Left atrial mechanical function and stiffness in patients with atrial septal aneurysm: A speckle tracking study

Demir, Mehmet; Aktaş, İbrahim; Çamcı, Sencer

doi:10.5603/cj.a2015.0033

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…The diagnostic criteria for ASA vary, with no uniform consensus achieved [8][9][10] (Table 1). Recent studies have defined ASA through excursion ratios in isolation [11], atrial septal protrusion distances in isolation [3,8,12,13], and combinations of septal protrusion distance and interatrial septum base diameter [1,2,[14][15][16][17], with values ranging from .10 mm to .15 mm [1][2][3]8,[12][13][14][15][16][17]. In addition, some authors have separated septal hypermobility (increased phasic septal excursion, Figure 1) from a septal aneurysm (increased protrusion of the dilated segment, Figures 2 and 3) [17][18][19], whereas other studies have included both as ASAs [20].…”

Section: Definitionsmentioning

confidence: 99%

Atrial Septal Aneurysms – A Clinically Relevant Enigma?

Cho

Feneley

Holloway

2022

Heart, Lung and Circulation

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Section: Definitionsmentioning

confidence: 99%

Atrial Septal Aneurysms – A Clinically Relevant Enigma?

Cho

Feneley

Holloway

2022

Heart, Lung and Circulation

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“…">Technical challenges during LA image acquisition. For example, LA strain is affected by the presence of atrial septal aneurysms 88 . Also, the inclusion of the LA roof in image analysis has been debated as it often includes the pulmonary venous structures with transverse muscular bundles in the region providing no additional information to LA longitudinal deformation 65…”

Section: Identification Of Atrial Fibrosismentioning

confidence: 99%

Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards

Quah

Dharmaprani

Tiver

et al. 2021

Cardiovasc electrophysiol

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Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical practice. However, current therapeutic interventions for atrial fibrillation have limited clinical efficacy as a consequence of major knowledge gaps in the mechanisms sustaining atrial fibrillation. From a mechanistic perspective, there is increasing evidence that atrial fibrosis plays a central role in the maintenance and perpetuation of atrial fibrillation. Electrophysiologically, atrial fibrosis results in alterations in conduction velocity, cellular refractoriness, and produces conduction block promoting meandering, unstable wavelets and micro‐reentrant circuits. Clinically, atrial fibrosis has also linked to poor clinical outcomes including AF‐related thromboembolic complications and arrhythmia recurrences post catheter ablation. In this article, we review the pathophysiology behind the formation of fibrosis as AF progresses, the role of fibrosis in arrhythmogenesis, surrogate markers for detection of fibrosis using cardiac magnetic resonance imaging, echocardiography and electroanatomic mapping, along with their respective limitations. We then proceed to review the current evidence behind therapeutic interventions targeting atrial fibrosis, including drugs and substrate‐based catheter ablation therapies followed by the potential future use of electro phenotyping for AF characterization to overcome the limitations of contemporary substrate‐based methodologies.

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“…[ 6 ] However, the current evidence is not sufficient to indicate the thrombus source of paradoxical embolism. [ 7 ] Some studies [ 5 , 8 , 9 ] have shown that left atrial dysfunction, such as interatrial block which can be caused by anatomic abnormality of the atrial septum, may be one of possible contributors of atrial septal abnormalities leading to ischemic events. Atrial vulnerability was defined by the prolongation of effective refractory period and atrial conduction time in electrophysiology, including interatrial block and biphasic P waves, and inducible atrial arrhythmia.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the association of atrial septal abnormalities and atrial vulnerability

Sun

Zhou²,

Xu³

et al. 2021

Medicine

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Background: The mechanism of cryptogenic stroke (CS) in patients with atrial septal abnormalities remains unclear, and the increased incidence of atrial vulnerability may be one of the reasons. We performed this meta-analysis to clarify the association between atrial septal abnormalities and atrial vulnerability, and to provide evidence-based basis for the prevention and mechanism of CS. Methods: We systematically searched for studies on the association between atrial septal abnormalities and atrial vulnerability, and pooled available data on types of atrial septal abnormalities, types of atrial vulnerability, and methods of atrial vulnerability detection. The primary endpoints were the occurrence of atrial arrhythmias or P wave abnormalities. Random-effects models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: Twelve case-control studies were eligible. Compared with the control group, patients with atrial septal abnormalities had a higher risk of atrial vulnerability (OR: 1.93; 95% CI: 1.13-3.30, P = .02). Data based on stroke patients showed that the group with atrial septal abnormalities had a higher risk of atrial vulnerability than the control group (OR: 2.00; 95% CI: 1.13–3.53, P = .02). However, there was no significant difference in the incidence of atrial vulnerability between the 2 groups of nonstroke patients. Subgroup analysis showed that although atrial septal abnormality increased the risk of atrial vulnerability in the subgroup of atrial septal aneurysm (OR: 1.68; 95% CI: 0.47–5.95, P = .42), the subgroup of atrial fibrillation (AF)/atrial fluster (OR: 1.81; 95% CI: 0.94–3.46, P = .07) and the subgroup of subcutaneous recording system (OR: 1.33; 95% CI: 0.68–2.61, P = .41), the difference was not statistically significant. Conclusions: Atrial septal abnormalities can increase the risk of atrial vulnerability, and atrial arrhythmia caused by atrial septal abnormalities may be one of the mechanisms of CS.

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Left atrial mechanical function and stiffness in patients with atrial septal aneurysm: A speckle tracking study

Abstract: (Cardiol J 2015; 22, 5: 535-540)

Cited by 8 publications

References 22 publications

Atrial Septal Aneurysms – A Clinically Relevant Enigma?

Atrial Septal Aneurysms – A Clinically Relevant Enigma?

Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards

A meta-analysis of the association of atrial septal abnormalities and atrial vulnerability

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