Useful knowledge on the epidemiology, treatment and follow-up of CEOT has been provided. Demographic data and clinical features of the cases presented in this collaborative study were quite similar to those of studies reported worldwide.

Background: The aim was to analyze the frequency, clinical and demographic features of solitary and multiple/diffuse oral pigmented lesions submitted to histopathological examination, and to summarize the features that guide the clinical differential diagnosis.Methods: Clinical and demographic data were retrieved from biopsy records and descriptive statistics were performed.Results: Nine hundred and five (0.51%) oral pigmented lesions were retrieved among 177 356 specimens, being 95.9% solitary and 4.1% multiple/diffuse lesions. Regardless the overlapping clinical presentation, age, site, association with amalgam restoration, and a nodular appearance may help in the clinical differential diagnosis of solitary oral pigmentations. Patient's habits, site, and systemic signs and symptoms are helpful in the clinical differential diagnosis of multiple/diffuse lesions.

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Background: Benign connective and soft-tissue neoplasms (CSTNs) are unusual in the head and neck region. The aim of the present study was to evaluate the demographic and clinicopathological features of these neoplasms. Methods: A cross-sectional study was conducted of cases diagnosed as benign CSTNs, with data collected from biopsy records. The chi-square test was used. A p-value <0.05 was considered indicative of statistical significance. Results: Among the 38 119 specimens, 1066 (2.79%) were benign CSTNs: 369 fibroblastic/myofibroblastic, 250 adipocytic, 179 vascular, 130 neural, 94 osseous/cartilaginous, 19 muscular, and two fibrohistiocytic. Most patients were female (62.8%) and white-skinned (45.8%). Mean age was 42 years. The tongue (25.2%) was the most affected site for extraosseous neoplasms. Conclusion: This study had the largest sample of benign oral and maxillofacial CSTNs. Although these tumors have similar clinical features, the characterization and differentiation detailed here may help clinicians with regards to the correct diagnosis. K E Y W O R D S connective tissue, diagnosis, neoplasms, oral pathology, soft-tissue neoplasms 1 | INTRODUCTION Benign connective and soft-tissue neoplasms (CSTNs) develop from structures of the connective and subcutaneous tissue. These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs. 1-5 Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors. 4,5 Some of these neoplasms are rare in head and neck region, whereas others have a preference for this region. 6-55 Importantly, benign oral and maxillofacial CSTNs are associated with systemic diseases. Neural neoplasms are seen in neurofibromatosis, Noonan syndrome, and multiple endocrine neoplasia type 2B. 6 Gardner syndrome is related to bone tumors, especially osteomas, 7 and myofibromatosis is associated with myofibromas. 8 From the clinical standpoint, many oral and maxillofacial CSTNs have overlapping characteristics, which poses a challenge with regards to establishing the correct clinical diagnosis. These CSTNs usually appear as nodular or tumoral, painless, slow-growing, pink lesions

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