Dissipative convective structures and nanoparticles encapsulation in Cu/alginate/dextran composite hydrogels and sponges

Khanam, Afroza; Parihar, Malkhan Singh; Bilgainya, Ruchi; Rai, Kavita; Khan, Farid

doi:10.1016/j.carbpol.2010.08.021

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…However, owing to weak mechanical performance, unstable thermal properties, and uncontrollable structure degradation, the practical application of neat alginate sponge is limited. To solve these problems, intensive research has been performed to prepare composite sponges based on alginate, such as the addition of chitosan, − dextran, − gelatin, collagen, , keratin, silk fibroin, , bacterial cellulose, starch, hydroxyapatite, calcium phosphate, and poly(ethylene glycol) . It is a pity that most of these works only emphasized the enhancement of the mechanical performance of sponges, but they realized it at the expense of biocompatibility (even adding an organic crosslinking agent).…”

Section: Introductionmentioning

confidence: 99%

TEMPO-Oxidized Nanocellulose Participating as Crosslinking Aid for Alginate-Based Sponges

Lin

Bruzzese

Dufresne

2012

ACS Appl. Mater. Interfaces

292

184

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Crosslinked polysaccharide sponges have been prepared by freeze-drying of amorphous alginate-oxidized nanocellulose in the presence of a Ca(2+) ionic crosslinking agent. The new carboxyl groups on the surface of nanocellulose induced by the chemical oxidization provided the possibility of participating in the construction of an alginate-based sponge's structure and played a fundamental role in the structural and mechanical stability of ensuing sponges. Furthermore, enhanced mechanical strength induced by oxidized cellulose nanocrystals and the formation of a semi-interpenetrating polymer network from oxidized microfibrillated cellulose were reported. Together with the facile and ionic crosslinking process, the ultrahigh porosity, promising water absorption and retention, as well as the improved compression strength of the crosslinked sponges should significantly extend the use of this soft material in diverse practical applications.

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Section: Introductionmentioning

confidence: 99%

TEMPO-Oxidized Nanocellulose Participating as Crosslinking Aid for Alginate-Based Sponges

Lin

Bruzzese

Dufresne

2012

ACS Appl. Mater. Interfaces

292

184

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“…For the mechanic test, circular, 10 cm diameter, and 5 mm thickness of Teflon plate mold was used. The molds were frozen overnight at À80 C and lyophilized at À80 C under 0.1 mBar for 24 h. 18 After lyophilization, the scaffolds cross-linked with epichlorohydrin at 70 C for 24 h. 19 The scaffolds were washed with PBS several times. Finally, Alginatenanohydroxyapatite (Alg-nHA), alginate-triacetin-nanohydroxyapatite (Alg-TA-nHA), alginate-tributyl citrate-nanohydroxyapatite (Alg-TBC-nHA) scaffolds obtained.…”

Section: Fabrication Of Scaffoldsmentioning

confidence: 99%

The effect of alginate scaffolds on bone healing in defects formed with drilling model in rat femur diaphysis

et al. 2023

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Alginate (ALG) is a biocompatible and biodegradable polymer. Mechanical weakness is one of the main problems for the alginate-based scaffolds. Various plasticizer additives or modifications tested to improve the mechanical properties. In the presented study, ALG plasticized with triacetin (TA), and tributyl citrate (TBC) than tested on bone healing. In the presented study, the alginate modified with triacetin or tributyl citrate. In-vitro, and in-vivo efficiency of the scaffolds tested on bone tissue regeneration. Scaffolds fabricated by solvent casting, and physicochemical characterizations performed. Monocytes (THP-1) cultured with scaffolds, and macrophage-released cytokines was determined. In-vivo efficacy of the scaffolds was tested in the rat drill hole model. Alginate and tributyl citrate-modified scaffolds have no cytotoxic effect on osteoblastic cells (MC-3T3). Tributyl citrate modification increased tumor necrosis factor-alpha (TNF-alpha) level but did not increase interleukin -1 beta (IL-1 beta) level. In vivo studies showed that osteoblastic growth was significant in alginate and triacetin-modified scaffolds. However, the best values for osteoclastic activity and osteoid tissue formation seen in the triacetin modification. The results demonstrated that the modified alginate scaffolds were more successful than non-modified alginate scaffolds and can used as long-term bone repairing treatments.

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“…7 Anisotropically ordered capillaries and micrometer sized pores have been formed in alginate based polyelectrolyte solution by a dissipative convective process followed by freeze drying. 8,9 Khan et al have successfully synthesized composite gel sponges of alginate/carboxymethyl cellulose, encapsulated with various nanoparticles and crosslinked with calcium (Ca). 10 Carboxymethylcellulose (CMC) is a water-soluble anionic linear polysaccharide made up of linear b-(1 -4)-linked glycans that exhibit polyelectrolyte characteristics due to the presence of weakly acidic groups.…”

Section: Introductionmentioning

confidence: 99%

“…14 An effective approach for improving the properties and potential applications of alginate based composites is to form organic-inorganic composites through the incorporation of nanofillers, such as clays, metal nanoparticles (Au, Ag, Fe 3 O 4 , TiO 2 , SiO 2 ), carbon nanotubes and graphene oxide. [8][9][10]15,16 Among these, gold nanoparticles (Au-NPs) and GO gain considerable attention due to their unique physicochemical, electrical, optical, thermal and mechanical properties. Moreover, they are used in a wide range of applications such as in adsorbents for environmental pollutants, electrochemical devices, electromechanical resonators, batteries, ultracapacitors, biosensors, light-emitting devices and catalysts.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of hierarchically organized nanocomposites of Ba/alginate/carboxymethylcellulose/graphene oxide/Au nanoparticles and their catalytic efficiency in o-nitroaniline reduction

et al. 2015

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Composite gels of Ba/Alginate(Alg)/Carboxymethyl Cellulose (CMC) were prepared by dissipative convective phenomenon. Graphene oxide (GO) and Au nanoparticle (Au-NPs) were successfully encapsulated into polysaccharide matrix. The resulting composite gels were characterized by Fourier Transform Infra-red spectrometry (FTIR), Raman spectroscopy, Powder X-Ray diffractometer (PXRD) technique, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Rheological and Mechanical behaviors of composite gels were also investigated. The resulting composite gels were tested for the reduction of o-nitroaniline (o-NA), to 1, 2-benenediamine in presence of NaBH4. Ba/Alg/CMC/GO/Au composite gels shows reduction of o-NA within 3 min with a rate constant of 0.45s -1 and composite can be recycled up to 4 successive cycles. IntroductionPolymer matrixes have advantage in tuning the guest-host interaction for furnishing well defined spatial distribution, highlighting kinetic stability for metal nanoparticles and also can provide good mechanical properties for the composites. Polymeric hydrogels create considerable interest because of their high degree of shrinking and swelling properties that are controlled by stimuli such as solvent polarity, solutes, pH, temperature, electric field and light. 1-3 Among polymeric hydrogels, natural polysaccharides (alginate, chitosan, cellulose, starch etc.) based composite hydrogels have attracted great interest in the field of biomedical and environmental applications due to their biocompatible, biodegradable and non-toxic abilities. 4-6 Sodium alginate (Na-Alg) is a binary heteropolymer containing varying proportions of 1,4-linked α-L guluronic acid (G-blocks) and β-D-mannuronic acid (M-blocks) units in a pyranose form, arranged in linear blocks. 7 Anisotropically ordered capillaries and micrometer sized pores have been formed in alginate based polyelectrolyte solution by dissipative convective phenomenon followed by freeze drying technique. 8-9 Khan et al. have successfully synthesized composite gel sponges of alginate/Carboxymethyl cellulose encapsulated with various nanoparticles and crosslinked with calcium (Ca). 10 Carboxymethylcellulose (CMC) is a water-soluble anionic linear polysaccharide and made up of linear β-(1→4)-linked glycanes that exhibit polyelectrolyte characteristics due tothe presence of weakly acidic groups. 11 CMC has a tremendous potential for use in site-specific or controlled-release drug delivery systems owing to its high biocompatibility, biodegradability, and low immunogenicity. [12][13] Recently, carboxymethylcellulose (CMC) and sodium alginate (Na-Alg) based novel superabsorbent hydrogel has been synthesized using methylenebisacrylamide (MBA) as a crosslinking agent. 14 An effective approach for improving properties and potential applications of alginate based composites is to form organic-inorganic composites through incorporation of nanofillers, such as clays, metal nanoparticles (Au, Ag, Fe3O4, TiO2, SiO2), carbon nanotubes and graphene oxide h...

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Dissipative convective structures and nanoparticles encapsulation in Cu/alginate/dextran composite hydrogels and sponges

Cited by 10 publications

References 14 publications

TEMPO-Oxidized Nanocellulose Participating as Crosslinking Aid for Alginate-Based Sponges

TEMPO-Oxidized Nanocellulose Participating as Crosslinking Aid for Alginate-Based Sponges

The effect of alginate scaffolds on bone healing in defects formed with drilling model in rat femur diaphysis

Fabrication of hierarchically organized nanocomposites of Ba/alginate/carboxymethylcellulose/graphene oxide/Au nanoparticles and their catalytic efficiency in o-nitroaniline reduction

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