Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique

Abstract

In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin

“…The release of rosuvastatin from liquisolid tablets containing more than 2% w/w of Vivasol Õ and from all tablets with Kollidon Õ CL-F was faster in comparison to the results of conventional tablets introduced by Kapure et al 49 and Kamble et al 50 . According to Kapure et al 49 , the amount of drug released after 15 min from directly compressed conventional rosuvastatin tablets was about 15% (450 mL of buffer with pH 1.2 was used as a dissolution medium).…”

“…According to Kapure et al 49 , the amount of drug released after 15 min from directly compressed conventional rosuvastatin tablets was about 15% (450 mL of buffer with pH 1.2 was used as a dissolution medium). In the study performed by Kamble et al 50 , the percentage of rosuvastatin released after 15 min from conventional directly compressed tablets was about 20% (900 mL of buffer with pH 6.8 was used as a dissolution medium).…”

Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

“…A tablet was placed in each tube of the basket and the time for complete disintegration of the six tablets was recorded [20][21][22].…”

Formulation and Evaluation of Furosemide Liquisolid Compact

“…The disintegration apparatus with a basket rack assembly containing six open-ended tubes and 10-mesh screen on the bottom was used. A tablet was placed in each tube of the basket and the time for complete disintegration of the six tablets was recorded [21][22][23].…”