EXTRACT AND FRACTIONS OF MATOA (POMETIA PINNATA J. R & G FORTS) LEAVES

Purwidyaningrum

Sukandar²,

Fidrianny³

2017

Asian J Pharm Clin Res

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Objective: The purpose of this study was to determine antihypertensive activity of extract and fractions of matoa (Pometia pinnata) leaves.Methods: Matoa leaves were extracted by reflux, followed by evaporating using rotary evaporator. Hypertension was induced by 50 mg/kg bw. NaCl and 1.5 mg/kg bw. prednisone orally, every day as long as 28 days, then continued over the next 28 days in the therapy period. Male Sprague Dawley rats were divided into 12 groups which were hydrochlorothiazide (0.45 mg/kg bw.), control group hypertensive, control normal, matoa leaves extract (MLE) (with doses of 50 mg/kg bw., 100 mg/kg bw., and 150 mg/kg bw.), ethylacetate fraction (with doses of 4.35 mg/kg bw., 8.71 mg/kg bw., and 13.06 mg/kg bw.), and water fraction (with doses of 10 mg/kg bw., 21.88 mg/kg bw., and 32.82 mg/kg bw.). Measurement of systolic and diastolic blood pressure was done every weeks using direct tail-cuff of noninvasive method. Then histomorphology of muscle heart was performed at the end of this research.Results: Ethylacetate fraction of matoa leaves 13.08 mg/kg bw. and MLE 150 mg/kg bw. gave significant result in lowering blood pressure (p<0.05) on the 28 th day of therapy and showed an equal profile with hydrochlorothiazide (0.45 mg/kg bw). Histomorphological result of rat's muscle heart found collagen production was increased in NaCl-prednisone induced rats.Conclusions: Extract and fractions of P. pinnata leaves could decrease blood pressure of NaCl-prednisone induced hypertension rats, but this effect was not liniear with doses and they did not decrease the collagen production in cardiac myocardium compared to normal group.

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Section: Introductionmentioning

confidence: 84%

ANTIHYPERTENSIVE ACTIVITY OF EXTRACT AND FRACTIONS OF MATOA (POMETIA PINNATA J. R & G FORTS) LEAVES

Purwidyaningrum

Sukandar²,

Fidrianny³

2017

Asian J Pharm Clin Res

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“…Mencit diadaptasi selama 7 hari, kemudian dipuasakan selama 12 jam tanpa makan tetapi tetap diberikan air minum dan 2 jam sebelum perlakuan air minum dihentikan. Mencit diberikan air hangat secara per oral sebanyak 0,4 ml/20gBB (14) . Volume yang diberikan pada kelompok perlakuan sebanyak 0,2 ml/20gBB mencit.…”

Section: Pengujian Efek Diuretik Terhadap Mencit Jantan Galur Swissunclassified

Perbandingan Aktivitas Diuretik pada Berbagai Produk Seduhan Teh Hijau(Camellia sinensis L.)

Susilowati¹,

Ramadhan²

2021

Maj. Farmasetika

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Hipertensi merupakan masalah kesehatan yang berbahaya karena memiliki faktor resiko yang mengarah pada penyakit kardiovaskuler. Penggunaan diuretik berperan dalam terapi pengobatan seperti hipertensi, gagal jantung, serta edema. Diketahui bahwa teh hijau dapat berkhasiat sebagai diuretik. Penelitian ini bertujuan mengetahui perbandingan aktivitas diuretik pada berbagai produk teh hijau (Camellia sinensis L.). Pada uji aktivitas diuretik, 30 ekor mencit di bagi menjadi 6 kelompok yang terdiri dari kelompok I (CMC. Na 1%), Kelompok II (Furosemid), Kelompok III, IV, V dan VI merupakan kelompok perlakuan yang terdiri dari pemberian seduhan White Tea, Yellow Tea, Black Dragon Tea Dan Green Tea Premium dengan dosis 2g, 4g dan 6g yang diseduh dengan 200ml air suhu 70οC selama 5-15 menit. Pengukuran urin dilakukan setiap 1 jam selama 6 jam. Analisa data dilakukan dengan menggunakan spss versi 26 dengan taraf kepercayaan 95%. Seduhan white tea, yellow tea, dan black dragon tea pada dosis 2g tidak memiliki efek diuretik (p>0,05) sedangkan green tea premium 2g memiliki aktivitas diuretik namun lebih rendah dibandingkan dengan furosemid. Pada dosis 4g, white tea, yellow tea dan green tea premium memiliki aktivitas sebagai diuretik (p<0,05) namun masih lebih rendah dibandingkan dengan furosemid. Pada dosis 6g, white tea, yellow tea, black dragon tea memiliki aktivitas sebagai diuretik (p<0,05) namun masih lebih rendah dibandingkan dengan furosemid, sedangkan green tea premium dosis 6g memiliki aktivitas diuretik yang sebanding dengan furosemid (p>0,05). Dapat disimpulkan bahwa white tea, yellow tea, black dragon tea, dan green tea premium dosis 6g memiliki aktivitas diuretik.

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“…Group I : Negative control group was given 1% Na-CMC Group II : Positive control group received furosemide at a dose of 5.2 mg/kg BW Group III : Ethanol extract of green tea leaves at a dose of 70 mg/kg BW Group IV : Infusion of green tea leaves at a dose of 70 mg/kg BW The test animals were acclimatized for seven days in laboratory conditions, then fasted for 12 hours from food but still given access to water until two hours before receiving the treatment. Afterward, they were weighed and given warm water orally as much as 0.4 ml/20g BW (Purwidyaningrum et al, 2016). In Hour 0, all groups received their respective treatment orally.…”

Section: Experimental Protocolmentioning

confidence: 99%

Comparative effectiveness of the ethanol extract and infusion of green tea leaves (Camellia Sinensis L.) as a diuretic in male swiss mice

Susilowati¹,

Indratika²

2020

Pharmaciana

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Green tea (Camellia sinensis L.) contains flavonoid compounds and methylxanthine and has proven efficacy as a diuretic. The dosage form is among the factors determining the biological effects of a drug. This experimental study set out to determine the effectiveness of the ethanol extract and infusion of green tea leaves as a diuretic in male Swiss mice. A total of 20 male Swiss mice were divided into four groups receiving different daily treatments: group I (given 1% Na-CMC), group II (furosemide at a dose of 5.2 mg/kg BW), group III (ethanol extract of green tea leaves at a dose 70 mg/kg BW), and group IV (green tea leaf infusion at a dose of 70mg/kg BW). Before the treatment, all groups were given warm water orally (0.4 mL/20g BW), then the effects of diuretics were measured from urine volume for six hours. The data were analyzed statistically by one-way analysis of variance (ANOVA), followed by LSD comparison tests, with statistically significant p<0.05. Based on the phytochemical screening results, the ethanol extract and infusion of green tea leaves contained alkaloids, flavonoids, and tannins. The mean cumulative urine volume in group I was 0.260±0.185 mL, group II 0.869±0.162 mL, group III 0.866±0.197 mL, and group IV 0.642±0.187 mL. Compared to furosemide, the diuretic activity of the ethanol extract of green tea leaves (0.997±0.182) was not significantly different (p>0.05) from that of the green tea leaf infusion (0.739±0.182). In conclusion, green tea leaves can be used as diuretics in two dosage forms, namely extract and infusion.

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DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS

Cited by 11 publications

References 7 publications

ANTIHYPERTENSIVE ACTIVITY OF EXTRACT AND FRACTIONS OF MATOA (POMETIA PINNATA J. R & G FORTS) LEAVES

ANTIHYPERTENSIVE ACTIVITY OF EXTRACT AND FRACTIONS OF MATOA (POMETIA PINNATA J. R & G FORTS) LEAVES

Perbandingan Aktivitas Diuretik pada Berbagai Produk Seduhan Teh Hijau(Camellia sinensis L.)

Comparative effectiveness of the ethanol extract and infusion of green tea leaves (Camellia Sinensis L.) as a diuretic in male swiss mice

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