The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin

Vraníková, Barbora; Gajdziok, Jan; Doležel, Petr

doi:10.3109/10837450.2015.1089900

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…This cross-linking rendered it insoluble, highly hydrophilic, with excellent swelling properties and a unique fibrous nature. This gave the polymer excellent water wicking capabilities [21]. In addition, CCNa swelled rapidly in water without much gelling.…”

Section: Resultsmentioning

confidence: 95%

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A new design for a chronological release profile of etodolac from coated bilayer tablets: In-vitro and in-vivo assessment

Georgy

Farid

Latif

et al. 2019

Journal of Advanced Research

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Section: Resultsmentioning

confidence: 95%

“…In addition, CCNa swelled rapidly in water without much gelling. Thus, CCNa performed its disintegration role through the capillary action when it swelled and reduced the physical binding forces between particles [21].…”

Section: Resultsmentioning

confidence: 99%

A new design for a chronological release profile of etodolac from coated bilayer tablets: In-vitro and in-vivo assessment

Georgy

Farid

Latif

et al. 2019

Journal of Advanced Research

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“…This finding means that increasing X 2 level will lead to reduction in the disintegration time. Other studies have investigated the effect of Explotab on tablet disintegration times [43,47,48]. Both X 1 and X 3 have no significant effect on Y 2 .…”

Section: Resultsmentioning

confidence: 99%

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

et al. 2019

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Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing β-cyclodextrin (β-CD) and formulation of the inclusion complex as oral disintegrating tablets (ODTs). The solubility of the obtained complexes in various ratios has been studied. A Box–Behnken design (BBD) was utilized to investigate the influence of excipients on the quality of ODTs. The solubility of VRD was improved at 1:2 drug:β-CD ratio. The formulated VRD-ODTs exhibited satisfying results regarding the hardness and disintegration time. In addition, in vivo taste masking and disintegration time showed improved results, after placing the tablets in the oral cavity of the healthy volunteers. When compared with the marketed tablets, the pharmacokinetic parameters for the optimized VRD-ODTs exhibited a significant improvement with p < 0.05 in the maximum plasma concentration and reduction in the time needed to reach this concentration. Finally, the optimized VRD-ODTs exhibited increased oral absorption of VRD and subsequent decrease in the time of onset of clinical effect and masking the unpleasant taste.

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“…This increase in DT was more marked in formulas F3, F6 and less in F9. The reason behind this increase may be due to the formation of viscous gel layer on the surface of the tablet which prevents the penetration of water to the core of the tablet especially for super disintegrant CSS and SSG [30], as shown in fig. (3).…”

Section: Wetting Time (Wt) and In Vitro Disintegration Time (Dt)mentioning

confidence: 99%

Design Zolmitriptan Liquisolid Orodispersible Tablets and Their in Vitro Evaluation

Egla

Hammid

2016

Int J Pharm Pharm Sci

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Objective: The objective of present study is to develop orodispersible tablets (ODTs) of zolmitriptan by liquisolid technique using different types of super disintegrants to enhance the disintegration and dissolution of zolmitriptan to improve the bioavailability of the drug.Methods: Liquisolid ODTs of zolmitriptan were prepared from; microcrystalline cellulose (Avicel PH-102) as carrier, colloidal silicon dioxide (Aerosil 200) as a coating material, croscarmellose sodium (CSS), sodium starch glycolate (SSG), and crospovidone (CP) as super disintegrants, and propylene glycol as liquid vehicle. The ratio of carrier to coating material was kept constant in all formulations at 35:1, this ratio was chosen after testing the ratios 10:1, 15:1, 20:1, 25:1,30:1, and 35:1. The ratio 35:1 give optimal results relative to other ratios. The pre-compression evaluation includes: flow properties were measured using the angle of repose and the compressibility index and FT-IR. The prepared liquid-solid system compacts were evaluated for their post-compression evaluation which includes: hardness, friability, wetting time, in vitro disintegration time, drug content and in vitro drug release. Results:The tabletting properties of the liquid-solid ODTs were within the acceptable limits. Among the three super disintegrants, CP found to be the best in term of showing the fastest disintegration time. The optimized selected formula (F11) was prepared using 5% w/w crospovidone, by direct compression showed the shortest disintegration time (24 s), superior drug release profile [ the time required for 80% of the drug to be released (T80%) and percent drug dissolved in 2 min (D2 Conclusion:The overall results showed that CP was the best super disintegrant of showing the shortest disintegration time while loading factor of 0.125 was the best in the preparing of zolmitriptan liquid-solid ODTs, and this suggested the possibility of utilizing the selected best formula (F11) in the preparation of zolmitriptan ODTs as a new dosage form for oral administration. min) 1.84 min and 87.59%, respectively]. In addition to that, the selected formula had an acceptable hardness and friability, so it was selected as the best formula.

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The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin

Abstract: Kollidon® CL-F and Vivasol® in concentration ≥2.5% are suitable superdisintegrants for LSS with enhanced release of drug.

Cited by 12 publications

References 31 publications

A new design for a chronological release profile of etodolac from coated bilayer tablets: In-vitro and in-vivo assessment

A new design for a chronological release profile of etodolac from coated bilayer tablets: In-vitro and in-vivo assessment

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Design Zolmitriptan Liquisolid Orodispersible Tablets and Their in Vitro Evaluation

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