Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

Aoyama, Shogo; Kim, Hyeon Ki; Hirooka, Rina; Tanaka, Mizuho; Shimoda, Takeru; Chijiki, Hanako; Kojima, Shuichi; Sasaki, Keisuke; Takahashi, Kengo; Makino, Saneyuki; Takizawa, Masahiro; Takahashi, Masaki; Tahara, Yu; Shimba, Shigeki; Shinohara, Kazuyuki; Shibata, Shigenobu

doi:10.1016/j.celrep.2021.109336

Cited by 37 publications

(33 citation statements)

References 78 publications

(86 reference statements)

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“…In the early active phase, protein intake, especially BCAA supplementation, promotes skeletal muscle hypertrophy in a muscle-clock-reliable manner. 312 Although the results thus far have been unpromising in clinical trials, a multitude of investigations into how the rhythm and pattern of diets influence human health are needed.…”

Section: Dietary Intervention In Tissue Health and Diseasementioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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Section: Dietary Intervention In Tissue Health and Diseasementioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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“…However, it is also clear from Section 4 and Figure 7 that many proteins, even those with DIAAS values < 100, contain one or more IAAs in digestible form at concentrations above the requirements. While this latter parameter is not typically included in protein quality metrics, it is key to consider in a dietary perspective because human protein consumption is mostly based on a mixture of different foods in meals throughout the day, and thus often a mixture of different proteins within a meal [ 127 ].…”

Section: Complementarity Of Different Protein Sourcesmentioning

confidence: 99%

Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications

et al. 2022

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For design of healthy and sustainable diets and food systems, it is important to consider not only the quantity but also the quality of nutrients. This is particularly important for proteins, given the large variability in amino acid composition and digestibility between dietary proteins. This article reviews measurements and metrics in relation to protein quality, but also their application. Protein quality methods based on concentrations and digestibility of individual amino acids are preferred, because they do not only allow ranking of proteins, but also assessment of complementarity of protein sources, although this should be considered only at a meal level and not a diet level. Measurements based on ileal digestibility are preferred over those on faecal digestibility to overcome the risk of overestimation of protein quality. Integration of protein quality on a dietary level should also be done based on measurements on an individual amino acid basis. Effects of processing, which is applied to all foods, should be considered as it can also affect protein quality through effects on digestibility and amino acid modification. Overall, protein quality data are crucial for integration into healthy and sustainable diets, but care is needed in data selection, interpretation and integration.

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“…The beneficial effect of proteins on blood pressure is small, according to previous studies (48). However, a high-protein breakfast has been suggested to accelerate overloading-induced skeletal muscle hypertrophy in mice and have greater skeletal muscle volume in human studies (49). It has also been revealed that breakfast and lunch proteins have a strong positive association with daily physical activity (unpublished observation), and recent studies have supported the role of physical activity in the prevention of hypertension (50).…”

Section: Discussionmentioning

confidence: 99%

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

et al. 2022

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Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, and one of the most significant risk factors for CVDs is high blood pressure. Blood pressure is associated with various nutrients, such as sodium, potassium, and cholesterol. However, research focusing on the timing of intake of these nutrients and blood pressure has not been conducted. In this study, we used dietary data and a questionnaire asking about the sleep, physical activity, and blood pressure, collected from the food-log app “Asken” (total N = 2,402), to investigate the relationship between the dietary data of nutrient intake in the breakfast, lunch, and dinner and blood pressure. Daily total intake of various nutrients such as sodium, sodium-to-potassium ratio, total energy, lipid, carbohydrate, and saturated fat showed a significant association with blood pressure depending on the meal timing. From multiple regression analysis, eliminating the confounding factors, lunch sodium-to-potassium ratio, dinner energy, lipid, cholesterol, saturated fat, and alcohol intake were positively associated with blood pressure, whereas breakfast protein and lunch fiber intake showed a negative association with blood pressure. Our results suggest that nutrient intake timing is also an important factor in the prevention of high blood pressure. Our study provides possibilities to prevent hypertension by changing the timing of nutrient intake, especially sodium, together with potassium and lipids. However, because our research was limited to food-log app users, broader research regarding the general population needs to be conducted.

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Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

Cited by 37 publications

References 78 publications

Dietary regulation in health and disease

Dietary regulation in health and disease

Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

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