Decreased renal excretion of uric acid following diuretic administration in rats.

Hypotensive and uric acid-retaining effects of trichlormethiazide under dietary sodium restriction in spontaneously hypertensive rats.

“…Also, we previously reported that not only the decrease of inulin clearance but that of fractional excretion of uric acid under acute treatment with tri chlormethiazide could be completely cor rected by saline loading (5 (20) indicated that the fecal excretions of sodium and potassium were only few percentages of their urinary excretions in rats fed a synthetic diet containing 150 mEq of sodium and potassium/kg of food. Accordingly, the "cumulative balance" in this report was determined from the difference between the amount of intake and that of the urinary output.…”

“…We previously reported that the characteristics of diuretics acting on uric acid retention could be understood in renal clearance studies using normotensive rats (4,5) and showed that consecutive administration of trichlormethiazide led to much greater diuresis with deterioration of the uric acid excretory capacity when dietary sodium was restricted than when a normal laboratory diet was given (4). A clinical study has also shown that the combination of a low sodium diet and thiazide diuretics induces hyperuricemia due to decreased uric acid clearance (6).…”

“…On the final day (day 14), a clearance study was performed in order to determine the changes in the renal handling of uric acid in accordance with the method described previously (5). An infusion medium was given at 2 ml/hr, and then three 20-min urine samples were collected and blood samples were collected at the midpoint.…”

The Uricosuric Effect in Rats of E5050, a New Derivative of Ethanolamine, Involves Inhibition of the Tubular Postsecretory Reabsorption of Urate

“…The observation that E5050 increased CURATE/CINULIN without any change in GFR indicates that the drug affects the urate-transport system in the rat renal tubules. The pyrazinamide suppression test has been widely used to clarify the mechanisms of action of uricosuric drugs in clinical studies, but it is rarely used in studies with experimental animals (21,22), presumably because only a few experimental animals, such as the chimpanzee, Cebus monkey and DBA/2N mouse (21), conform to the four-component hypothesis in the same manner as humans. In the present study with pyrazinoic acid, an active metabolite of pyrazinamide that is a selective inhibitor of the tubular secretion of urate, the uricosuric effect of E5050 was completely inhibited by pretreatment with pyrazinoic acid.…”

Investigation of liver tissue and biochemical parameters of adult wistar rats treated with Arctium lappa L.

“…However, this study in animals suggested that caution should be taken in using A. lappa to treat human patients with kidney stones and gout, since the plasmatic levels of uric acid were somewhat increased in the treated groups. This could occur due to its diuretic property, remembering that some diuretics were known to decrease the rate of uric acid excretion (Iwaki and Yonetani, 1984). Thus, the administration of A. lappa extract in the dosage and during the period of time used did not show signs of toxicity, according to the biochemical parameters and the lack of alterations in the liver tissue.…”