Molecular characterization of lymphatic endothelial cells

Abstract

was inadvertently switched during the revision process with a previously published figure (1) showing results on B16 melanoma cells. The correct figure, summarizing the results on human MeWO melanoma cells transfected with ␣1,3-fucosyltransferase (FTIII), appears below. We apologize for any confusion caused by this mistake.

Lymphangiogenesis by blind‐ended vessel sprouting is concurrent with hemangiogenesis by vascular splitting

“…The expression of VEGFR-2 by lymphatic vessels has not been widely reported. However, molecular profiling demonstrated that lymphatic endothelial cells can express VEGR-2 (Podgrabinska et al, 2002).…”

Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy

“…Both growth factors promote angiogenesis in in vitro assays (Joukov et al, 1996;Joukov et al, 1997;Marconcini et al, 1999). Vascular endothelial growth factor-C promotes the formation of capillary-tube structures by lymphatic endothelial cells, but not blood vascular endothelial cells, in a collagen sandwich assay (Podgrabinska et al, 2002).…”

“…The recent discovery of specific lymphatic vessel markers, such as the hyaluronan receptor LYVE-1, podoplanin and Prox-1, new antibodies to these markers and antibody combinations has aided the identification of lymphatic vessels in histological specimens (Stacker et al, 2002) (Table 1). The exploitation of the differential expression of these new specific cell surface markers by lymphatic and blood vascular endothelial cells has allowed the separation of stable lymphatic cell populations for study (Podgrabinska et al, 2002). Animal models have been adapted from angiogenesis research and specific tumour, transgenic and knock-out models developed.…”

D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma

“…It is also known that none of the previously studied lymphatic markers (VEGFR-3, podoplanin, homeobox gene product Prox-1, hyaluronan receptor LYVE-1) are specific for lymphatic vasculature. 27 Although some markers are fairly specific for lymphothelium, they exhibit different expression patterns during prenatal development and the respective immunopositivity does not necessarily indicate the lymphothelial origin of a vascular tumor. For example, VEGFR-3 selectively stains normal lymphatics in adult tissues; 28,29 however, it is expressed in both lymphatic and blood vessels in the early embryonal period.…”