Disseminated atypical tuberculosis antedating the clinical onset of neoplasia

DiBella, Nicholas J.; Buchanan, Bruce D.; Koontz, Clyde H.

doi:10.1002/1097-0142(197709)40:3<1276::aid-cncr2820400342>3.0.co;2-x

Cited by 14 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been demonstrated that hematological abnormalities are detected in severe pulmonary and in disseminated TB. Anemia, monocytosis, basophilia, leukocytosis, leucopenia, and “leukemoid reactions” are some of these abnormalities found [12–14, 20]. Otherwise, a recent study demonstrated that many patients with TB presented normal blood inflammatory markers [21].…”

Section: Discussionmentioning

confidence: 99%

“…It is probably associated to the possibility that the innate immunity may clear the infection before the induction of the acquired T-cell response [11]. Also, many hematological abnormalities, such as leucocytosis, monocytosis, or anemia, have been observed in TB patients, especially in severe disease, and may be valuable markers to diagnosis [12–14]. However, there is still a lack of available information about the relation between the hematological status and the infection occurrence after certain exposure to pulmonary TB patients (index cases).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection

et al. 2013

View full text Add to dashboard Cite

The Mycobacterium tuberculosis (M. tb) infection is largely spread in world’s population. Most infected individuals develop latent tuberculosis infection (LTBI). Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are the available tests to detect the infection. It has been reported that some individuals take a longer period of time to develop the infection than others with the same exposure level. It is suggested that the innate immunity, in which neutrophils have an important protective role, is responsible for this. Many hematologic abnormalities have been described as common findings during severe disease. To investigate if these changes are related to LTBI development and if they interfere in TST and IFN-γ production, we recruited 88 household contacts of tuberculosis (TB) pulmonary patients and compared blood cell counts with these tests’ results. There were no statistically significant changes in hemoglobin, hematocrit, platelets, global leukocyte, neutrophils, basophils, eosinophils, typical lymphocytes, atypical lymphocytes, and monocytes counts between infected and noninfected individuals. Also, there was no correlation between TST or IGRA and blood cell counts. These results suggest that blood cell counts are not LTBI markers and do not interfere in TST results or IFN-γ levels obtained by IGRA.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Darüber hinaus gibt es Fallbeschreibungen, bei denen die Manifestation einer Tbc bis zu 4 Jahre vor dem Auftreten eines Morbus Hodgkin bzw. einer akuten myeloischen Leukämie erfolgte, so dass postuliert werden kann, dass eine gestörte zelluläre Immunität mögli-cherweise bereits mehrere Jahre vor der klinischen Manifestation einer Neoplasie existiert [12].…”

unclassified