A systematic review on the chemical constituents of the genus Consolida (Ranunculaceae) and their biological activities

Abstract

Multiple constituents from Consolida species showed great research significance for their novel structures and broad bioactivities.

Anti-helminthic Activity of Consolida orientalis (Gay) Schröd. on Caenorhabditis elegans Nematodes and Determination of Possible Active Ingredients

“…There are many studies in the literature on the anthelmintic activity of various plant extracts (Garbin et al, 2021;Lima et al, 2021). Ethnobotanical studies have shown that Consolida species are commonly used as anthelmintic plants in some countries such as Turkey and China (Yin et al, 2020). In addition, the anthelmintic effect of ethanol extracts on Ascaris suum's eggs and infectious larvae of Trichostrongylus colubriformis was investigated in the Czech Republic of a total of 16 plants, including Consolida regalis.…”

“…It can grow on steppes, deserts and even drystoned slopes. This genus is spreading around the world in Southern Europe, North Africa, West Asia, and Anatolia (Yin et al, 2020). C. orientalis, popularly known as "Purple Flower" in Turkey, has natural spread in southern Europe, Turkey, and North Africa.…”

Chemistry and biological activities of hetisine-type diterpenoid alkaloids

“…39,[69][70][71][72][73] It is also noteworthy that hetisine-type DAs from Spiraea plants possess relatively few and simple oxygenated substituents: they usually possess only one or two hydroxyl or ketone carbonyl substituents at C-6, C-11, and C-13, which is of chemotaxonomic signicance. 3 In addition, hetisine-type DAs have been found in plants of the genera Rumex and Polygonum in the family Polygonaceae, including orientinine (79), panicudine (106), and acorientine (115) from Rumex pictus 74 and panicudine (106) from Polygonum aviculare. 20 Hetisine-type DA is the only type of DA that has been found in the polygonaceae family, which widens the distribution of DAs.…”

“…Diterpenoid alkaloids (DAs) are a large group of highly specialized metabolites that are distributed mainly in plants from the genera Aconitum, Delphinium, and Consolida in the Ranunculaceae family, as well as the genus Spiraea in the Rosaceae family. [1][2][3] For centuries, the complex structures and multiple prominent pharmacological activities of DAs have attracted extensive and lasting attention from scientists. [4][5][6] DAs are the active components of several widely used traditional Chinese medicines (TCMs) from Ranunculaceae, such as Fuzi (Aconitum carmichaelii), which has been used medicinally for thousands of years in China and other Asian countries [7][8][9] .…”

C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

“…In many countries and regions, mainly in the Mediterranean and Asia, various Delphineae plants have been extensively employed as herbal medicines for thousands of years to treat multiple kinds of diseases, including rheumatism, traumatic injury, inuenza, oedema, enteritis and stomach ache, fainting, various tumors, asthma, skin diseases such as ringworm and scabies, sciatica, migraine, arthralgia, toothache, neuralgia, and other kinds of pain. [7][8][9] Especially in China, in addition to two Aconitum species officially listed in the Chinese Pharmacopoeia (A. carmichaelii Debeaux and A. kusnezoffii Reichb. ), at least 76 species of Aconitum and 32 species of Delphinium are used as folk medicines due to their unique and proven therapeutic effects.…”