Discrepant target detection and action monitoring in obsessive–compulsive disorder

Johannes, Sönke; Wieringa, Bernardina M.; Nager, Wido; Rada, D.; Dengler, Reinhard; Emrich, H. M.; Münte, Thomas F.; Dietrich, Detlef E.

doi:10.1016/s0925-4927(01)00117-2

Cited by 163 publications

(148 citation statements)

References 48 publications

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“…We expected to find no difference in ERN latency, since it seemed to be invariant with respect to the erroneous response and largely independent of experimental manipulation (Falkenstein et al, 2000;Scheffers and Coles, 2000). Recently, however, more studies showed a modulation of ERN latency depending on the experimental manipulations (e.g., Fiehler et al, 2005;Johannes et al, 2001;Krigolson and Holroyd, 2007). It is possible that the latency of the ERN reflects prolonged error-monitoring mechanisms (Johannes et al, 2001).…”

Section: Discussionmentioning

confidence: 89%

“…Recently, however, more studies showed a modulation of ERN latency depending on the experimental manipulations (e.g., Fiehler et al, 2005;Johannes et al, 2001;Krigolson and Holroyd, 2007). It is possible that the latency of the ERN reflects prolonged error-monitoring mechanisms (Johannes et al, 2001). In the high-motivation condition, errors had more severe consequences for participants than in the low-motivation condition.…”

Section: Discussionmentioning

confidence: 99%

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Motivation and semantic context affect brain error-monitoring activity: An event-related brain potentials study

2008

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During speech production, we continuously monitor what we say. In situations in which speech errors potentially have more severe consequences, e.g. during a public presentation, our verbal selfmonitoring system may pay special attention to prevent errors than in situations in which speech errors are more acceptable, such as a casual conversation. In an event-related potential study, we investigated whether or not motivation affected participants' performance using a picture naming task in a semantic blocking paradigm. Semantic context of to-be-named pictures was manipulated; blocks were semantically related (e.g., cat, dog, horse, etc.) or semantically unrelated (e.g., cat, table, flute, etc.). Motivation was manipulated independently by monetary reward. The motivation manipulation did not affect error rate during picture naming. However, the highmotivation condition yielded increased amplitude and latency values of the error-related negativity (ERN) compared to the low-motivation condition, presumably indicating higher monitoring activity. Furthermore, participants showed semantic interference effects in reaction times and error rates. The ERN amplitude was also larger during semantically related than unrelated blocks, presumably indicating that semantic relatedness induces more conflict between possible verbal responses.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Motivation and semantic context affect brain error-monitoring activity: An event-related brain potentials study

2008

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“…For instance, a number of studies have reported enhanced ERNs in affectively distressed subjects (Gehring et al, 2000;Hajcak & Simons, 2002;Hajcak et al, 2003;Hajcak, McDonald, et al, 2004, Johannes, Wieringa, Nager, Rada, et al, 2001Luu, Collins et al, 2000). Based on these data, Luu and Tucker (in press) suggest that the ERN indexes the affective distress associated with making an error.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, a number of studies have reported enhanced ERNs in affectively distressed subjects such as patients with obsessive-compulsive disorder (OCD; Gehring, Himle, & Nisenson, 2000; Johannes, Wieringa, Nager, Rada, et al, 2001), subjects who score high in OC symptoms (Hajcak & Simons, 2002), worried subjects (Hajcak, McDonald, & Simons, 2003), and subjects who report high negative affective experience (Hajcak, McDonald, & Simons, 2004;Luu, Collins, & Tucker, 2000). Additionally, Johannes, Wieringa, Nager, Dengler, and Munte (2001) found that administration of an anxiolytic drug (Oxazepam) reduced the amplitude of the ERN, despite having no effect on performance measures.…”

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confidence: 99%

On the ERN and the significance of errors

et al. 2005

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The error-related negativity (ERN) is an event-related brain potential observed when subjects commit errors. To examine whether the ERN is sensitive to the value of errors, the motivational significance of errors was manipulated in two experiments. In Experiment 1, low and high monetary value errors were compared to evaluate the effect of trial value on the ERN. In Experiment 2, subjects performed a flanker task both while their performance was being evaluated and during a control condition. Consistent with the notion that the error-detection system is sensitive to the significance of errors, the ERN was significantly larger on high-value trials in Experiment 1 and during evaluation in Experiment 2. There were no corresponding effects on the correct response negativity, and no behavioral differences between conditions were evident in either experiment. These results are discussed in terms of the functional role of the ERN in response monitoring.Descriptors: Motivation, Event-related potentials (ERPs), Error-related negativity (ERN), Ne, Value, Affect Effective action monitoring involves appropriate performance adjustments in terms of task demands, and a crucial component of this process is the ability to detect errors and adjust performance accordingly (Falkenstein, Hoormann, Christ, & Hohnsbein, 2000). Studies that measure response-locked eventrelated brain potentials (ERPs) have described fronto-centrally maximal negative components that appear relevant to response monitoring. Perhaps most notably, when subjects make a mistake, the response-locked ERP at fronto-central recording sites is characterized by a negative deflection known as the error-related negativity (ERN or Ne) that peaks approximately 50 ms postresponse (Falkenstein et al., 2000;Falkenstein, Hohnsbein, Hoormann, & Blanke, 1991;Gehring, Coles, Meyer, & Donchin, 1990; Gerhing, Goss, Coles, Meyer, & Donchin, 1993;Holroyd & Coles, 2002;Nieuwenhuis, Ridderinkhof, Blom, Band, & Kok, 2001).Because the ERN has been observed across different stimulus and response modalities, it is thought to reflect the activity of a generic response monitoring system (Bernstein, Scheffers, & Coles, 1995;Dehaene, Posner, & Tucker, 1994;Falkenstein et al., 1991Falkenstein et al., , 2000Holroyd, Dien, & Coles, 1998;Luu, Flaisch, & Tucker, 2000;Miltner, Braun, & Coles, 1997;Van 't Ent & Apkarian, 1999). Studies utilizing source localization suggest that the ERN is generated in the medial frontal cortex, most likely the anterior cingulate cortex (ACC; Dehaene et al., 1994;Holroyd et al., 1998;Miltner et al., 1997).In addition to the ERN, a small negative deflection has also been observed in the response-locked ERP on correct trials. This correct response negativity (CRN) appears to have morphological and topographical properties similar to the ERN (Vidal, Burle, Bonnet, Grapperon, & Hasbroucq, 2003;Vidal, Hasbroucq, Grapperon, & Bonnet, 2000). Although the functional significance of the CRN is unknown, the similarities between the ERN and CRN suggest that both compon...

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“…Overactive error monitoring processes and increased ERN/Ne (but not Pe) amplitudes have, for example, been observed systematically in individuals with high levels of anxiety and/or negative affect (Aarts & Pourtois, 2010;Endrass, Klawohn, Schuster, & Kathmann, 2008;Gehring, Himle, & Nisenson, 2000;Hajcak, McDonald, & Simons, 2003aHajcak & Simons, 2002;Johannes et al, 2001;Moser, Moran, & Jendrusina, 2012;Nieuwenhuis, Nielen, Mol, Hajcak, & Veltman, 2005). In line with these studies, Luu, Collins and Tucker (2000) initially suggested that the ERN/Ne component may actually reflect the enhanced emotional significance of an error.…”

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confidence: 82%

Erroneous and correct actions have a different affective valence: Evidence from ERPs.

Aarts¹,

Houwer²,

Pourtois³

2013

Emotion

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The accuracy of actions is swiftly determined through specific monitoring brain systems. Event-related potential (ERP) studies have shown that error commission is associated with the generation of the error-related negativity (ERN/Ne), while correct actions with the correct-related negativity (CRN). Although the exact functional meaning of the ERN/Ne (and CRN) component remains debated, some authors have suggested that it reflects the processing of the emotional significance of actions. However, no study to date has directly linked amplitude changes at the level of the ERN/Ne-CRN to the affective processing of actions. In order to decode the emotional valence of actions performed during a Go/noGo task, we used an evaluative priming method in this study. After each action following the Go/noGo stimulus, participants had to categorize an evaluative word as either positive or negative. Behavioral results showed that response errors (i.e., False Alarms -FAs) performed during the Go/noGo task led to a faster categorization of negative than positive words.Remarkably, this evaluative priming effect was related to the magnitude of the ERN/Ne component generated during the Go/noGo task. Moreover, ERP results showed that the processing of evaluative words following FAs was influenced early on after word onset (early posterior negativity-EPN effect), while it was influenced later following correct as well as incorrect actions (late positive potential-LPP effect). Altogether, these ERP results suggest that the action-related ERN-CRN component encodes the perceived emotional significance of actions, such that early stages of evaluative word processing following these actions are influenced by this automatic process.3

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Discrepant target detection and action monitoring in obsessive–compulsive disorder

Cited by 163 publications

References 48 publications

Motivation and semantic context affect brain error-monitoring activity: An event-related brain potentials study

Motivation and semantic context affect brain error-monitoring activity: An event-related brain potentials study

On the ERN and the significance of errors

Erroneous and correct actions have a different affective valence: Evidence from ERPs.

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