Distress, Fatigue, and Sexuality: Understanding and Treating Concerns and Symptoms in Patients With Multiple Myeloma

Catamero, Donna; Noonan, Kimberly; Richards, Tiffany; Faiman, Beth; Manchulenko, Cindy; Devine, H.; Bertolotti, P; Gleason, Charise; Board, and

doi:10.1188/17.cjon.s5.7-18

Cited by 10 publications

(9 citation statements)

References 70 publications

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“…For rating of neuropathy only question 43 of the QLQ MY-20 was used, which is less informative than a neuropathy-specific questionnaire and has not been validated as such. Also, one should keep in mind that the EORTC instruments do not specifically capture satisfaction with sexual function, an item which is of importance to a proportion of patients with excellent control of their disease [31,32]. Furthermore, other instruments such as the FACT-MM PRO [33] or the FACT-G could have been used, but we selected the EORTC QLQ C30 and QOL-MY20 questionnaire for this study as the latter tools have uniformly been used in all of the recent MM trials [9,12,13,28,29,23] with QoL assessments, a fact which facilitates comparison of results.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population

Ludwig

Pönisch

Knop

et al. 2019

Leukemia & Lymphoma

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Section: Discussionmentioning

confidence: 99%

Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population

Ludwig

Pönisch

Knop

et al. 2019

Leukemia & Lymphoma

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“…Only one qualitative study acknowledges the existence of sexuality concerns among MM survivors but does not expand upon them 3 . Hematological cancer treatment is known to impact sexual function, and people with MM are also likely to experience sexual concerns 2,4 .…”

Section: Introductionmentioning

confidence: 99%

Patient reported disease-specific concerns relating to sexuality in multiple myeloma

Henkelman

Toivonen

Tay

et al. 2022

Preprint

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Purpose There is increasing recognition that cancer and its treatment can have lasting effects on sexuality. However, most studies focus on breast and reproductive cancers while hematological cancers remain understudied. Only one prior study has acknowledged the existence of sexuality concerns among multiple myeloma (MM) survivors but did not expand upon them. This study explored how diagnosis and treatment of MM may affect sexual expression and also examined patient-provider communication about sexuality. Methods Men and women with MM (N=65) were recruited internationally for an online survey. The survey included open-ended questions about MM-specific barriers to engaging in sexual activity, methods used to adapt to sexual changes, and communication with healthcare providers. Answers to open-ended questions were summarized using a qualitative descriptive approach. Results Participants identified several barriers to sexual activity that may be unique to MM, such as concerns about bone health, infections, and vaginal bleeding and bruising. They also described adapting to sexual challenges by trying sexual medicines/aids, changing their sexual expression, and managing treatment risks. Half of the participants reported speaking to providers about sexuality, with a minority receiving sexual health-related recommendations. Conclusions Participants often faced sexual challenges after diagnosis, many of which may be unique to MM. While some were able to adapt to these changes, sexuality concerns were under-discussed and under-treated by healthcare providers. Proposed suggestions for improving patient-provider communication about sexuality and clinical care are offered based on the gaps identified by participants.

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“…The major symptoms of MM include osteolytic lesions, bone pain, pathological fractures, and hypercalcemia. [3][4][5][6] Traditionally, the mechanism of MM has been believed that myeloma cells secrete inhibitory factors, resulting in bone destruction and osteogenesis inhibition. Cytogenetic studies of MM suggest that the malignant transformation is the result of a multigene interaction with the environment.…”

Section: Introductionmentioning

confidence: 99%

“…The average survival time of MM is 3 to 4 years and most patients end up with recurrence. The major symptoms of MM include osteolytic lesions, bone pain, pathological fractures, and hypercalcemia . Traditionally, the mechanism of MM has been believed that myeloma cells secrete inhibitory factors, resulting in bone destruction and osteogenesis inhibition.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor gene polymorphism is associated with multiple myeloma

Rui

Liu

Lin

et al. 2019

J of Cellular Biochemistry

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Objectives The aim of this study was to explore the Vitamin D receptor (VDR) gene polymorphism and its association with multiple myeloma (MM) development. Methods The peripheral blood of 40 MM cases and 84 healthy controls were collected. Polymerase chain reaction (PCR) and DNA sequencing were applied to detect VDR gene polymorphism (including: FokI, BsmI, ApaI, and TaqI). SHESIS biological information software was used to analyze genotypes, alleles, linkage disequilibrium (LD), haplotype distribution, and their association with MM. Results Compared with controls, the MM group had a significantly higher frequency of the A allele in BsmI site (8.7% vs 2.4%) and C allele in the TaqI site (10.5% vs 3.6%). These two alleles were closely associated with an increased risk of MM (P = .025; P = .030). The highly rare genotypes (BsmI‐AA and TaqI‐CC) were found in one patient with MM. Conclusion VDR gene polymorphisms may be a molecular marker of MM risk.

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Distress, Fatigue, and Sexuality: Understanding and Treating Concerns and Symptoms in Patients With Multiple Myeloma

Abstract: Ongoing patient education and attention to medical and psychological care is important to assess and address patients' needs, such as cancer-related fatigue, sexual dysfunction, and distress.

Cited by 10 publications

References 70 publications

Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population

Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population

Patient reported disease-specific concerns relating to sexuality in multiple myeloma

Vitamin D receptor gene polymorphism is associated with multiple myeloma

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