Disseminated Porokeratosis and Myelodysplastic Syndrome

Luelmo-Aguilar, Jesus; González-Castro, U.; Mieras‐Barceló, C.; Castells‐Rodellas, A.

doi:10.1159/000247571

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…To our knowledge, this association of small bullae with DSAP has not been described previously. This bullous exacerbation was not associated with an immunosuppressive treatment [4], a malignant tumor [8, 9]or an autoimmune disease [10]. …”

Section: Discussionmentioning

confidence: 99%

“…Reed and Leone [20]have suggested that in a genetically predisposed individual, the disease results from the proliferation of abnormal clones of epidermal cells, which may be triggered by several stimuli, including sunlight or artificial UV light [18, 21, 22], exposure to electron beam radiotherapy [23], immunosuppressive treatments (as e.g. chemotherapy, immunosuppressive drugs or systemic corticosteroids) [4, 5, 6, 7, 8, 9, 10]or HIV infection [11]. A pathogenetic relationship between a latent virus infection and porokeratosis has been hypothesized, although never demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…The histopathological characteristic is the so-called cornoid lamella (a column of parakeratotic cells). Porokeratosis has also been previously reported in association with: drug-induced immunosuppression [4]; organ transplantation [5, 6, 7]; hematological malignancies [8, 9]; autoimmune disorders [10], or human immunodeficiency virus (HIV) infection [11]. …”

Section: Introductionmentioning

confidence: 99%

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Bullous and Pruritic Variant of Disseminated Superficial Actinic Porokeratosis: Successful Treatment with Grenz Rays

Ricci¹,

Rosset

Panizzon³

1999

Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bullous and Pruritic Variant of Disseminated Superficial Actinic Porokeratosis: Successful Treatment with Grenz Rays

Ricci¹,

Rosset

Panizzon³

1999

Dermatology

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“…We present the second known case of PK in a patient with MDS. 10 On the basis of two case reports, the sudden appearance of disseminated PK does not necessarily justify the search for an underlying immunosuppressive disease. However, clinicians should be aware of the potential association, and patients should be evaluated in the appropriate clinical context.…”

Section: Discussionmentioning

confidence: 99%

Superficial disseminate porokeratosis in a patient with myelodysplastic syndrome

Levin

Heymann

1999

Int J Dermatology

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NJ 08053[TAB]A 70‐year‐old man was admitted with a diagnosis of myelodysplastic syndrome (MDS) and fever of unknown origin. He had been diagnosed with MDS 2 months prior to admission, and was treated initially with the anabolic androgen, Danazol. He had also been on prednisone, 60 mg a day for a few months for the treatment of hemolytic anemia. Two weeks later, he noted the development of a mildly pruritic rash over his trunk and extremities. He denied any previous history of a similar rash as well as any family history of similar lesions. It was thought that he was having an allergic reaction to the Danazol and, therefore, Danazol was discontinued. The rash seemed to improve but flared again a few days prior to admission. Upon admission, his laboratory data revealed hemoglobin 9.3 gm/DL, hematocrit 27.3%, white blood cell count 3300/mm3 and platelet count 41,000/mm3. A bone marrow biopsy showed a hypercellular marrow. Chromosome analysis of the bone marrow revealed a complex karyotype including the loss of chromosomes 5 and 7, the presence of an isochromosome for the entire long arm of chromosome 17, and the presence of an additional chromosome 21; these are characteristic chromosome aberrations in myelodysplastic syndromes. Physical examination demonstrated discrete, small, thread‐like, annular papules over the trunk and extremities ( Fig. 1). A skin biopsy was performed and was compatible with porokeratosis showing a typical cornoid lamella ( Fig. 2). He was not given any treatment for his skin lesions and treatment for his MDS consisted solely of red cell concentrates. 1 Multiple annular papules with a thread‐like border as seen in porokeratosis 2 A typical cornoid lamella characteristic of porokeratosis

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“…Immunosuppression associated with malignancy and chemotherapy may exacerbate or initiate the development of porokeratosis in patients predisposed to alterations in eutaneous growth dynamics [43]. Mibelli's porokeratosis has been reported secondary to hepatic or renal transplantation [44,45] and Chernosky's porokeratosis has bee reported seeondary to immunosuppressors [46,47], plasmapheresis [48], pemphigus foliaceus treatment [49] and myelodysplastic syndrome [50].…”

Section: Discussionmentioning

confidence: 99%

Palmar filiform or spiny hyperkeratosis associated with pulmonary tuberculosis

Giménez-Arnau

Camarasa

1994

Acad Dermatol Venereol

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A case of palmar fihform or spiny hyperkeratosis in a 50-year-old man is reported. The development of pulmonary tuberculosis was followed by "music box spine" keratotic plugs and pits on both hands, apart from the palmar creases. Histological examination revealed a well delineated column of hyperkeratosis with basal parakeratosis not developing a true cornoid lamella.This case is interesting because of its rarity, the lack of heredity and the clinical association with pulmonary tuberculosis, although Herman (1973) reported bronchial carcinoma with punctate porokeratosis. We discuss the relationship between immunosuppression and the development of these cutaneous lesions. We also review cases described as "porokeratosis punctata palmaris et plantaris" clinically identical to our patient, who did not present true cornoid lamella. Palmar filiform hyperkeratosis is an unespecific keratinization disorder which could be considered secondary to other diseases.

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Disseminated Porokeratosis and Myelodysplastic Syndrome

Cited by 15 publications

References 4 publications

Bullous and Pruritic Variant of Disseminated Superficial Actinic Porokeratosis: Successful Treatment with Grenz Rays

Bullous and Pruritic Variant of Disseminated Superficial Actinic Porokeratosis: Successful Treatment with Grenz Rays

Superficial disseminate porokeratosis in a patient with myelodysplastic syndrome

Palmar filiform or spiny hyperkeratosis associated with pulmonary tuberculosis

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