Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

Biegański, Tadeusz; Kusche, Jürgen; Lorenz, W.; Hesterberg, R.; Stahlknecht, C. D.; Feussner, Klaus D.

doi:10.1016/0304-4165(83)90092-2

Cited by 132 publications

(94 citation statements)

References 29 publications

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“…These include (i) prevention of the expression of cyclo-oxygenase (COX II) caused by endotoxin (Masferrer et al, 1992) or LTA , (ii) prevention of the generation of platelet-activating factor (PAF; Parente & Flower, 1985), (iii) attenuation of the formation of TNFa (Beutler et al, 1986;Flower, 1988; this study), (iv) prevention of the expression of adhesion molecules as well as activation of neutrophils (Cronstein et al, 1992). In addition to inhibiting iNOS activity, aminoguanidine also inhibits polyamine catabolism (Seiler et al, 1985), catalase activity (Ou & Wolff, 1993), histamine metabolism (Bieganski et al, 1983) as well as the formation of glycosylation end products (Brownlee et al, 1988;Edelstein & Brownlee, 1992). Our finding that pretreatment of rats with aminoguanidine prevents the LTA + PepG induced expression of iNOS protein and activity (lung), without affecting TNFa production, highlights the fact that aminoguanidine exerts non-specific effects which are unrelated to inhibition of iNOS activity.…”

Section: Experimental Protocolmentioning

confidence: 73%

Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram‐positive shock

Kengatharan

Kimpe

Thiemermann

1996

British J Pharmacology

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1 The pathological features of Gram-positive shock can be mimicked by the co-administration of two cell wall components of Staphylococcus aureus, namely lipoteichoic acid (LTA) and peptidoglycan (PepG). This is associated with the expression of the inducible isoform of nitric oxide synthase (iNOS) in various organs. We have investigated the effects of dexamethasone (which prevents the expression of iNOS protein) or aminoguanidine (an inhibitor of iNOS activity) on haemodynamics, multiple organ dysfunction syndrome (MODS) as well as iNOS activity elicited by LTA+PepG in anaesthetized rats. 2 Co-administration of LTA (3 mg kg-', i.v.) and PepG (10 mg kg-', i.v.) resulted in a significant increase in the plasma levels of tumour necrosis factor-a (TNFa, maximum at 90 min) as well as a biphasic fall in mean arterial blood pressure (MAP) from 120 + 3 mmHg (time 0) to 77 + 5 mmHg (at 6 h, n = 8; P< 0.05). This hypotension was associated with a significant tachycardia (4-6 h, P <0.05) and a reduction of the pressor response elicited by noradrenaline (NA, 1 mg kg-', i.v., at 1-6 h; n =8, P < 0.05). Furthermore, LTA + PepG caused time-dependent increases in the serum levels of markers of hepatocellular injury, glutamate-pyruvate-transaminase (GPT) and glutamate-oxalacetate-transaminase (GOT). In addition, urea and creatinine (indicators of renal dysfunction) were increased. There was also a fall in arterial oxygen tension (Pao2), indicating respiratory dysfunction, and metabolic acidosis as shown by the significant drop in pH, Paco2 and HCO3-. These effects caused by LTA + PepG were associated with the induction of iNOS activity in aorta, liver, kidney and lungs as well as increases in serum levels of nitrite + nitrate (total nitrite). 3 Pretreatment of rats with dexamethasone (3 mg kg-', i.p.) at 120 min before LTA + PepG administration significantly attenuated these adverse effects as well as the increases in the plasma levels of TNFa caused by LTA + PepG. The protective effects of dexamethasone were associated with a prevention of the increase in iNOS activity (in aorta, liver, lung, kidney), the expression of iNOS protein (in lungs), as well as in the increase in the plasma levels of total nitrite. 4 Treatment of rats with aminoguanidine (5 mg kg-' + 10 mg kg-h-) starting at 120 min after LTA + PepG attenuated most of the adverse effects and gave a significant inhibition of iNOS activity (in various organs) as well as an inhibition of the increase in total plasma nitrite. However, aminoguanidine did not improve renal function although this agent caused a substantial inhibition of NOS activity in the kidney. 5 Thus, an enhanced formation of NO by iNOS importantly contributes to the circulatory failure, hepatocellular injury, respiratory dysfunction and the metabolic acidosis, but not the renal failure, caused by LTA + PepG in the anaesthetized rat.

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Section: Experimental Protocolmentioning

confidence: 73%

Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram‐positive shock

Kengatharan

Kimpe

Thiemermann

1996

British J Pharmacology

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“…Wäh rend der über Nacht bei Raum tem pe ra tur (18 -26 °C) statt fin den den In ku ba ti on wur de das His ta min durch die in der Pro be vor han de ne DAO ab ge baut. Im nächs ten [20]. Das Serum al ler Pa tien ten wur de 2-mal ana ly siert.…”

Section: Methodeunclassified

“…Es wur den schon vie le Stu dien zum Thema His ta mi nin to le ranz und Kor re la ti on zu einer re du zier ten DAO-Ak ti vi tät ver öf fent licht [15,18,20,21]. Die Di ag no se HIT wird norma ler wei se ge stellt, wenn ty pi sche HITSymptome auf tre ten, die sich nach ei ner hista min frei en Diät bes sern [22].…”

Section: Diskussionunclassified

Histaminintoleranz: Wie sinnvoll ist die Bestimmung der Diaminoxidase-Aktivität im Serum in der alltäglichen klinischen Praxis?

Töndury¹,

Wüthrich²,

Schmid‐Grendelmeier³

et al. 2008

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(2008)His ta mi nin to le ranz: Wie sinn voll ist die Be stim mung der Di amin oxi da se-Ak tivi tät im Se rum in der all tägli chen kli nischen Praxis?Hin ter grund: Eine Nah rungs mit tel un verträg lich keit kann durch ei nen ver min der ten en zy ma ti schen His ta min ab bau auf grund einer ver rin ger ten Ak ti vi tät der Di amin oxi da se (DAO) in du ziert sein (His ta mi nin to le ranz (HIT)). Ziel set zung: Ziel der vor lie gen den Stu die war es he raus zu fin den, ob die DAOAktivität im Se rum bei Pa tien ten, de ren Vorge schich te eine HIT ver mu ten lässt, im Vergleich zu Pa tien ten ohne eine Vor ge schich te mit HIT sig ni fi kant ver rin gert ist. Me tho den: Un ter sucht wur den 61 Pa tien ten und 20 Kontrol len. Bei 26 Pa tien ten (schwere HIT) lag eine Vor ge schich te mit min de stens zwei ty pischen HIT-Symp to men in Zu sam men hang mit der Auf nah me von min de stens zwei his tamin rei chen Nah rungs mit teln vor. Bei 35 Patien ten (mä ßi ge HIT) war nach der Auf nah me von min de stens ei nem his ta min rei chen Nahrungs mit tel min de stens ein HIT-Symp tom auf ge tre ten. Die 20 ge sun den Kon trol len zeig ten kei ner lei HIT-Symp to me. Die Pa tienten wur den zur Art der kli ni schen Symp to me und zum Zu sam men hang der Symp to me mit der Auf nah me der Nah rungs mit tel be fragt. Die DAO-Aktivität im Se rum wur de mit tels ELI SA ana ly siert. Er geb nis se: Es konn ten kei ne Un ter schie de be züg lich der DAO-Konzen tra ti on im Se rum zwi schen den Grup pen fest ge stellt wer den. Schluss fol ge rung: Ba sierend auf der Ana mne se mit al ler gie ähn li chen Symp to men nach Auf nah me von histaminreichen Nah rungs mit teln bie tet die Bestim mung der DAO-Ak ti vi tät im Se rum in der all täg li chen kli ni schen Pra xis kei ne Hilfe stel lung für die Di ag no se ei ner HIT.His ta mine in tol er ance: Is the de ter mina tion of diamine oxidase ac tiv ity in the serum use ful in rou tine clin i cal prac tice?Back ground: An in tol er ance to food might be in duced by an im paired en zy matic his ta mine deg ra da tion due to a de fi ciency of diamine oxidase (DAO) ac tiv ity (His ta mine in tol er ance [HIT]). Ob jec tive: The aim of the study was to in ves ti gate if pa tients his to ries, that are sug ges tive to HIT have a sig nif i cant re duced se rum DAO ac tiv ity com pared to patients with out his tory of HIT. Meth ods: 61 patients and 20 con trols were stud ied. 26 patients (strong HIT) had a his tory of at least two typ i cal symp toms of HIT with re la tion to the in take of at least two his ta mine rich foods. 35 pa tients (mod er ate HIT) had a his tory of at least one symp tom af ter the in take of at least one his ta mine rich food (but not both). 20 healthy vol un teers (con trol) did not have any symp toms of HIT. Pa tients were in ter viewed on type of clin i cal symp toms and the re la tion of symp toms to food in ges tion. Sera were ana lysed for DAO ac tiv ity by an ELISA test. Re sults: No dif fer ence of se rum DAO lev els could be found be tween groups o...

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“…Diamine oxidase D i a m i n e ox i d a s e ( DAO ) , a c y t o p l a s m i c e n z y m e found in almost all organs is present in a particularly high concentration in the epithelial cells of the small intestine [44][45][46] . Following injury to intestinal epithelial cells DAO is released into the intestinal lumen and intercellular space where it is taken up by lymphatics and blood vessels [45] .…”

Section: Mucosal Transport and Barrier Functionmentioning

confidence: 99%

Biomarkers for radiation-induced small bowel epithelial damage: An emerging role for plasma Citrulline

Lutgens¹,

Lambin²

2007

WJG

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Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specific objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail.

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Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

Cited by 132 publications

References 29 publications

Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram‐positive shock

Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram‐positive shock

Histaminintoleranz: Wie sinnvoll ist die Bestimmung der Diaminoxidase-Aktivität im Serum in der alltäglichen klinischen Praxis?

Biomarkers for radiation-induced small bowel epithelial damage: An emerging role for plasma Citrulline

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