Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

Abstract

Molecular imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have been used to shed light on how the Corona Virus Disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to five predominant topics: 1. Few case reports suggest reversible cortical and subcortical metabolic alterations in rare cases with concomitant, para-or post-infectious encephalitis. 2. Imaging findings in single patients with first manifestations of parkinsonism in the context of COVID-19 resemble those in neurodegenerative parkinsonism (loss of nigrostriatal integrity), but scarceness of data and a lack of follow-up preclude further etiological conclusions (e.g., unmasking/hastening of neurodegeneration vs. (para-) infectious parkinsonism). 3. Several case reports and few systematic studies addressed focal symptoms and lesions, most notably hyposmia. Results are variable, although some studies found regional hypometabolism of regions related to olfaction (e.g., orbitofrontal and mesiotemporal). 4. A case series and systematic studies in inpatients with COVID-19-related encephalopathy (acute to subacute stage) consistently found a frontoparietal-dominant neocortical dysfunction (on imaging and clinically) that proved to be grossly reversible in the majority of cases until 6 months. 5. Studies in "Post-COVID-19 syndrome" provided controversial results. In patients with a high level of self-reported complaints (e.g., fatigue, memory impairment, hyposmia, dyspnea) some authors found extensive areas of limbic and subcortical hypometabolism, while others found no metabolic alterations on PET and only minor cognitive impairments (if any) on neuropsychological assessment. Furthermore, we provide a critical appraisal of studies in regard of frequent methodological issues and current pathophysiological concepts. Finally, we devised possible applications of PET and SPECT in the clinical work-up of diagnostic questions related to COVID-19.

2-[18F]-FDG PET for imaging brain involvement in patients with long COVID: perspective of the EANM Neuroimaging Committee

“…In addition, brain FDG PET potentially provides a differential diagnosis for clinical symptoms related to neurodegenerative diseases, encephalitis/encephalopathy, or psychiatric disorders. In our opinion, and as previously proposed by Meyer et al [ 21 ], this examination should be considered in these two frameworks only after a dedicated clinical evaluation and after a significant delay (3 to 6 months) from the initial infection, or in case of worsening [ 19 ]. Clinicians should remember that cerebral symptoms of long COVID are not limited to cognitive complaints, and consequently, a broader evaluation should be considered beyond the neuropsychometric assessment for these PET indications, especially considering dysautonomia.…”

Orbito-Frontal Cortex Hypometabolism in Children With Post-COVID Condition (Long COVID): A Preliminary Experience

“…Importantly, further studies are needed to better understand which children deserve third-level imaging such as brain 18 F-FDG PET, also for radiation issues, since a recent review has demonstrated both pathological and normal imaging studies in patients with chronic neuropsychiatric problems. 10 Lastly, our findings highlight the possibility of a neurotropic effect of the viral infection, either direct or indirect through neuronal transcriptome changes occurring after infection of the neuronal cells. In this regard, Sars-Cov2 infection has been shown to induce the rearrangement of neuronal nuclear architecture.…”

Post-COVID-Syndrom – Fokus Fatigue

“…Eine aktuelle Übersicht zu FDG-PET-Studien und bildgebenden Befunden bei COVID-19-assoziierten Erkrankungen des Zentralnervensystems (ZNS) bieten Meyer et al [ 33 ]. Hier werden zudem methodische Aspekte kritisch diskutiert, welche zur kontroversen Datenlage beim Post-COVID-Syndrom beitragen.…”