Disintegration Properties of Calcium Phosphate Dibasic Dihydrate Tablets

Khan, K. A.; Rhodes, C. T.

doi:10.1002/jps.2600640141

Cited by 25 publications

(9 citation statements)

References 9 publications

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“…This finding coincided with a previous report, in which polacrilin postassium (Amberlite IRP88®) was used as a disintegant for a directly compressed tablet made from DCP [17]. When the pressure is lowered, the particles tend not to consolidate, thus resulting in a softer tablet with a relatively coarser pore size [18,19].…”

Section: Discussionsupporting

confidence: 91%

“…As the hardness of the tablet decreases, the time taken for the entry of the fluid and swelling of the resin with subsequent tablet disintegration decreases through an increase in porosity [10,19]. Under this condition, however, the resin cannot exert enough swelling force in such an enlarged pore to produce an immediate disintegration of the tablet [17]. In this case, the latter effect was predominant, thus causing the increased disintegration time with the decrease in the compression pressure.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of some anionic exchange resins as potential tablet disintegrants

Akkaramongkolporn

Pattarakan²,

Opanasopit³

et al. 2014

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Evaluation of some anionic exchange resins as potential tablet disintegrants

Akkaramongkolporn

Pattarakan²,

Opanasopit³

et al. 2014

Trop. J. Pharm Res

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“…The idea for the development of IRPs came from commercially available naphthalene balls and phosphine tablets. 24,25 Encapsulation technology 26,27 was used in IRPs to bring about the controlled release of the active components for a longer time. The IRP can be kept inside a sachet and stored along with the grains, which will allow for easy removal after the set period of grain storage.…”

Section: Introductionmentioning

confidence: 99%

“…Insect repellent pellets (IRPs) were developed to manage the insects that infect stored products. The idea for the development of IRPs came from commercially available naphthalene balls and phosphine tablets 24,25 . Encapsulation technology 26,27 was used in IRPs to bring about the controlled release of the active components for a longer time.…”

Section: Introductionmentioning

confidence: 99%

Insect repellent pellets – an application of botanicals against red flour beetle – their antifungal activity during storage and use as potential fumigants

Mangang

Manickam

2022

J Sci Food Agric

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BACKGROUND: The protection of grains from insect infestation is critical during storage. Insect repellent pellets (IRPs) are a potential technique to repel insects by hindering insect movement toward the grains. The basic principle of IRPs is the use of active components found in the oils of lemongrass, eucalyptus, and neem leaves for the controlled release of fumes, thereby avoiding the need for reapplication after a few days. Here, we examined the antifungal activity, the lethal dose, and the repelling effect of IRPs against red flour beetle, Tribolium castaneum, over a 30 day period. RESULTS: We observed that IRPs possessed antifungal properties and were able to repel the adults of T. castaneum. These insects ultimately died from the fumes if they manage to stay near the IRPs (LD 50 = 2 and LD 99 = 7 days). The active components (phenol, 2,4-di-tert-butyl-, citral, neral, geraniol, n-hexadecanoic acid) present in IRP during the initial stage were also found after a storage period of 35 days.CONCLUSION: The active components present in IRPs have antifungal, repellent, and fumigant properties. The IRPs can thus be termed potent botanical insecticides and are an alternative to synthetic insecticides.

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“…Some of the factors which may affect the performance of disintegrants are particle size (5), molecular structure (6), compression force (7,8), method of incorporation in granulation (9,10), prior history of wetting (11), and compression (reworking) of the disintegrants (12,13). Hancock et al (14) studied the effect of sorbed moisture on some pharmaceutical sugars by studying their dynamic vapor sorption.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

Bele

Derle

2011

AAPS PharmSciTech

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Abstract. Polacrilin Potassium NF is a commonly used weak cation exchange resin disintegrant in pharmaceutical tablets. The objective of this research was to evaluate the effects of sorbed moisture on physical characteristics and disintegrant performance of four brands of Polacrilin Potassium NF. The disintegrants were stored in five different relative humidity chambers and their dynamic vapor adsorption-desorption analysis, effect of moisture on their compressibility, compactability, particle size, morphology, water uptake rate, and disintegration ability were studied. Moisture seemed to plasticize the disintegrants, reducing their yield pressures. However, certain optimum amount of moisture was found to be useful in increasing the compactablity of the tablets containing disintegrants. The tablets, however, lost their tensile strengths beyond this optimum moisture content. Moisture caused two brands of the disintegrants to swell; however, two other brands aggregated upon exposure to moisture. Swelling without aggregation increased the water uptake, and in turn the disintegrant performance. However, aggregation probably reduced the porosities of the disintegrants, reducing their water uptake rate and disintegrant performance. Different brands of Polacrilin Potassium NF differed in the abilities to withstand the effects of moisture on their functionality. Effect of moisture on disintegrant performance of Polacrilin Potassium NF needs to be considered before its use in tablets made by wet granulation.

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Disintegration Properties of Calcium Phosphate Dibasic Dihydrate Tablets

Cited by 25 publications

References 9 publications

Evaluation of some anionic exchange resins as potential tablet disintegrants

Evaluation of some anionic exchange resins as potential tablet disintegrants

Insect repellent pellets – an application of botanicals against red flour beetle – their antifungal activity during storage and use as potential fumigants

Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

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