Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Rosiglitazone Attenuates Atrial Structural Remodeling and Atrial Fibrillation Promotion in Alloxan‐Induced Diabetic Rabbits

“…Recent studies implicate inflammation and oxidative stress in the atrial remodeling and AF development and perpetuation [15][16][17][18]. Therefore, it is reasonable to assume that inflammatory activation and oxidative stress can favor atrial interstitial fibrosis and impaired atrial electromechanical function, facilitating the development and maintenance of AF [4][5][6].…”

“…Interestingly, Kato et al [13] demonstrated an interatrial conduction disturbance resulting from the diabetes-related atrial interstitial fibrosis, suggesting that this would be a key substrate for the initiation of AF. He have previously indicated that hyperglycemia contributes to atrial dilation and interstitial fibrosis, as well as to ionic remodeling, resulting in interatrial conduction delay and increased vulnerability to AF [4,5]. DM has been associated with over-production of reactive oxygen species and reduction in the antioxidant capacity, favoring oxidative tissue damage [14].…”

“…DM has been reported as one of the independent risk factors for the development of AF [2,3]. We have previously shown that atrial interstitial fibrosis and impaired atrial electromechanical function are related to the development of AF in alloxan-induced diabetic rabbits [4,5]. Furthermore, inflammatory activation and oxidative stress may represent common pathophysiological pathways in DM and atrial remodeling [6].…”

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

“…It was demonstrated that atrial electromechanical function (excitation-contraction coupling) is impaired owing to increased atrial fibrosis and interatrial electrical conduction delay [38]. Recently, Ayhan et al examined atrial conduction time and cardiac mechanical function in patients with impaired fasting glucose using tissue Doppler imaging [39].…”

“…Changes in atrial excitation-contraction coupling that occur in DM were recently investigated in an alloxan-induced diabetic rabbit model [38]. It was demonstrated that atrial electromechanical function (excitation-contraction coupling) is impaired owing to increased atrial fibrosis and interatrial electrical conduction delay [38].…”