Diterpenoid Alkaloids from Consolida oliveriana

Abstract

From the aerial parts of Consolida oliveriana (DC) Schröd. a new norditerpenoid alkaloid consolidine (2) has been isolated, in addition to the known alkaloids pubescenine (1), gigactonine, and delsoline and the diterpenoid alkaloid ajaconine (4). The structure of alkaloid 2 was established on the basis of its physical and spectroscopic data including detailed NMR studies. A detailed NMR study on ajaconine (4) resulted in the revision of 11 13C chemical shift assignments.

Diterpenoid and steroidal alkaloids

“…Alkaloids of Consolida oliveriana (DC) Schröd. Isolation and structure elucidation of a new norditerpenoid alkaloid consolidine (20) has been reported by Ulubelen et al from the aerial parts of Consolida oliveriana (DC) Schröd collected from southern Turkey. They have also isolated the known alkaloids pubescenine, gigactonine, delsoline and ajaconine.…”

A systematic review on the chemical constituents of the genus Consolida (Ranunculaceae) and their biological activities

“…6,7 In addition, Consolida plants can also be used externally against body lice. 8 Generally, the medicinal uses of Consolida plants are similar to plants from its highly related genus Delphinium, as they are similar in chemical composition.…”

Cytotoxic Activities of Flavonoid Glycoside Acetates from Consolida oliveriana

“…Consolida, a highly specialized genus of Ranunculaceae closely allied to Delphinium with its center of diversity in Anatolia, is like its relatives a rich source of alkaloids. Previous studies of the aerial parts of Consolida oliveriana (DC) Schrod., a species used medicinally in parts of Anatolia, have concentrated on the isolation of its constituent alkaloids [1], [2]. A large number of publications has dealt with the diterpenoid alkaloids of other Consolida species but reports on the flavonoid content of members of this genus are sparse [3], [4].…”