Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass

Houaoui, Amel; Lyyra, Inari; Agniel, Rémy; Pauthe, Emmanuel; Massera, Jonathan; Boissière, Michel

doi:10.1016/j.msec.2019.110340

Cited by 20 publications

(31 citation statements)

References 44 publications

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“…The molecular weight values of the PLA70 before and after processing and the processed composites are presented in Figure 1 . Processing the PLA70 into rods decreased its molecular weight by 56% (M n ) and 51% (M w ), which is similar compared to our earlier study [ 21 ].…”

Section: Resultssupporting

confidence: 89%

“…It was hypothesized that a less reactive glass would induce less degradation during processing. The molecular weight of PLA70 in the Si-BaG composites decreased by 71–77% (M n ) and 72–79% (M w ) during processing, which is less compared to the drop in M w with S53P4, but more compared to our previous study [ 21 ]. This high drop in molecular weight was not anticipated.…”

Section: Resultscontrasting

confidence: 70%

“…However, the composites showed superior bone formation capacity compared to the plain polymer, especially at later time points (26 and 52 weeks). Houaoui et al reported a faster decrease in the molecular weight of PLDLA in PLDLA/13-93 BaG composites during 10 weeks in Tris compared to PLDLA only [ 21 ]. Vergnol et al reported that adding 45S5 bioactive glass to PLDLA 70/30 increased the mass loss and water absorption of the composite and led to a faster decrease in molecular weight of PLDLA [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Glass Composition on Hydrolytic Degradation of Polylactide/Bioactive Glass Composites

et al. 2021

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Understanding the degradation of a composite material is crucial for tailoring its properties based on the foreseen application. In this study, poly-L,DL-lactide 70/30 (PLA70) was compounded with silicate or phosphate bioactive glass (Si-BaG and P-BaG, respectively). The composite processing was carried out without excessive thermal degradation of the polymer and resulted in porous composites with lower mechanical properties than PLA70. The loss in mechanical properties was associated with glass content rather than the glass composition. The degradation of the composites was studied for 40 weeks in Tris buffer solution Adding Si-BaG to PLA70 accelerated the polymer degradation in vitro more than adding P-BaG, despite the higher reactivity of the P-BaG. All the composites exhibited a decrease in mechanical properties and increased hydrophilicity during hydrolysis compared to the PLA70. Both glasses dissolved through the polymer matrix with a linear, predictable release rate of ions. Most of the P-BaG had dissolved before 20 weeks in vitro, while there was still Si-BaG left after 40 weeks. This study introduces new polymer/bioactive glass composites with tailorable mechanical properties and ion release for bone regeneration and fixation applications.

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Section: Resultssupporting

confidence: 89%

Section: Resultscontrasting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Impact of Glass Composition on Hydrolytic Degradation of Polylactide/Bioactive Glass Composites

et al. 2021

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“…The weight of the scaffolds was shown to increase during the incubation time, which might be related to the formation of the HAp layer on the surface of the samples; this is consistent with the results of previously-reported investigations on SBF-incubated scaffolds [49]. Moreover, the increased mass of the scaffolds could be the result of the water uptake by PCL, which was previously mentioned elsewhere [50].…”

Section: Weight Measurementssupporting

confidence: 91%

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

et al. 2020

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Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

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“…In this study, a B-BG was obtained from boron which completely replaced sodium. Studies from previous articles have confirmed its osteoinductive aptitude and degradation characteristics (Xia et al, 2019;Deilmann et al, 2020;Houaoui et al, 2020;Li et al, 2020). Also, implants that were hard to degrade were described to cause long-term inflammatory reactions, and stress shielding occurs, which results in bone resorption and implant loosening due to mechanical properties that do not match that of the natural bone (Fedorowicz et al, 2007;Xu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B2O3 (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO2. For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects.

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Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass

Cited by 20 publications

References 44 publications

Impact of Glass Composition on Hydrolytic Degradation of Polylactide/Bioactive Glass Composites

Impact of Glass Composition on Hydrolytic Degradation of Polylactide/Bioactive Glass Composites

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

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