Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy Chinese infants

Li, Na; Liang, Shengnan; Chen, Qingxue; Zhao, Lina; Li, Bailiang; Gui-cheng, Huo

doi:10.1016/j.jprot.2020.104071

Cited by 23 publications

(20 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies presented thus far support the consensus that microbial colonization of the infant occurs at birth and the establishment of replicating microbial cells does not commonly occur in healthy pregnancies, devoid of clinical infections [73] . This is in agreement with Walter and Horneff [74] , who highlighted that there is no overlap between the bacterial taxa detected in utero in the sequencing studies of the in utero environment, with evident conformity between the bacterial taxa identified in utero and the controls.…”

Section: In Utero Microbiome Transfersupporting

confidence: 91%

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

Dempsey¹,

Ryan²,

Ross³

et al. 2022

MRR

View full text Add to dashboard Cite

The human gut microbiome harbors a diverse range of microbes that play a fundamental role in the health and well-being of their host. The early-life microbiome has a major influence on human development and long-term health. Perinatal factors such as maternal nutrition, antibiotic use, gestational age and mode of delivery influence the initial colonization, development, and function of the neonatal gut microbiome. The perturbed early-life gut microbiome predisposes infants to diseases in early and later life. Understanding how perinatal factors guide and shape the composition of the early-life microbiome is essential to improving infant health. The following review provides a synopsis of perinatal factors with the most decisive influences on initial microbial colonization of the infant gut.

show abstract

Section: In Utero Microbiome Transfersupporting

confidence: 91%

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

Dempsey¹,

Ryan²,

Ross³

et al. 2022

MRR

View full text Add to dashboard Cite

show abstract

“…Fewer studies have addressed differences in infant fecal metabolomic profiles according to delivery mode, but the study by Bazanella et al did not find differences by delivery mode groups. We observed elevated concentrations of maltose in Cesarean sectiondelivered infants compared with vaginally delivered infants in our study, a finding that was also made in a recent study of 60 Chinese infants [33]. It is difficult to speculate on the causal underpinnings of the differences in the concentration of the few metabolites found to be associated with delivery mode.…”

Section: Discussionsupporting

confidence: 55%

Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants

et al. 2021

View full text Add to dashboard Cite

Cesarean delivery and formula feeding have both been implicated as important factors associated with perturbations to the infant gut microbiome. To investigate the functional metabolic response of the infant gut microbial milieu to these factors, we profiled the stool metabolomes of 121 infants from a US pregnancy cohort study at approximately 6 weeks of life and evaluated associations with delivery mode and feeding method. Multivariate analysis of six-week stool metabolomic profiles indicated discrimination by both delivery mode and diet. For diet, exclusively breast-fed infants exhibited metabolomic profiles that were distinct from both exclusively formula-fed and combination-fed infants, which were relatively more similar to each other in metabolomic profile. We also identified individual metabolites that were important for differentiating delivery mode groups and feeding groups and metabolic pathways related to delivery mode and feeding type. We conclude based on previous work and this current study that the microbial communities colonizing the gastrointestinal tracts of infants are not only taxonomically, but also functionally distinct when compared according to delivery mode and feeding groups. Further, different sets of metabolites and metabolic pathways define delivery mode and diet metabotypes.

show abstract

“…Akkermansia muciniphila , a functionally important Gram-negative bacterium related to mucus degradation was enriched at V4 and V5, compared to the baseline ( Figure 6 ). A recent study has confirmed that Akkermansia muciniphila is able to utilize 2′-FL and other HMO [ 51 ], although this bacterium is more closely associated with complementary feeding [ 52 ]. Another important microbial species that was significantly enriched at V4 and V5 were butyrate-producing bacteria, including Faecalibacterium prausnitzii and Anaerostipes caccae [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow’s Milk Protein Allergy

et al. 2022

View full text Add to dashboard Cite

This open-label, non-randomized, multicenter trial (Registration: NCT 03661736) aimed to assess if an amino acid-based formula (AAF) supplemented with two human milk oligosaccharides (HMO) supports normal growth and is well tolerated in infants with a cow’s milk protein allergy (CMPA). Term infants aged 1–8 months with moderate-to-severe CMPA were enrolled. The study formula was an AAF supplemented with 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT). Infants were fed the study formula for 4 months and were offered to remain on the formula until 12 months of age. Tolerance and safety were assessed throughout the trial. Out of 32 infants (mean age 18.6 weeks; 20 (62.5%) male), 29 completed the trial. During the 4-month principal study period, the mean weight-for-age Z score (WAZ) increased from −0.31 at the baseline to +0.28 at the 4-months’ follow-up. Linear and head growth also progressed along the WHO child growth reference, with a similar small upward trend. The formula was well tolerated and had an excellent safety profile. When comparing the microbiome at the baseline to the subsequent visits, there was a significant on-treatment enrichment in HMO-utilizing bifidobacteria, which was associated with a significant increase in fecal short-chain fatty acids. In addition, we observed a significant reduction in the abundance of fecal Proteobacteria, suggesting that the HMO-supplemented study formula partially corrected the gut microbial dysbiosis in infants with CMPA.

show abstract

Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy Chinese infants

Cited by 23 publications

References 59 publications

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants

Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow’s Milk Protein Allergy

Contact Info

Product

Resources

About