Distribution of cell surface charges on mesothelium and lymphatic endothelium

Leak, Lee V.

doi:10.1016/0026-2862(86)90003-8

Cited by 53 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another interesting aspect of our findings is the pres ence of negatively charged coated pits and coated vesi cles at the mesothelial cell surface in the 3 examined peritoneal portions, thus confirming, Leak's [11] observa tions on mouse diaphragmatic peritoneum made with the help of cationic ferritin as a tracer. Pinocytotic vesicles and transcellular channels did not bind RR.…”

Section: Discussionsupporting

confidence: 75%

Ruthenium-Red-Stained Anionic Charges of Rat and Mice Mesothelial Cells and Basal Lamina: The Peritoneum Is a Negatively Charged Dialyzing Membrane

Gotloib

Shostack²,

Jaichenko³

1988

Nephron

View full text Add to dashboard Cite

The peritoneum has been classically considered to be an inert passive membrane. Previous studies demonstrated the presence of fixed anionic charges at the level of the peritoneal microvasculature and the subserosal interstitium. The present study describes the selective distribution of fixed anionic charges in the mesothelial cell plasmalemma and organelles as well as in the submesothelial basal lamina of rat and mice visceral, parietal and diaphragmatic peritoneum. These data support the idea that the peritoneum should be considered a negatively charged biological dialyzing membrane with selective capabilities. Therefore, transperitoneal transfer of charged solutes cannot be analyzed just on the basis of their molecular weight, size and shape.

show abstract

Section: Discussionsupporting

confidence: 75%

Ruthenium-Red-Stained Anionic Charges of Rat and Mice Mesothelial Cells and Basal Lamina: The Peritoneum Is a Negatively Charged Dialyzing Membrane

Gotloib

Shostack²,

Jaichenko³

1988

Nephron

View full text Add to dashboard Cite

show abstract

“…The potassium͞chloride cotransporter KCC1 for example, plays an important role in the control of extracellular fluid volume as well as in the control of membrane potential (44). Lymphatic endothelium is characterized by a high density of anionic sites on cell membranes, particularly along intercellular junctions, which have been suggested to facilitate movement of small solutes and molecules into the lymphatic lumen (45). Hence, the expression of specific ion transporters in lymphatic endothelium may directly or indirectly regulate transport of solutes and fluid into the vessel.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of lymphatic endothelial cells

Podgrabinska

Braun²,

Velasco³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

420

353

View full text Add to dashboard Cite

show abstract

“…16 Moreover, within the interstitial space the charges, exclusive of the capillary basement membrane, are predominantly negative, so that negatively charged proteins are likely to be repelled from interstitial structures with enhancement of their movement into lymph. 12 17 Histological appearances also suggest that the alveolar basement membrane is a more important physiological barrier than the capillary basement membrane, in which case the use of cationic molecules might promote alveolar flooding.…”

Section: Anatomy and Physiologymentioning

confidence: 99%