Disorders of Hyperpigmentation

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

“…Under illumination with Wood's lamp, the pigment may be seen at several levels of epidermis and dermis. However, histological findings do not correlate well with reported Wood's light examination findings 91,92 . In the dermal layer, there is usually an increase in melanin-containing macrophages.…”

Melasma, Melasma-Like Lichen Planus Actinicus, and Butterfly Lichen Planus Actinicus Build up One Spectrum (Clinico-Histopathological Study)

“…Facial melanosis is a major cosmetic problem among people especially in people with dark complexion and we can categorise the commonest causes of facial melanosis as follows [1]- [3].…”

Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma

“…Conclusions: Considering the anti-melanogenic activity and human safety, CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders. and accumulation of melanin in the skin could be a serious skin disorder and aesthetic problems, which are decreasing social functioning, reducing productivity at work or school, and lowering the self-esteem of patients [3][4][5][6] . Melanogenesis is regulated by various environmental, hormonal and genetic factors, including α-melanocyte stimulating hormone, theophylline, cAMP-elevating agents, and estrogen, and UV light.…”

“…Cellular tyrosinase activity was measured by the method of Yen (1) rutin, (2) narirutin, (3) naringin, (4) hesperidin, (5) neohesperidin, (6) neohesperidin dihydrochalcone, (7) naringenin, (8) hesperetin, (9) aprgrnin, (10) nobiletin, (11) tangeretin, (12) auraptene was diluted with ethanol to obtain a series concentration of working solutions, and subjected to HPLC analysis.…”