Dissecting the fatigue experience: A scoping review of fatigue definitions, dimensions, and measures in non-oncologic medical conditions

Billones, Ruel; Liwang, Josephine; Butler, Kierra; Graves, Letitia Y.; Saligan, Leorey N.

doi:10.1016/j.bbih.2021.100266

Cited by 54 publications

(59 citation statements)

References 72 publications

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“…Fatigue might be translated as “extreme and persistent tiredness, weakness or exhaustion that could be mental, physical or both” ( 56 ), but there is no further agreement on the definition of this entity ( 57 ). Fatigue can cooccur with clinical symptoms such as depression, pain, sleep impairment, and cognitive dysfunction ( 58 ) and can be associated with chronic medical conditions (e.g., postviral infection, cancer, inflammatory bowel disease, multiple sclerosis, depression, and fibromyalgia ( 59 )).…”

Section: Critical Appraisal Of Pet and Spect Literaturementioning

confidence: 99%

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

et al. 2022

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Molecular imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have been used to shed light on how the Corona Virus Disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to five predominant topics: 1. Few case reports suggest reversible cortical and subcortical metabolic alterations in rare cases with concomitant, para-or post-infectious encephalitis. 2. Imaging findings in single patients with first manifestations of parkinsonism in the context of COVID-19 resemble those in neurodegenerative parkinsonism (loss of nigrostriatal integrity), but scarceness of data and a lack of follow-up preclude further etiological conclusions (e.g., unmasking/hastening of neurodegeneration vs. (para-) infectious parkinsonism). 3. Several case reports and few systematic studies addressed focal symptoms and lesions, most notably hyposmia. Results are variable, although some studies found regional hypometabolism of regions related to olfaction (e.g., orbitofrontal and mesiotemporal). 4. A case series and systematic studies in inpatients with COVID-19-related encephalopathy (acute to subacute stage) consistently found a frontoparietal-dominant neocortical dysfunction (on imaging and clinically) that proved to be grossly reversible in the majority of cases until 6 months. 5. Studies in "Post-COVID-19 syndrome" provided controversial results. In patients with a high level of self-reported complaints (e.g., fatigue, memory impairment, hyposmia, dyspnea) some authors found extensive areas of limbic and subcortical hypometabolism, while others found no metabolic alterations on PET and only minor cognitive impairments (if any) on neuropsychological assessment. Furthermore, we provide a critical appraisal of studies in regard of frequent methodological issues and current pathophysiological concepts. Finally, we devised possible applications of PET and SPECT in the clinical work-up of diagnostic questions related to COVID-19.

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Section: Critical Appraisal Of Pet and Spect Literaturementioning

confidence: 99%

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

et al. 2022

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“…Critics suggest the latter is less "scientific," as there is not an observer-based measurement and there are accusations of inherent problems of reproducibility that can lie within this. 30 But paradoxically, this approach shows a substantially improved correlation with patient-related outcome measures.…”

Section: Fatigue In the Context Of Neurological Diseasementioning

confidence: 99%

Cognitive Behavioral Therapy: Principles, Science, and Patient Selection in Neurology

Carson

McWhirter

2022

Semin Neurol

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Cognitive behavioral therapy (CBT) is a widely used therapeutic modality in general psychiatric practice. In this review, we consider its application to neurological disorders. We examine the basic framework of CBT—that symptoms, emotions, thoughts, and behaviors are all interrelated and that therapeutic interventions that lead to change in thoughts or behavior may have the potential to reduce symptoms or emotional distress. We also outline specific methodological issues to consider when reading or planning studies of CBT interventions, highlighting important topics pertaining to quality control, control group selection, dropouts, and generalizability. We then review the evidence base for CBT's use across a range of neurological disorders. In doing so, we highlight where there is a clear evidence base, and where it is a technique with potential. The review is targeted at a general neurology audience as introduction to the topic not as an advanced guide for expert practitioners.

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“…Fatigue kann Gesunde betreffen, aber auch sekundär auftreten (z. B. postviral, tumorassoziiert, chronisch entzündliche Darmerkrankungen, Multiple Sklerose; [ 6 ]). Zudem bestehen Symptomüberlappung und Komorbidität mit psychischen Erkrankungen.…”

Section: Klinische Aspekteunclassified

Post-COVID-Syndrom – Fokus Fatigue

Hellwig

Domschke

2022

Nervenarzt

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Die Weltgesundheitsorganisation (WHO) definiert Post-COVID-19(„coronavirus disease 2019“) als Zustand, der bei Personen mit einer anamnestisch wahrscheinlichen oder bestätigten SARS-CoV-2(„severe acute respiratory syndrome coronavirus type 2“)-Infektion 3 Monate nach Beginn der COVID-19-Symptome und mindestens 2 Monate andauernd vorhanden ist und durch eine alternative Diagnose nicht erklärbar ist. Kernsymptome des Post-COVID-Syndroms umfassen Atemnot, Fatigue und kognitive Dysfunktion, welche das alltägliche Funktionsniveau beeinflussen. Neuropsychiatrische Spätfolgen sind bei COVID-19-Patienten mit Inzidenzraten von über 30 % häufig. Neben den genannten Kernsymptomen zeigen Schlafstörungen, Depression und Angsterkrankungen erhöhte Inzidenzen. Nach gegenwärtiger Meinung werden assoziierte neuropsychiatrische Symptome sowohl unter dem Begriff Post-COVID-Syndrom subsumiert, aber auch als Komorbiditäten interpretiert, welche die Manifestation eines Post-COVID-Syndroms begünstigen können. So zeigt das Kernsymptom Fatigue Symptomüberlappung und Komorbidität mit psychischen Erkrankungen. Bildgebungsstudien deuten auf ein organisches Korrelat der Fatigue bei Post-COVID-Patienten hin, darüber hinaus wurden psychosoziale Aspekte und psychiatrische Komorbiditäten wie Depression und Angsterkrankungen als modulierende und damit potenziell behandelbare Faktoren identifiziert. Die Therapie der Fatigue umfasst neben dem pharmakologischen Management mit u. a. Stimulanzien und Antidepressiva auch nichtpharmakologische Strategien, hier vor allem die kognitive Verhaltenstherapie sowie körper- und bewegungsfokussierte Interventionen. Die Evidenz hierfür erwächst aus Metaanalysen bei tumorassoziierter oder postviraler Fatigue.

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Dissecting the fatigue experience: A scoping review of fatigue definitions, dimensions, and measures in non-oncologic medical conditions

Cited by 54 publications

References 72 publications

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

Cognitive Behavioral Therapy: Principles, Science, and Patient Selection in Neurology

Post-COVID-Syndrom – Fokus Fatigue

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