Disorders associated with hyperuricemia

Smyth, Charley J.

doi:10.1002/art.1780180712

Cited by 30 publications

(14 citation statements)

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“…and various loop diuretics have been generally utilized as useful antihypertensive agents, but the hyperuricemic effect incident to their major effects has sometimes necessitated their withdrawal (1)(2)(3). Uricosuric (generally used to mean 'hyperuricosuric') diuretics have been studied over the past decade to im prove diuretic antihypertensives.…”

Section: Diuretic Thiazidesmentioning

confidence: 99%

A new uricosuric diuretic, S-8666, in rats and chimpanzees.

et al. 1987

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Abstract-5Dimethylsulfamoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid (S-8666) was studied as a possible new uricosuric diuretic agent using rats and chimpanzees.Various new compounds belonging to the 5-sulfamoyl-6,7 dichloro-2,3-dihydrobenzofuran-2-carboxylic acids were clearly diuretic with uricosuric activity in intraperitoneally oxonate-treated rats. S-8666 was chosen as a favorable candidate because its uricosuric activity due to the effects of tubular transport of uric acid were apparently more marked than those of known uricosuric agents such as probenecid, benzbromarone, tienilic acid and indacrinone in oxonate treated rats. S-8666 was also uricosuric in rats not given urate oxidase inhibitor. The diuretic effect of S-8666 in oxonate-treated rats was as high-ceilinged as that of furosemide, while those of tienilic acid, indacrinone and a known compound of a 5-carbonyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid were rather low-ceilinged.These uricosuric and diuretic activities of S-8666 were manifested by two enantiomers, of which the (+)-enantiomer displayed predominantly uricosuric activity and the (-)-enantiomer, diuretic activity like furosemide. The new compound was also uricosuric and diuretic in chimpanzees, although the potency of the uricosuric activity was similar to that of probenecid and less than that of indacrinone.Thus, it seems that S-8666 is a different type of uricosuric diuretic from known agents which have already been tried in humans.

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Section: Diuretic Thiazidesmentioning

confidence: 99%

A new uricosuric diuretic, S-8666, in rats and chimpanzees.

et al. 1987

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“…Primary is involved with hereditary or inborn error while the secondary is an acquired disorder. The mechanism of hyperuricemia is the same in both categories; it is due to either increased turnover of nucleic acid purines or to a renal impairment in the excretion of uric acid [6].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Uric acid Monitoring Device using Near-Infrared Spectroscopy

Kim¹

2015

J Biosens Bioelectron

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“…Hyperuricemia incident to the treatment with diuretics is well recognized (1)(2)(3)(4)(5)(6), and obstruction in the renal transport system of uric acid has been discussed as the cause (2-6).…”

mentioning

confidence: 99%