Disseminated endosalpingiosis associated with bilateral papillary serous cystadenocarcinoma of the ovaries

Schuldenfrei, Richard; Janovski, N.A.

doi:10.1016/0002-9378(62)90136-9

Cited by 25 publications

(6 citation statements)

References 14 publications

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“…As well as being linked to SBTO (5,11,12), there have also been associations with primary papillary peritoneal neoplasia of low malignant potential (13) and less commonly cystadenocarcinomas (14). Aside from this, there was no other literature commenting on higher rates of any gynecologic malignancy with endosalpingiosis.…”

Section: Discussionmentioning

confidence: 96%

What is endosalpingiosis?

Prentice

Stewart

Mohiuddin

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 96%

What is endosalpingiosis?

Prentice

Stewart

Mohiuddin

et al. 2012

Fertility and Sterility

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“…This is further support the notion that high-grade serous carcinomas develop de novo and do not develop from benign or borderline lesions. Third, endosalpingiosis -which consists of one layer of well-demarcated columnar-to-cuboidal cells including ciliated cells -is frequently seen in the ovary and has been associated with serous cystadenocarcinoma suggesting that endosalpingiosis may represent the precursor for serous tumors [65][66][67].…”

Section: Morphologic Evidencementioning

confidence: 99%

Etiology and Pathogenesis of Epithelial Ovarian Cancer

et al. 2007

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Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critical role in the initiation of the disease. The interaction between such a microenvironment, genetic polymorphisms, and different epithelial components such as endosalpingiosis, endometriosis, and ovarian inclusion cyst in the ovarian cortex may induce different genetic changes identified in the epithelial component of different histological types of ovarian tumors. Genetic studies on different histological grades and types provide insight into the pathogenetic pathways for the development of different disease phenotypes. However, the link between all these genetic changes and the etiological factors remains to be established.

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“…The site most commonly described, however, is the ovary: both on the ovarian surface (Sinykin 1960) and in the lining of ovarian cysts (Powers & Hooker 1948). Peritoneal endosalpingiosis has been reported in association with malignant ovarian lesions (Taylor 8 Alsop 1932;Schuldenfrei & Janovski 1962;Sinykin 1960;Burmeister et ul. 1969) and this finding can lead to overdiagnosis of malignant spread.…”

Section: Discussionmentioning

confidence: 99%