Distention as a Factor in Intestinal Obstruction

Herrin, R. C.

doi:10.1001/archinte.1933.00150200155013

Cited by 48 publications

(6 citation statements)

References 24 publications

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“…Because the induced PD change is always in the direction of enhancing the negativity of the lumen, it must occur as a result of either enhanced anion secretion or cation absorption, or both. There is much evidence to show that increases in intestinal motility (Gregory, 1962;Cooke, 1967;Matuchansky et al, 1972), distension of the lumen (Herrin and Meek, 1933), administration of cholinergic agents (Florey et al, 1941), induction of nausea (Gregory, 1947), and stimulation of the vagus (Savitch and Sochestvensky, 1917;Wright et al, 1940) are all associated with increases in intestinal secretion. All these, except the latter, have been shown to increase the transjejunal PD.…”

Section: Discussionmentioning

confidence: 99%

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Read¹,

Smallwood²,

Levin³

et al. 1977

Gut

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SUMMARY Recordings of transmural potential difference (PD) across the jejunum of conscious man in situ are characterised by spontaneous fluctuations of up to 10 mV. In 25 of 31 subjects (comprising seven normal controls and 24 patients under investigation for malabsorption, six of whom had coeliac disease) we observed a clear association between these fluctuations and changes in intraluminal pressure recorded at the same site. The most frequent PD changes were associated with type III pressure waves. These consisted predominantly of large waves (3.1 + 0 1 mV; mean + SEM, n = 317) which reached maximal amplitude approximately 45 seconds after the pressure peak and had a duration of 120 + 3 s, but also included less frequent spikes (0 5 + 0.1 mV; n = 110) concurrent with the pressure wave with a duration of 5 + 1 s. Although by recording at two sites in the jejunum 10 cm apart we were able to demonstrate that the type III pressure waves appeared to be propagated aborally at a median rate of 60 cm per minute, the apparent rates of propagation of the corresponding PD waves were much more variable. The largest PD changes (7i8 + 0 4 mV; n = 19), lasting several minutes, were found in association with runs of type I waves (basic rhythm) superimposed on a type III wave. Both pressure and PD activities were suppressed by intramuscular propantheline bromide. Intraluminal pilocarpine caused a transient rise in PD not always accompanied by a change in pressure. Distension of the jejunum by rapid injection of a bolus of isotonic sodium chloride produced a delayed rise in the PD which could be prevented by prior administration of propantheline bromide. Experiments usingThiryVella loops of proximal jejunum in conscious dogs confirmed the effect of jejunal distension on the PD and also demonstrated that spontaneous retching is preceded by an increase in the PD.Consideration of these results in conjunction with data from other workers suggests the hypothesis that the larger spontaneous fluctuations in transmural PD in the jejunum of conscious man are caused by changes in electrogenic secretion associated with intestinal motility and mediated by cholinergic mechanisms. The possible association of increased secretory activity with motility may have functions of lubrication as well as diluting and mixing the chyme for easier digestion and absorption.Several studies have noted that recordings of trans-changes have been a major obstacle to the investigamural PD in the human jejunum in situ are unstable tion of enterocyte transfer processes by electrical (Fordtran et al., 1968;Wingate et al., 1973; Read et methods. Our observation that propantheline al., 1974), being characterised by irregular fluctua-bromide (Pro-Banthine) inhibits these fluctuations tions which can last for several minutes and attain (Read et al., 1974; indicated that they may be amplitudes of 10 mV. These apparently spontaneous related to intestinal motility, which is also inhibited by this drug. We have investigated this possibility by pressure at the same site i...

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Section: Discussionmentioning

confidence: 99%

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Read¹,

Smallwood²,

Levin³

et al. 1977

Gut

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“…frequently leads to intestinal distention from pooling of fluids and gases proximal to the obstruction (13). In 1933, Herrin and Meek (10) observed that distention of an intestinal loop by a water-filled balloon led to secretion of fluid into the lumen. Others have shown that obstruction of the intestine is followed by a decline in the net rate of water and electrolyte absorption from the lumen ( 12).…”

mentioning

confidence: 99%

Canine intestinal secretion during and after rapid distention of the small bowel

Caren¹,

Meyer²,

Grossman³

1974

American Journal of Physiology-Legacy Content

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“…Ischemia [27], intestinal distention [3. 12, 20, 22], increased intraluminal pressure [6,12,22], bacterial overgrowth [24,25] and leak age of toxic factors [20,24] have been sug gested as possible causes that are responsible for the abnormalities in transport of water and electrolytes. Fluid collection in the ob structed bowel can also be produced by dis turbances in absorption of amino acids or other nonelectrolytes.…”

Section: Discussionmentioning

confidence: 99%

Leucine Absorption after Mechanical Obstruction of the Rat Small Intestine

Hajjar¹,

Schwartz²,

Mirkin³

et al. 1982

Digestion

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Leucine absorption across the mechanically obstructed rat intestine was studied by in vivo and in vitro techniques. It varied between the early (after 2 h) and late (after 18 h) phases of the obstruction. During the early phase there was a reduction in mucosal uptake and in net absorption of the amino acid. At 18 h the inhibition in mucosal uptake was more prominent both above and below the occlusion site but net absorption was only reduced below the obstruction and was relatively unaffected above it. Mannitol and nonmediated leucine absorption were also increased above the obstruction. The findings during the late phase suggest the presence of an increase in leucine permeability across the intestine above the occlusion site. The observed normal rate of net leucine absorption across this segment is thought to be due to enhancement in intestinal diffusion which could be masking the depression in mucosal uptake.

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Distention as a Factor in Intestinal Obstruction

Cited by 48 publications

References 24 publications

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Canine intestinal secretion during and after rapid distention of the small bowel

Leucine Absorption after Mechanical Obstruction of the Rat Small Intestine

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