Distribution of persistent organic pollutants in two different fat compartments from obese individuals

Malarvannan, Govindan; Dirinck, Eveline; Dirtu, Alin C.; Pereira-Fernandes, Anna; Neels, Hugo; Gaal, Luc Van; Blust, Ronny

doi:10.1016/j.envint.2013.02.012

Cited by 73 publications

(56 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We report a positive association between total body levels of POPs and waist circumference. As previously reported by our group (22), the link between waist and adipose tissue levels of POPs was stronger in VAT, compared with SAT, despite the fact that absolute POP levels did not differ statistically between VAT and SAT. Adipose tissue levels of POPs were positively related to the amount of CT-VAT but not significantly related to the amount of CT-SAT.…”

Section: Discussionsupporting

confidence: 62%

“…No difference in serum levels of PCB138 and p,p'-DDE between lean and obese individuals was seen (see Table 1). As described previously (22), no significant differences were found between the absolute levels of POPs in the two sampled adipose tissue compartments. Moreover, we detected a very strong correlation between serum levels and adipose tissue levels of all POPs, with r ranging between 0.95 and 0.97 (P , 0.01) for the PCBs and r 0.99 (P , 0.01) for p,p'-DDE.…”

Section: Pop Levelsmentioning

confidence: 97%

“…The samples were analyzed for 28 PCBs (for a full list, please see Supplementary Table 1) and p,p'-DDE. The analytical methods and quality assurance and quality control for the serum and fat samples have been published previously (14,22). We used both lipid weight-adjusted levels and nonlipid weight-adjusted data.…”

Section: Analyses Of Popsmentioning

confidence: 99%

See 2 more Smart Citations

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

et al. 2014

Self Cite

View full text Add to dashboard Cite

OBJECTIVE The contribution of persistent organic pollutants (POPs) to the pandemic of type 2 diabetes mellitus and obesity has been assumed but remains speculative. Our study aimed at investigating the relationship of POP levels with detailed markers of glucose metabolism and body composition. RESEARCH DESIGN AND METHODS Glucose tolerance was determined in a group of normal-weight and obese individuals. Fat distribution was assessed with abdominal computed tomography (CT) scanning, determining subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Selected POPs (28 polychlorinated biphenyls [PCBs] and the pesticide p,p’-dichlorodiphenyldichloroethylene [p,p’-DDE]) were measured in serum. In a subset of obese individuals undergoing bariatric surgery, POPs were also measured in adipose tissue. RESULTS Among obese participants, serum and adipose tissue levels of POPs were significantly correlated to glucose levels during an oral glucose tolerance test. Logistic regression using a model including age, age2, sex, family history of diabetes, BMI, CT-VAT, smoking behavior, physical activity level score, and a POP level identified serum levels of PCB153, the sum of PCBs and p,p’-DDE as significant predictors of abnormal glucose tolerance (odds ratio 4.6, 4.8, and 3.4, respectively; P < 0.05). Adipose tissue levels of p,p’-DDE were also significant predictors (odds ratio 81.6; P < 0.05). Serum levels of PCBs were inversely related to BMI, while serum and adipose tissue levels of all POPs were positively related to the CT-VAT/SAT ratio, suggesting an important role for the visceral fat compartment in POP dynamics. CONCLUSIONS Our findings further sustain the theory that exposure to environmentally relevant levels of POPs may exert both a diabetogenic and obesogenic effect.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Pop Levelsmentioning

confidence: 97%

See 1 more Smart Citation

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Visceral and subcutaneous adipose tissues (vAT and scAT) display different metabolic properties, the first being a highly metabolically active tissue and apparently more susceptible to lipolysis (Freedland, 2004;Preis et al, 2010). Despite these differences, their putative dissimilar POPs storage capability and subsequent implications are still under discussion as duly raised by La Merrill et al (2013) and other recent studies, however still with some restraints and insufficient to conclude this discussion (Malarvannan et al, 2013;Kim et al, 2014). This study aimed to answer some of this issues, evaluating in a sample of Portuguese obese patients undergoing bariatric surgery, the levels of POPs in AT depots as well as their possible association with MetS comorbidities before surgery.…”

Section: Chemicals and Reagentsmentioning

confidence: 94%

“…Despite the accepted different metabolic properties of vAT and scAT (Freedland, 2004;Alessi et al, 1997), their storage propensity for these compounds was still not fully explored. Several studies admit that the distribution was similar in the two AT, offering the possibility of extrapolation from only one of the tissues (Kim et al, 2011;Arrebola et al, 2010 importance of a comprehensive evaluation of the heterogeneity of POPs distribution (La Merrill et al, 2013), however the current studies are still insufficient mostly due to the normal methodological restraints posed by this type of research (Malarvannan et al, 2013;Kim et al, 2014). The knowledge that the distribution of POPs is different between vAT and scAT highlights the importance of being cautious when making extrapolations, but also that we could be missing distinct metabolic effects.…”

Section: Discussionmentioning

confidence: 99%

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

Pestana

Faria

Sá

et al. 2014

Environmental Research

View full text Add to dashboard Cite

A B S T R A C TBackground: The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects on human health. Objectives: To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) adipose tissue in a sample of Portuguese obese patients that underwent bariatric surgery, and assess their putative association with metabolic disruption preoperatively, as well as with subsequent body mass index (BMI) reduction. Methods: AT samples (n¼ 189) from obese patients (BMI Z35) were collected and the levels of 13 POPs were determined by gas chromatography with electroncapture detection (GC-ECD). Anthropometric and biochem-ical data were collected at the time of surgery. BMI variation was evaluated after 12 months and adipocyte size was measured in AT samples. Results: Our data confirm that POPs are pervasive in this obese population (96.3% of detection on both tissues), their abundance increasing with age (RS ¼ 0.310, po0.01) and duration of obesity (RS ¼ 0.170, po0.05). We observed a difference in AT depot POPs storage capability, with higher levels of ΣPOPs in vAT (213.97204.2 compared to 155.17147.4 ng/g of fat, po0.001), extremely relevant when evaluating their metabolic impact. Furthermore, there was a positive correlation between POP levels and the presence of metabolic syndrome components, namely dysglycaemia and hypertension, and more importantly with cardiovascular risk (RS ¼ 0.277, po0.01), with relevance for vAT (RS ¼ 0.315, po0.01). Finally, we observed an interesting relation of higher POP levels with lower weight loss in older patients. Conclusion: Our sample of obese subjects allowed us to highlight the importance of POPs stored in AT on the development of metabolic dysfunction in a context of obesity, shifting the focus to their metabolic effects and not only for their recognition as environmental obesogens.

show abstract

The Mitochondrial Exposome

Walker

Pennell

Jones

2018

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

View full text Add to dashboard Cite

Distribution of persistent organic pollutants in two different fat compartments from obese individuals

Cited by 73 publications

References 56 publications

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

The Mitochondrial Exposome

Contact Info

Product

Resources

About