Diterpenoid alkaloids from the root of <i>Aconitum sinchiangense</i> W. T. Wang with their antitumor and antibacterial activities

Liang, Xiaoxia; Chen, Lan; Song, Lei; Fei, Wenbo; He, Min; He, Chao; Yin, Zhongqiong

doi:10.1080/14786419.2016.1272113

Cited by 32 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some Aconitum species are highly toxic because of aconite alkaloid, many species are essential in the formulation of traditional herbal medicine in Asia ( Zhao et al, 2010 ; Semenov et al, 2016 ; Wada et al, 2016 ; Liang et al, 2017 ). The current state of Aconitum phylogenetics lacks molecular information of some species in Eastern Asia, and thus inhibits identification and germplasm utilization of this genus.…”

Section: Introductionmentioning

confidence: 99%

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus

Kong

Liu

Yao

et al. 2017

PeerJ

View full text Add to dashboard Cite

The herbal medicinal genus Aconitum L., belonging to the Ranunculaceae family, represents the earliest diverging lineage within the eudicots. It currently comprises of two subgenera, A. subgenus Lycoctonum and A. subg. Aconitum. The complete chloroplast (cp) genome sequences were characterized in three species: A. angustius, A. finetianum, and A. sinomontanum in subg. Lycoctonum and compared to other Aconitum species to clarify their phylogenetic relationship and provide molecular information for utilization of Aconitum species particularly in Eastern Asia. The length of the chloroplast genome sequences were 156,109 bp in A. angustius, 155,625 bp in A. finetianum and 157,215 bp in A. sinomontanum, with each species possessing 126 genes with 84 protein coding genes (PCGs). While genomic rearrangements were absent, structural variation was detected in the LSC/IR/SSC boundaries. Five pseudogenes were identified, among which Ψrps19 and Ψycf1 were in the LSC/IR/SSC boundaries, Ψrps16 and ΨinfA in the LSC region, and Ψycf15 in the IRb region. The nucleotide variability (Pi) of Aconitum was estimated to be 0.00549, with comparably higher variations in the LSC and SSC than the IR regions. Eight intergenic regions were revealed to be highly variable and a total of 58–62 simple sequence repeats (SSRs) were detected in all three species. More than 80% of SSRs were present in the LSC region. Altogether, 64.41% and 46.81% of SSRs are mononucleotides in subg. Lycoctonum and subg. Aconitum, respectively, while a higher percentage of di-, tri-, tetra-, and penta- SSRs were present in subg. Aconitum. Most species of subg. Aconitum in Eastern Asia were first used for phylogenetic analyses. The availability of the complete cp genome sequences of these species in subg. Lycoctonum will benefit future phylogenetic analyses and aid in germplasm utilization in Aconitum species.

show abstract

Section: Introductionmentioning

confidence: 99%

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus

Kong

Liu

Yao

et al. 2017

PeerJ

View full text Add to dashboard Cite

show abstract

“…9) from Aconitum sinchiangense W. T. Wang; 59 and 60 showed signicant cytotoxicity activities against tumor cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC 50 values comparable to that of cisplatin. 33,34 2.2.2 The structure-cytotoxicity activity relationships of C 19 -diterpenoid alkaloids. From 2008 to 2018, more than 100 C 19 -diterpenoid alkaloids were studied for their cytotoxicity activities.…”

Section: Progress In the Cytotoxicity Research Of C 19 -Diterpenoid Amentioning

confidence: 99%

Two decades of advances in diterpenoid alkaloids with cytotoxicity activities

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…In previous reports, eight diterpene alkaloids from this plant have been isolated and identified (Li & Chen 1994a, 1994b. The diterpenoid alkaloids are the characteric ingredients displaying various bioactivities (Yin et al 2014;Shyaula et al 2015;Chen et al 2016;Liang et al 2017). However, the bioactivities have not been studied yet, which prompted us to undertake a systematic study of this plant.…”

Section: Introductionmentioning

confidence: 99%

Diterpenoid alkaloids from Aconitum brevicalcaratum as autophagy inducers

Jiang

Huang

Gao

et al. 2018

Natural Product Research

View full text Add to dashboard Cite

A new C diterpenoid alkaloid, brevicanine (1) and six known ones (2-7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures were elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity of those compounds was investigated against HCT116 human cancer cell line, which showed none of them possessing considerable anti-proliferative activities. To evaluate the autophagy effect of compounds 1-7, Western blot was used to detect the expression of autophagic marker by stimulating human cancer HCT116 cells. The results showed that compound 6 induced protective autophagy in HCT116 cells. Mechanistic insight showed that compound 6 induced protective autophagy through p53 activation, ERK1/2 and p38 MAPK signaling cascade.

show abstract

Diterpenoid alkaloids from the root of Aconitum sinchiangense W. T. Wang with their antitumor and antibacterial activities

Cited by 32 publications

References 28 publications

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus

Two decades of advances in diterpenoid alkaloids with cytotoxicity activities

Diterpenoid alkaloids from Aconitum brevicalcaratum as autophagy inducers

Contact Info

Product

Resources

About