Distribution of antibiotic resistance genes in the environment

Zhuang, Mei; Achmon, Yigal; Cao, Yuping; Liang, Xiaomin; Chen, Liang; Wang, Hui; Siame, Bupe A.; Leung, Ka Yin

doi:10.1016/j.envpol.2021.117402

Cited by 175 publications

(85 citation statements)

References 148 publications

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“…The main research has been conducted in the medical/clinical field and has linked the spread of AMR to antimicrobial misuse and overuse as a major factor in the maintenance of AMR. In contrast, the natural variability of resistance genes (RGs), mobile genetic elements (MGEs) and the frequency of their transmission in different types of natural environments are not sufficiently studied ( Zhuang et al, 2021 ). A recent survey of AMR-related research funding showed that only 3% of projects involved research at the environmental scale ( Singer et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics

et al. 2022

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Continuous exposure to low concentrations of antibiotics (sub-minimal inhibitory concentration: sub-MIC) is thought to lead to the development of antimicrobial resistance (AMR) in the environmental microbiota. However, the relationship between antibiotic exposure and resistance selection in environmental bacterial communities is still poorly understood and unproven. Therefore, we measured the concentration of twenty antibiotics, resistome quality, and analyzed the taxonomic composition of microorganisms in river biofilms collected upstream (UPS) and downstream (DWS) (at the point of discharge) from the wastewater treatment plant (WWTP) of Poitiers (France). The results of statistical analysis showed that the antibiotic content, resistome, and microbiome composition in biofilms collected UPS were statistically different from that collected DWS. According to Procrustes analysis, microbial community composition and antibiotics content may be determinants of antibiotic resistance genes (ARGs) composition in samples collected DWS. However, network analysis showed that the occurrence and concentration of antibiotics measured in biofilms did not correlate with the occurrence and abundance of antibiotic resistance genes and mobile genetic elements. In addition, network analysis suggested patterns of co-occurrence between several ARGs and three classes of bacteria/algae: Bacteroidetes incertae sedis, Cyanobacteria/Chloroplast, and Nitrospira, in biofilm collected UPS. The absence of a direct effect of antibiotics on the selection of resistance genes in the collected samples suggests that the emergence of antibiotic resistance is probably not only due to the presence of antibiotics but is a more complex process involving the cumulative effect of the interaction between the bacterial communities (biotic) and the abiotic matrix. Nevertheless, this study confirms that WWTP is an important reservoir of various ARGs, and additional efforts and legislation with clearly defined concentration limits for antibiotics and resistance determinants in WWTP effluents are needed to prevent their spread and persistence in the environment.

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Section: Introductionmentioning

confidence: 99%

River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics

et al. 2022

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“…Also, a high level of tetracycline, multidrug, and erythromycin ARGs are shared by swine, poultry, and human feces ( 18 ). The tight connections among humans, animals, and environment urge us to study the resistome from the One Health perspective ( 19 ). Investigation into each compartment can reflect its contribution to the overall evolution of the resistome.…”

Section: Introductionmentioning

confidence: 99%

Burkholderiaceae and Multidrug Resistance Genes Are Key Players in Resistome Development in a Germfree Soil Model

et al. 2021

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“…Soil [79], sewage [80], and even air dust [81] may be important reservoirs involved in the spread of ARG. This suggests that the environment is a huge reservoir involved in the spread of ARG [82].…”

Section: Discussionmentioning

confidence: 99%

Metagenomics-Based Analysis of the Age-Related Cumulative Effect of Antibiotic Resistance Genes in Gut Microbiota

Xie

Liu

et al. 2021

Antibiotics

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Antibiotic resistance in bacteria has become a major global health problem. One of the main reservoirs of antibiotic resistance genes is the human gut microbiota. To characterise these genes, a metagenomic approach was used. In this study, a comprehensive antibiotic resistome catalog was established using fecal samples from 246 healthy individuals from world’s longevity township in Jiaoling, China. In total, 606 antibiotic resistance genes were detected. Our results indicated that antibiotic resistance genes in the human gut microbiota accumulate and become more complex with age as older groups harbour the highest abundance of these genes. Tetracycline resistance gene type tetQ was the most abundant group of antibiotic resistance genes in gut microbiota, and the main carrier of antibiotic resistance genes was Bacteroides. Antibiotic efflux, inactivation, and target alteration were found to be the dominant antimicrobial resistance mechanisms. This research may help to establish a comprehensive antibiotic resistance catalog that includes extremely long-lived healthy people such as centenarians, and may provide potential recommendations for controlling the use of antibiotics.

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Distribution of antibiotic resistance genes in the environment

Cited by 175 publications

References 148 publications

River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics

River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics

Burkholderiaceae and Multidrug Resistance Genes Are Key Players in Resistome Development in a Germfree Soil Model

Metagenomics-Based Analysis of the Age-Related Cumulative Effect of Antibiotic Resistance Genes in Gut Microbiota

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