Post-COVID-Syndrom – Fokus Fatigue

Hellwig, Sabine; Domschke, Katharina

doi:10.1007/s00115-022-01306-1

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…Previous studies have shown that fatigue constitutes the most important complication after COVID‐19 (Chen et al., 2022 ; Hellwig & Domschke, 2022 ), in both hospitalized and non‐hospitalized patients (Petersen et al., 2021 ). In a meta‐analysis of 19 studies, it was found that fatigue was reported by one third of individuals with the SARS‐CoV‐2 infection at any time point (Healey et al., 2022 ); however, according to some systematic reviews, its prevalence could be even higher, with more than 50% of affected patients (Lopez‐Leon et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Fatigue after COVID‐19 in non‐hospitalized patients according to sex

et al. 2023

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Background Limited evidence exists on sex differences in post‐COVID fatigue among non‐hospitalized patients. Therefore, aim of the study was to evaluate the course of chronic fatigue symptoms in non‐hospitalized subjects with the SARS‐CoV‐2 infection, according to sex. Methods Patients and staff from the University Hospital in Krakow anonymously and retrospectively completed neuropsychological questionnaire that included eight symptoms of chronic fatigue syndrome. The presence of these symptoms was assessed before COVID‐19 and 0–4, 4–12, and >12 weeks postinfection. The inclusion criteria were as follows: age 18 or more years, >12 weeks since the onset of the SARS‐CoV‐2 infection, and diagnosis confirmed by the RT‐PCR from anasopharyngeal swab. Results We included 303 patients (79.53% women, 47.52% medical personnel) assessed retrospectively after a median of 30 (interquartile range: 23–35) weeks since the onset of symptoms. A higher prevalence of at least one chronic fatigue symptom was found in females in all time intervals after the onset of COVID‐19 compared to males (p < .036). Women, compared to men, more often experienced persistent fatigue, not caused by effort and persisting after rest (for <4 weeks, odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.13–4.73; for 4–12 weeks, OR = 1.95, 95% CI: 1.06–3.61), non‐restorative sleep (for <4 weeks, OR = 2.17, 95% CI: 1.23–3.81; for >12 weeks, OR = 1.95, 95% CI: 1.03–3.71), and sore throat (for <4 weeks, OR = 1.97, 95% CI: 1.03–3.78; for 4–12 weeks, OR = 2.76, 95% CI: 1.05–7.27). Sex differences in headache, arthralgia, and prolonged postexercise fatigue were observed only during the first 4 weeks (OR = 2.59, 95% CI: 1.45–4.60, OR = 2.97, 95% CI: 1.02–8.64, and OR = 1.87, 95% CI: 1.01–3.51, respectively). There were no differences between women and men in myalgia and self‐reported lymph node enlargement. Conclusions The course of post‐COVID fatigue differs significantly between sexes in non‐hospitalized individuals with COVID‐19, with women more often suffering from persistent fatigue, not caused by effort and persisting after rest, non‐restorative sleep, and sore throat.

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Section: Introductionmentioning

confidence: 99%

Fatigue after COVID‐19 in non‐hospitalized patients according to sex

et al. 2023

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“…Given a successful evaluation in further studies, such medication may enter the guidelines for the treatment of post-COVID in certain risk groups. Along the same lines, there is meta-analytical evidence suggesting that patients with tumor-associated fatigue benefit from treatment with stimulants and antidepressants (Tomlinson et al, 2018;Hellwig & Domschke, 2022). Also, other treatment methods, for example cognitive behavioral therapy seem to have an effect on both chronic depression (Hofmann et al, 2012) as well as chronic fatigue, especially in the presence of comorbid depression (Castell et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-centre, population-based cohort study

Weiß,

Gutzeit,

Appel

et al. 2024

Preprint

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Background: Depression and fatigue are commonly observed sequelae following viral diseases such as COVID-19. Identifying symptom constellations that differentially classify post-COVID depression and fatigue may be helpful to individualize treatment strategies. Here, we investigated whether self-reported post-COVID depression and post-COVID fatigue are associated with the same or different symptom constellations. Methods. To address this question, we used data from COVIDOM, a population-based cohort study conducted as part of the NAPKON-POP platform. Data was collected in three different German regions (Kiel, Berlin, Würzburg). We analyzed data from more than 2000 individuals at least six months past a PCR-confirmed COVID-19 disease, using elastic net regression and cluster analysis. The regression model was developed in the Kiel data set, and externally validated using data sets from Berlin and Würzburg. Results. Our results revealed that post-COVID depression and fatigue are associated with overlapping symptom constellations consisting of difficulties with daily activities, perceived health-related quality of life, chronic exhaustion, unrestful sleep, and impaired concentration. Confirming the overlap in symptom constellations, a follow-up cluster analysis could categorize individuals as scoring high or low on depression and fatigue but could not differentiate between both dimensions. Limitations. The data presented are cross-sectional, consisting primarily of self-reported questionnaire or medical records rather than biometrically collected data.Conclusions. In summary, our results suggest a strong link between post-COVID depression and fatigue and thus highlighting the need for integrative treatment approaches.

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“…Hossain et al (2020) highlighted the high burden of mental health problems associated with COVID-19, including depression, anxiety disorders, stress, and other psychological impacts. Hellwig & Domschke (2022) discussed post-COVID syndrome with a focus on fatigue and neuropsychiatric late sequelae commonly observed in COVID-19 patients. A systematic review of the association between emotional eating and mental health during the pandemic was carried out by Burnatowska et al (2022).…”

Section: Promoting Physical Activity For Mental Health During and Aft...mentioning

confidence: 99%

Mental Health and Physical Activity during and after the COVID-19 Pandemic: A Review

Ahsan,

Abualait

2024

Retos

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Globally, the COVID-19 pandemic has had a significant effect on people's mental health and levels of physical activity. The purpose of this review paper is to investigate the relationship between physical activity and mental health both during and after the pandemic. It gives an overview of the challenges faced by people during and after the pandemic, the effects on mental health, and how exercise helps to counteract the negative effects. Additionally, it covers possible tactics, strategies, and interventions to encourage physical exercise and mental health after the pandemic. The results emphasize how critical it is to treat mental health issues and encourage physical activity as vital elements of overall well-being in the face of adversity. It also emphasizes the integration of mental health and physical activity into public health policies and healthcare systems. By prioritizing mental health support and promoting physical activity, individuals can better cope with the challenges posed by the pandemic and emerge stronger in its aftermath. Keywords: COVID-19, pandemic, mental health, physical activity, psychological well-being, public health, intervention.

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Post-COVID-Syndrom – Fokus Fatigue

Cited by 12 publications

References 56 publications

Fatigue after COVID‐19 in non‐hospitalized patients according to sex

Fatigue after COVID‐19 in non‐hospitalized patients according to sex

Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-centre, population-based cohort study

Mental Health and Physical Activity during and after the COVID-19 Pandemic: A Review

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