Disgust and Huntington's disease

Hayes, Catherine; Stevenson, Richard J.; Coltheart, Max

doi:10.1016/j.neuropsychologia.2006.10.015

Cited by 79 publications

(55 citation statements)

References 69 publications

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“…There is only 1 related study that showed that patients with Huntington disease classified fewer affective scenes as disgusting than healthy controls. 22 In the present investigation, we presented the participants (symptomatic patients with Huntington disease and healthy controls) with affective scenes that have been proven to elicit disgust, fear and happiness, as indicated by subjective ratings and involvement of the insula, amygdala and OFC in healthy individuals 21,23 and psychiatric patients. 24 Additionally, the participants viewed emotional facial expressions depicting happiness, fear, sadness, anger, disgust and surprise and a neutral affective state.…”

Section: Introductionmentioning

confidence: 99%

Emotion recognition and experience in Huntington disease: a voxel-based morphometry study

Ille

Schäfer

Scharmüller

et al. 2011

jpn

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Section: Introductionmentioning

confidence: 99%

Emotion recognition and experience in Huntington disease: a voxel-based morphometry study

Ille

Schäfer

Scharmüller

et al. 2011

jpn

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“…A number of studies have found a disproportionately severe deficit in disgust recognition in the pre-symptomatic (Gray, Young, Barker, Curtis, & Gibson, 1997;Hennenlotter, et al, 2004;Sprengelmeyer, et al, 2006) and symptomatic stages of the disorder Sprengelmeyer, et al, 1996;Wang, Hoosain, Yang, Meng, & Wang, 2003), and there are findings indicating that the experience of disgust itself can also be affected (Hayes, Stevenson, & Coltheart, 2007;Mitchell, Heims, Neville, & Rickards, 2005). In these studies, however, the disproportionately severe deficit with disgust is mostly found within the context of more widespread problems in emotion recognition, and especially recognition of anger (Calder, et al, 2010).…”

Section: Introductionmentioning

confidence: 98%

The neuropsychology of first impressions: Evidence from Huntington's disease

Sprengelmeyer

Young

Baldas

et al. 2016

Cortex

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Impairments of emotion recognition have been widely documented in Huntington's disease (HD), but little is known concerning how these relate to other aspects of social cognition, including first impressions of traits such as trustworthiness and dominance. Here, we introduce a novel and sensitive method to investigate the ability to evaluate trustworthiness and dominance from facial appearance, with control tasks measuring ability to perceive differences between comparable stimuli. We used this new method together with standard tests of face perception to investigate social cognition in HD. We found that a subgroup of people with HD was impaired at perceiving trustworthiness and dominance, and that perceiving trustworthiness and dominance were correlated with impaired facial expression recognition. In addition, we used diffusion tensor imaging (DTI) to provisionally identify candidate brain regions associated with social cognition by contrasting regional functional anisotropy (FA) measures between subgroups of HD participants showing normal or impaired perception of trustworthiness and dominance, and by correlating these regional brain abnormalities with behavioural performance on tests of emotion recognition. In this way we show for the first time alterations in perception of trustworthiness and dominance in people with HD and link these to regions which may map the boundaries of the social brain. The pattern of breakdown seen in this neurodegenerative disease can thus be used to explore potential inter-relationships between different components of social cognition.

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“…Studies in HD initially reported a disproportionate impairment of disgust recognition (Hayes et al, 2007;Wang et al, 2003;Sprengelmeyer et al, 1996). Later findings however suggested that other negative emotions (anger and fear) were equally, if not more affected (deGelder et al, 2008;Hayes et al, 2009;Henley et al, 2008;Milders et al, 2003;Montagne et al, 2006;Snowden et al, 2008;Ille et al, 2011;Tabrizi et al, 2009;Calder et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In HD, impairments in disgust (Hayes et al, 2007), anger and fear (Snowden et al, 2008;Calder et al, 2010) recognition have been reported across both facial and vocal modalities. The pattern of the severity of emotionspecific deficits across these stimulus types however is unclear.…”

mentioning

confidence: 99%