Vitamin D receptor gene polymorphism is associated with multiple myeloma

Abstract

Objectives The aim of this study was to explore the Vitamin D receptor (VDR) gene polymorphism and its association with multiple myeloma (MM) development. Methods The peripheral blood of 40 MM cases and 84 healthy controls were collected. Polymerase chain reaction (PCR) and DNA sequencing were applied to detect VDR gene polymorphism (including: FokI, BsmI, ApaI, and TaqI). SHESIS biological information software was used to analyze genotypes, alleles, linkage disequilibrium (LD), haplotype distribution, and their association with MM. Results Compared with controls, the MM group had a significantly higher frequency of the A allele in BsmI site (8.7% vs 2.4%) and C allele in the TaqI site (10.5% vs 3.6%). These two alleles were closely associated with an increased risk of MM (P = .025; P = .030). The highly rare genotypes (BsmI‐AA and TaqI‐CC) were found in one patient with MM. Conclusion VDR gene polymorphisms may be a molecular marker of MM risk.

Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction

“…Further analysis revealed that amplification of 1q21 with 4 or more copies served as a prognostic factor for adverse events in MM and 1q21 gains even predicted a poor overall survival in patients receiving Bortezomib-based treatment regimens. Finally, Vitamin D receptor gene polymorphisms, TaqI (C allele) and BsmI (A allele) had higher frequency and increased risk of MM in Chinese MM patients ( n =40, ethnicity not known) [89] .…”

“… Russian 69 IL-6 CC genotype ( [81] 12. Chinese 67 CCND1 G870A (GG variant) [82] ) 129 MDR1 C1236T (CC genotype C3435T (CC genotype) [84] ) 827 NCOA1 HLA-I rs79480871 rs6457327 ( [86] 40 VDR TaqI (C allele) BsmI (A allele) [89] ) 13. Korean 196 MTHFR 677CC 1298CC [90] 117 NQO1 NQO1*2/*2 genotype [92] 14.…”

Integrative Hematology: State of the Art

“…Vitamin D: Even in the case of MM, there seems to be a relationship between this hormone and the probability of the onset of the disease: patients with MM have a greater deficiency of vitamin D and this deficiency appears “alarming” in patients with bone lesions [ 101 ]. Specific polymorphisms of the vitamin D receptor (VDR) gene are associated with MM and may be a molecular marker of risk [ 102 ].…”

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

“…VRD polymorphisms have been reported in MM cell lines with an increased risk stage. Specifically, single-nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and VDR (Fok1) have been reported in several studies [ 121 , 122 , 123 , 124 ]. These reports were confirmed by a different group of researchers, who studied plasmablastic lymphoma and myeloma cells more broadly [ 120 ].…”