Diseases of connective tissue: a consensus

Gardner, D. L.

doi:10.1136/jcp.s3-12.1.223

Cited by 2 publications

(1 citation statement)

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“…Benign connective and soft‐tissue neoplasms (CSTNs) develop from structures of the connective and subcutaneous tissue. These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs 1‐5 . Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Benign connective and soft‐tissue neoplasms of the oral and maxillofacial region: Cross‐sectional study of 1066 histopathological specimens

et al. 2020

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Background: Benign connective and soft-tissue neoplasms (CSTNs) are unusual in the head and neck region. The aim of the present study was to evaluate the demographic and clinicopathological features of these neoplasms. Methods: A cross-sectional study was conducted of cases diagnosed as benign CSTNs, with data collected from biopsy records. The chi-square test was used. A p-value <0.05 was considered indicative of statistical significance. Results: Among the 38 119 specimens, 1066 (2.79%) were benign CSTNs: 369 fibroblastic/myofibroblastic, 250 adipocytic, 179 vascular, 130 neural, 94 osseous/cartilaginous, 19 muscular, and two fibrohistiocytic. Most patients were female (62.8%) and white-skinned (45.8%). Mean age was 42 years. The tongue (25.2%) was the most affected site for extraosseous neoplasms. Conclusion: This study had the largest sample of benign oral and maxillofacial CSTNs. Although these tumors have similar clinical features, the characterization and differentiation detailed here may help clinicians with regards to the correct diagnosis. K E Y W O R D S connective tissue, diagnosis, neoplasms, oral pathology, soft-tissue neoplasms 1 | INTRODUCTION Benign connective and soft-tissue neoplasms (CSTNs) develop from structures of the connective and subcutaneous tissue. These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs. 1-5 Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors. 4,5 Some of these neoplasms are rare in head and neck region, whereas others have a preference for this region. 6-55 Importantly, benign oral and maxillofacial CSTNs are associated with systemic diseases. Neural neoplasms are seen in neurofibromatosis, Noonan syndrome, and multiple endocrine neoplasia type 2B. 6 Gardner syndrome is related to bone tumors, especially osteomas, 7 and myofibromatosis is associated with myofibromas. 8 From the clinical standpoint, many oral and maxillofacial CSTNs have overlapping characteristics, which poses a challenge with regards to establishing the correct clinical diagnosis. These CSTNs usually appear as nodular or tumoral, painless, slow-growing, pink lesions

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Section: Introductionmentioning

confidence: 99%