Disturbed left atrial mechanical function in paroxysmal atrial fibrillation: A speckle tracking study

Henein, Mark; Zhao, Ying; Henein, Michael Y.; Lindqvist, Per

doi:10.1016/j.ijcard.2011.10.007

Cited by 42 publications

(35 citation statements)

References 20 publications

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“…Additionally, the atrial emptying pattern is strongly affected by LV diastolic properties [17,18]. It has been demonstrated that in diabetic patients, decreased LA passive emptying volume is related to increased LVEDP and increased LA active emptying volume is associated with compensatory mechanisms in LA contraction [15].…”

Section: Atrial Mechanical Functions In Diabetes Mellitusmentioning

confidence: 99%

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Fu¹,

Liu²,

Li³

et al. 2013

Cardiol J.

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Section: Atrial Mechanical Functions In Diabetes Mellitusmentioning

confidence: 99%

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Fu¹,

Liu²,

Li³

et al. 2013

Cardiol J.

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“…E/e' ratio 10.0 ± 2.6 5.9 ± 1.8 < 0.001 E -peak early diastolic filling velocity; A -peak late diastolic filling velocity; e' -peak early diastolic velocity of the mitral annulus; a' -peak late diastolic velocity of the mitral annulus In previously published studies, global LA strain and strain rate were significantly reduced in patients with paroxysmal AF, compared with the normal control subjects [21,22].…”

Section: Discussionmentioning

confidence: 90%

Left atrial mechanical function and stiffness in patients with atrial septal aneurysm: A speckle tracking study

2015

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“…This may imply LA functional remodeling caused by atrial fibrosis was still in the beginning stages and has yet to reach an extent that is sufficient to increase the galectin-3 concentrations. E/A ratio was associated with LAS4 and SR, suggesting a direct relationship between the extent of increase in LA pressure and the degree of cavity dysfunction (10) .…”

Section: Discussionmentioning

confidence: 91%

Galectin-3 in Middle-Aged Patients with First Episode of Non-valvular Atrial Fibrillation: a Speckle-tracking Study

Kılıçgedik¹,

Efe²,

Gürbüz³

et al. 2017

Kosuyolu Heart Journal

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Introduction: Recent studies have shown a significant association between left atrial (LA) global longitudinal strain (GLS) and the progression of atrial fibrillation (AF) with significantly decreased LA GLS in patients with paroxysmal AF. Significantly higher levels of serum galectin-3 have also been found in patients with non-valvular AF. This study aimed to examine the relationship of the early stage of atrial fibrosis and reduced atrial deformation with serum galectin-3 concentration in middle-aged patients with a first episode of nonvalvular AF. Patients and Methods:This study prospectively enrolled 34 patients who were admitted to our emergency department and required either a medical or electrical cardioversion due to the first episode of AF, without any structural or coronary heart disease and with normal LA size. Additionally, 31 control subjects were also enrolled. The diameter, volume, and mechanical function of LA, including strain (S) and strain rate (SR), and serum galectin-3 levels were measured. Results:The average age was 48.5 ± 10.4 years. Galectin-3 values were not significantly different between the AF and control groups (r= 0.42; p= 0.51) and were found to correlate inversely with peak negative SR on apical four chamber (r= −0.31, p= 0.02) and two chamber (r= −0.25, p= 0.04) views. In comparison to the control group, the AF group had significantly lower values of peak systolic S on four chamber view (p= 0.037), peak late diastolic S (p= 0.04), peak positive SR on apical four-chamber view (p= 0.04), and peak late negative SR on apical four chamber (p= 0.03) and two-chamber (p= 0.02) views. Conclusion:Middle-aged patients with the first episode of AF and normal LA sizes had reduced LA reservoir and active atrial functions. Although beginning signs of LA functional remodeling were shown on S and SR imaging, these were not completely reflected by serum galectin-3 levels.Key Words: Atrial fibrillation; strain; strain rate; galectin-3 İlk Atak Non-valvular Atrial Fibrilasyonlu Orta Yaşlı Hastalarda Galectin-3 ÖZET Giriş: Biz bu çalışmada ilk atak non-valvular atriyal fibrilasyon (AF)'lu orta yaşlı hasta grubunda serum galectin konsantrasyonu ile AF erken evresi arasındaki ilişkiyi araştırdık. Hastalar ve Yöntem:Bu çalışmaya acil servisimize ilk atak AF ile başvuran, medikal ya da elektriki kardiyoversiyon yapılmış, yapısal ya da koroner kalp hastalığı olmayan normal LA boyuta sahip 34 hasta ve 31 kontrol hastası prospektif olarak dahil edildi. Ekokardiyografik bulgular kayıt altına alındı ve serum galectin düzeyleri ekokardiyografi öncesi alınan kan örneklerinden ölçüldü. Bulgular:Hastaların ortalama yaşı 48.5 ± 10.4 yıldı. Galectin değerleri arasında AF ve kontrol grubu arasında anlamlı fark saptanmadı (r= 0.42 ; p= 0.51) ve apikal dört boşluk (r= -0.31, p= 0.02) ve iki boşluk görüntü-den (r= -0.25 , p= 0.04) pik negatif SR ile negatif korele bulundu. Kontrol grubu ile karşılaştırıldığında, AF grubunda dört boşluk görüntüden pik sistolik strain (p= 0.037), pik geç diastolik strain (p= 0.0...

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Disturbed left atrial mechanical function in paroxysmal atrial fibrillation: A speckle tracking study

Cited by 42 publications

References 20 publications

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Left atrial mechanical function and stiffness in patients with atrial septal aneurysm: A speckle tracking study

Galectin-3 in Middle-Aged Patients with First Episode of Non-valvular Atrial Fibrillation: a Speckle-tracking Study

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