Discovery of new anticancer agents from higher plants

Kinghorn, A. D.

doi:10.2741/s257

Cited by 64 publications

(5 citation statements)

References 105 publications

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Section: Introductionmentioning

confidence: 99%

“…The development of anticancer drugs derived from medicinal herbs has played an important role in the effective treatment of cancer patients (13,14). In addition, medicinal herbs have long been used as anticancer materials and folk remedies by extracting active ingredients and developing them into drugs (13,14). In order to overcome the occurrence of anticancer drug resistance, various biological resources, including medicinal herbs, have been assessed for the development of anticancer drugs, and their importance is increasing (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Effect of Salvia plebeia and Its Active Compound by Improving T-Cell Activity via Blockade of PD-1/PD-L1 Interaction in Humanized PD-1 Mouse Model

Choi

Kim

et al. 2020

Front. Immunol.

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Immune checkpoint inhibitors, increasingly used to treat malignant tumors, are revolutionizing cancer treatment by improving the patient survival expectations. Despite the high antitumor efficacy of antibody therapeutics that bind to PD-1/PD-L1, study on small molecule-based PD-1/PD-L1 inhibitors is required to overcome the side effects of antibody therapeutics caused by their size and affinity. Herein, we investigated antitumor potential of Salvia plebeia R. Br. extract (SPE), which has been used as a traditional oriental medicine and food in many countries, and its components by the blockade of PD-1/PD-L1 interaction. SPE and its component cosmosiin effectively blocked the molecular interaction between PD-1 and PD-L1. SPE also inhibited tumor growth by increasing CD8+ T-cells in the tumor through the activation of tumor-specific T-cells in a humanized PD-1 mouse model bearing hPD-L1 knock-in MC38 colon adenocarcinoma tumor. This finding presents a preclinical strategy to develop small molecule-based anticancer drugs targeting the PD-1/PD-L1 immune checkpoint pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Effect of Salvia plebeia and Its Active Compound by Improving T-Cell Activity via Blockade of PD-1/PD-L1 Interaction in Humanized PD-1 Mouse Model

Choi

Kim

et al. 2020

Front. Immunol.

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“…This highlights that medicinal plants remain a source of new drugs [69], e.g., vinblastine or vincristine obtained from the Vinca sp., paclitaxel from the Taxus sp., camptothecin from the Camptotheca sp., or podophyllotoxin from Podophyllum sp. [48,61,70,71]. These compounds often exert their anticancer activity by inhibiting the proliferation of cancer cells and inducing cell death [67].…”

Section: Cancer and Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer Institute. As the global medical cost of cancer in 2020 will exceed about $150 billion, new approaches and novel alternative chemoprevention molecules are needed. Research indicates that the plants of the Lamiaceae family may offer such potential. The present study reviews selected species from the Lamiaceae and their active compounds that may have the potential to inhibit the growth of lung, breast, prostate, and colon cancer cells; it examines the effects of whole extracts, individual compounds, and essential oils, and it discusses their underlying molecular mechanisms of action. The studied members of the Lamiaceae are sources of crucial phytochemicals that may be important modulators of cancer-related molecular targets and can be used as effective factors to support anti-tumor treatment.

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“…Out of 136 verified anticancer drugs since 1981 till 2014, 113 are natural products or their derivatives (Newman & Cragg, 2016). The presence of intricate carbon skeletons and functional groups of natural compounds enhance their bioactivity spectrum with unique modes of action at several targets (Amaral et al, 2019;Pan et al, 2012;Tesfaye & Ravichadran, 2018). The phosphatidylinositol-3-kinase/Akt signaling pathway is one of the prime drug targets in cancer therapy (Ihle & Powis, 2009) in context of its reported overexpression in various forms of cancers especially in colorectal cancers (Narayanankutty, 2019).…”

Section: Introductionmentioning

confidence: 99%

The modulation of PI3K/Akt pathway by 3β hydroxylup‐12‐en‐28‐oic acid isolated from Thymus linearis induces cell death in HCT‐116 cells

et al. 2021

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The presence of intricate carbon skeletons in natural compounds enhances their bioactivity spectrum with unique modes of action at several targets in various dreadful diseases like cancer. The present study was designed to purify the molecules from Thymus linearis and elucidate their antiproliferative activity. The compounds were isolated from the active methanolic extract of Thymus linearis through column chromatography and characterized by various spectroscopic techniques. Antiproliferative activity of isolated compounds was evaluated using MTT assay on cancer and normal cell lines. Mechanism of cell death was elucidated using flow cytometric, microscopic, and Western blot analysis. Four compounds, Sitosterol, Chrysin, 3β-hydroxylup-12-en-28-oic acid (3BH), and β-Sitosterol glycoside, were isolated. Among these, 3BH was most potent antiproliferative agent across all cell lines under study, HCT-116 being the most affected one. 3BH was demonstrated to downregulate PI3Ksubunits (p110α and p85α), downstream pAktSer 473 and prompted G 1 phase cell cycle arrest. The cell cycle CDK inhibitor p27 and p21 were upregulated with simultaneous downregulation of cyclin D1 and cyclin E in HCT-116 cells. This was accompanied by apoptosis, as depicted by decrease in Bcl-2/Bax ratio, with increase in active caspases-3 and caspase-9, cleavage of PARP-1, the generation of reactive oxygen species (ROS), and the loss of mitochondrial membrane potential. The findings established that 3BH induced cell death in HCT-116 cells by modulating PI3K/Akt signaling axis, impeding cell cycle, and instigating apoptosis.

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Discovery of new anticancer agents from higher plants

Cited by 64 publications

References 105 publications

Anticancer Effect of Salvia plebeia and Its Active Compound by Improving T-Cell Activity via Blockade of PD-1/PD-L1 Interaction in Humanized PD-1 Mouse Model

Anticancer Effect of Salvia plebeia and Its Active Compound by Improving T-Cell Activity via Blockade of PD-1/PD-L1 Interaction in Humanized PD-1 Mouse Model

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

The modulation of PI3K/Akt pathway by 3β hydroxylup‐12‐en‐28‐oic acid isolated from Thymus linearis induces cell death in HCT‐116 cells

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