Distribution of Sarcophytol A in Soft Coral of the<i>Sarcophyton</i>Genus

Koh, Mamoru; Iwanaga, Takeshi; Hatanaka, Masahiro; Nakano, Akio; Morihara, Kazuyuki; Takemura, Kentaro

doi:10.1271/bbb.64.858

Cited by 15 publications

(15 citation statements)

References 8 publications

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“…These data may link all of the main carbons in cembranoid ring of all isolated compounds. The specific configuration of each compound was found with direct H2BC couplings of carbon with C-13 hydroxyl to H-14 (the same couplings with on the other way around) for sarcophytol B (1), H2BC couplings of epoxide between C-12 to H-11 for 11,12-epoxy sarcophytol A (2), tertiary C-14 with hydroxyl for Sarcophytol A, and quaternary C-1 with hydroxyl for Sarcophytol M. All of the isolated compounds in this study was already characterized previously by Kobayashi, Nakagawa, & Mitsuhashi, (1979) and Kobayashi & Osabe (1989 • 11,12-epoxy sarcophytol A (2) • Sarcophytol M (4) The f inding of sarcophytol A as the major cembranoid compound in Sarcophyton sample was also detected by previous study on the same genus, which are S. crassocaule, S. digtitatum, S. infundibuifurme, and S. glaucum (Koh et al, 2000;Tanaka, Yoshida, & Benayahu, 2005). Meanwhile, Sarcophytol M as a minor sarcophytol analogue was also found from a previous study on S. glaucum (Kobayashi & Osabe, 1989).…”

Section: Resultssupporting

confidence: 79%

“…Meanwhile, Sarcophytol M as a minor sarcophytol analogue was also found from a previous study on S. glaucum (Kobayashi & Osabe, 1989). However commonly, sarcophytol A content was only up to 28% w/w from lipid fraction (Koh et al, 2000), while this study found sarcophytol A up to 42%. Moreover, studies on Indonesian tropical Sarcophyton species usually found other type cembranoid analogues, particularly sarcophytoxide/sarcophine (Iswani, Tohir, & Januar, 2014;Putra, M. Y., Saparhadi, Karim, Murniasih, & Swasono, 2017;Januar, Zamani, Soedharma, & Chasanah, 2017b).…”

Section: Resultssupporting

confidence: 71%

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Cembranoids of Soft Coral Sarcophyton from Acidified Coral Reef Environment at Shallow Water CO2 vents in Volcano Island, Banda Neira, Indonesia

Januar

Zamani

Soedharma

et al. 2017

Squalen Bull. Marine Fisheries Postharvest Biotech.

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Cembranoid content in soft coral is known as a chemotype that relate with genotype and environment. This research aimed to characterize the cembranoid Sarcophyton soft coral from the reef that acidified by CO 2 volcanic vents (pH T 7.8) at Volcano Islands waters, Banda-Neira (Indonesia), as a means of predicting the future impact of ocean acidification to the genetic diversity of Sarcophyton soft coral. 30 random colonies were taken, combined, and extracted with ethanol. Cembranoid isolation and identification had been done by high performance liquid chromatography and spectroscopic techniques. Results of the study found sarcophytol derivatives (sarcophytol A, 11,12-epoxy sarcophytol A, sarcophytol B, and sarcophytol M) as the only chemotype in the sample. This may suggest low genetic diversity in the observed Sarcophyton sample. Therefore, it may suggest that even soft coral is known to be resilient to future acidification pressures, the genetic diversity or the production of diverse cytotoxic metabolite may be hampered due to ocean acidification in future climate change adaptation.

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Section: Resultssupporting

confidence: 79%

Section: Resultssupporting

confidence: 71%

Cembranoids of Soft Coral Sarcophyton from Acidified Coral Reef Environment at Shallow Water CO2 vents in Volcano Island, Banda Neira, Indonesia

Januar

Zamani

Soedharma

et al. 2017

Squalen Bull. Marine Fisheries Postharvest Biotech.

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“…Each molecule should also be examined for its biological activity such as feeding deterrence and toxicity against larvae of fouling organisms. Koh et al (2000) reported the distribution of cembranes in seven specimens of Sarcophyton soft corals consisting of three S. glaucum, two S. infundibuliforme, and one each of S. trocheliophorum and S. crassocaule collected from the Ishigaki area. Their results are somewhat different from ours: i.e., sarcophytol A (1) in one of S. infundibuliforme, absence of compound 1 in S. crassocaule, sarcophytonin-A (14) in one each of S. glaucum and S. infundibuliforme.…”

Section: Structures Of Compounds 7 and 12mentioning

confidence: 99%

Chemical diversity of Sarcophyton soft corals in Okinawa

Tanaka¹,

Yoshida²,

Benayahu³

2005

Journal of the Japanese Coral Reef Society

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A total of 279 specimens belonging to nine species of soft corals of the genus Sarcophyton were subjected to chemical study for the diversity of cembrane diterpenes. Following morphological identification, each specimen was examined for metabolites using gradient HPLC, NMR, and other tools. The S. glaucum and S. cinereum species complex was found to be the most abundant and to contain the most diverse metabolites in the Ryukyu Archipelago, Japan. S. trocheliophorum and S. ehrenbergi were moderately abundant and diverse in metabolites, while other all species seemed to be scarce and restricted in metabolites. During this research we encountered two new compounds (7,12), whose structures are described in this report.

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“…Koh et al .’s research showed different individuals of same species contained different types of major cembranoids, and the result indicated the composition of cembranoids in the Sarcophyton genus is related with the location where individual samples collected [2] rather than morphological species. The investigation of metabolites from cultured and wild-type soft coral Klyxum simplex resulted in different diterpenoids.…”

Section: Introductionmentioning

confidence: 99%

NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

Sun

Liu

et al. 2014

Marine Drugs

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Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using 1H-NMR spectroscopy coupled with multivariate statistical analysis at the metabolic level. A partial least-squares discriminant analysis showed clear separation among extracts of soft corals grown in Sanya Bay and Weizhou Island. The specific markers that contributed to discrimination between soft corals in two origins belonged to terpenes, sterols and N-containing compounds. The satisfied precision of classification obtained indicates this approach using combined 1H-NMR and chemometrics is effective to discriminate soft corals collected in different geographical locations. The results revealed that metabolites of soft corals evidently depended on living environmental condition, which would provide valuable information for further relevant coastal marine environment evaluation.

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Distribution of Sarcophytol A in Soft Coral of theSarcophytonGenus

Cited by 15 publications

References 8 publications

Cembranoids of Soft Coral Sarcophyton from Acidified Coral Reef Environment at Shallow Water CO2 vents in Volcano Island, Banda Neira, Indonesia

Cembranoids of Soft Coral Sarcophyton from Acidified Coral Reef Environment at Shallow Water CO2 vents in Volcano Island, Banda Neira, Indonesia

Chemical diversity of Sarcophyton soft corals in Okinawa

NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

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